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7 documents found
1: Title: Dynamic gene expression response to altered gravity in human T cells.
Authors: Thiel, Cora S, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 5204, 2017 .
Snippet: We identified three gravity-regulated genes which could be cross-validated in both completely independent experiment missions: ATP6V1A/D, a vacuolar H + -ATPase (V-ATPase) responsible for acidification during bone resorption, IGHD3-3/IGHD3-10, diversity genes of the immunoglobulin heavy-chain locus participating in V(D)J recombination, and LINC00837, a long intergenic non-protein coding RNA.
Affiliation: Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. cora.thiel@uzh.ch. Department of Machine Design, Engineering Design and Product Development, Institute of Mechanical Engineering, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany. cora.thiel@uzh.ch. Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. Department of Machine Design, Engineering Design and Product Development, Institute of Mechanical Engineering, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany. Core Facility Genomic, Medical Faculty of Muenster, University of Muenster, Albert-Schweitzer-Campus 1, D3, Domagstrasse 3, 48149, Muenster, Germany. KEK GmbH, Kemberger Str. 5, 06905, Bad Schmiedeberg, Germany. Ernst-Abbe-Hochschule Jena, Carl-Zeiss-Promenade 2, 07745, Jena, Germany. Airbus DS GmbH, Airbus-Allee 1, 28199, Bremen, Germany. Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. oliver.ullrich@uzh.ch. Department of Machine Design, Engineering Design and Product Development, Institute of Mechanical Engineering, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany. oliver.ullrich@uzh.ch. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. oliver.ullrich@uzh.ch. Institute of Space Life Sciences, School of Life Sciences, Beijing Institute of Technology, Beijing, 100081, China. oliver.ullrich@uzh.ch. .
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2: Title: IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope.
Authors: Que, Xuchu, et.al. .
Journal: PloS one, Vol. 8 (6): e65203, 2013 .
Snippet: We found that antibodies encoded by one particular IGHV1-69 subset, designated CLL69C, with the HCDR3 encoded by the IGHD3-3 gene in reading frame 2 and IGHJ6, specifically bound to oxidation-specific epitopes (OSE), which are products of enhanced lipid peroxidation and a major target of innate natural antibodies.
Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, USA. xque@ucsd.edu .
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3: Title: Immune thrombocytopenia in patients with chronic lymphocytic leukemia is associated with stereotyped B-cell receptors.
Authors: Visco, Carlo, et.al. .
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res), Vol. 18 (7): 1870-8, 2012 .
Snippet: The more frequent stereotyped HCDR3 subsets were #1 (IGHV1-5-7/IGHD6-19/IGHJ4; 16 of 16 unmutated) and #7 (IGHV1-69 or IGHV3-30/IGHD3-3/IGHJ6; 13 of 13 unmutated), both being significantly more represented among patients developing ITP (P = 0.003 and P = 0.001, respectively).
Affiliation: Department of Hematology, Ospedale San Bortolo, Vicenza, Milano, Italy. .
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4: Title: Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy.
Authors: Tsakou, Eugenia, et.al. .
Journal: Molecular medicine (Cambridge, Mass.) (Mol Med), Vol. 18, 2012 .
Snippet: Among CLL carrying productively rearranged D-J, comparison of the IGHD gene repertoire in productive V-D-J versus D-J revealed the following: (a) overuse of IGHD reading frames encoding hydrophilic peptides among V-D-J and (b) selection of the IGHD3-3 and IGHD6-19 genes in V-D-J junctions.
Affiliation: Hematology Department, Democritus University of Thrace, Alexandroupolis, Greece. .
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5: Title: IGHD3-3 fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia.
Authors: Bomben, Riccardo, et.al. .
Journal: British journal of haematology (Br J Haematol), Vol. 149 (2): 299-302, 2010 .
No Abstract available.
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6: Title: Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients.
Authors: Tschumper, Renee C, et.al. .
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 118 (1): 306-15, 2008 .
Snippet: Irrespective of IGHV usage, UM patients whose B-CLL cells expressed the IGHD3-3 gene had a significantly shorter TTT than other UM B-CLL patients, and specifically, use of the IGHD3-3 gene in reading frame 2 (RF2) predicted shorter TTT.
Affiliation: Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. .
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7: Title: Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.
Journal: Blood, Vol. 111 (6): 3137-44, 2008 .
Snippet: Similarly, 83% (5/6) of samples with motif CLL69D encoded by IGHD2-2/IGHJ6 expressed IGKV3-11, 100% (25/25) with motif CLL69A encoded by IGHD3-16/IGHJ3 used IGKV3-20, and 77% (10/13) with motif CLL69C encoded by IGHD3-3/IGHJ6 expressed IGLV3-9.
Affiliation: Chronic Lymphocytic Leukemia Research Consortiuim, La Jolla, CA, USA. .
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