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13 documents found
1: Title: An Expanded Role for HLA Genes: HLA-B Encodes a microRNA that Regulates IgA and Other Immune Response Transcripts.
Authors: Chitnis, Nilesh, et.al. .
Journal: Frontiers in immunology (Front Immunol), Vol. 8, 2017 .
Snippet: We identified a conserved miR-6891-5p target site on the 3'UTR of both immunoglobulin heavy chain alpha 1 and 2 (IGHA1 and IGHA2) transcripts and demonstrated that this miRNA modulates the expression of IGHA1 and IGHA2.
Affiliation: Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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2: Title: Nodal metastasis signatures in breast cancer.
Authors: Park, Kyeongmee, et.al. .
Journal: Pathology, research and practice (Pathol Res Pract), Vol. 213 (6): 680-687, 2017 .
Snippet: Cox proportional hazards regression analyses indicated that event factors (recurrence or metastasis) were significantly more frequent in cases with CCDN1, c-myc gene amplification, IgHA2 low expression.
Affiliation: Dept of Pathology, Inje University Sanggye Paik Hospital, Republic of Korea. Dept of Pathology, Yonsei University College of Medicine, Republic of Korea; Brain Korea 21 Project for Medical Science, Republic of Korea. Dept of Pathology, Yonsei University College of Medicine, Republic of Korea; Biomedical Institute, Yonsei University College of Medicine, Republic of Korea. Dept of Pathology, Yonsei University College of Medicine, Republic of Korea. Dept of Pathology, Gacheon Medical University, Republic of Korea. Biostatistics Collaboration Unit, Yonsei University College of Medicine, Republic of Korea. Dept of Pathology, Yonsei University College of Medicine, Republic of Korea; Brain Korea 21 Project for Medical Science, Republic of Korea; Biomedical Institute, Yonsei University College of Medicine, Republic of Korea. Electronic address: cho1988@yuhs.ac. .
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3: Title: Novel exons and splice variants in the human antibody heavy chain identified by single cell and single molecule sequencing.
Authors: Vollmers, Christopher, et.al. .
Journal: PloS one, Vol. 10 (1): e0117050, 2015 .
Snippet: We performed both single B cell RNAseq and long read single molecule sequencing of antibody heavy chain transcripts and were able to identify novel exons for IGHA1 and IGHA2 as well as novel isoforms for IGHM antibody heavy chain.
Affiliation: Dept. of Bioengineering, Stanford University, Stanford, California, United States of America. Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America. Dept. of Bioengineering, Stanford University, Stanford, California, United States of America; Dept. of Applied Physics, Stanford University, Stanford, California, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America. .
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4: Title: Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels.
Authors: Jackson, Katherine J L, et.al. .
Journal: Immunology and cell biology (Immunol Cell Biol), Vol. 92 (8): 729-33, 2014 .
Snippet: Antigen selection was also significantly higher in IgA2 than in IgA1 sequences, raising the possibility of a preferential switch pathway from IGHG2 to IGHA2.
Affiliation: School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia. .
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5: Title: In situ identification and localization of IGHA2 in the breast tumor microenvironment by mass spectrometry.
Authors: Kang, Suki, et.al. .
Journal: Journal of proteome research (J Proteome Res), Vol. 11 (9): 4567-74, 2012 .
Snippet: Using direct-tissue MALDI tandem mass spectrometry (MS/MS), we identified immunoglobulin heavy constant alpha 2 (IGHA2) as a new, zone-specific protein in the breast TME.
Affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. .
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6: Title: Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism.
Authors: Lefranc, Marie-Paule, et.al. .
Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol), Vol. 882, 2012 .
Snippet: Gm-Am allotypes are inherited in fixed combinations, or Gm-Am haplotypes, owing to the linkage of the human IGHC genes (IGHG3, IGHG1, IGHA1, IGHG2, IGHG4, IGHE, and IGHA2 from 5' to 3' in the IGH locus on chromosome 14).
Affiliation: IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142, Montpellier, France. Marie-Paule.Lefranc@igh.cnrs.fr .
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7: Title: Characterization of the horse (Equus caballus) IGHA gene.
Authors: Wagner, Bettina, et.al. .
Journal: Immunogenetics, Vol. 55 (8): 552-60, 2003 .
Snippet: The coding nucleotide sequence of the secreted form of the equine IGHA gene shares around 72% identity with the human IGHA1 and IGHA2 genes, as well as the bovine, ovine, porcine and canine IGHA genes, without distinct preference for any of these species.
Affiliation: James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA. bw73@cornell.edu .
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8: Title: Tandem repeats 3' of the IGHA genes in the human immunoglobulin heavy chain gene cluster.
Authors: Kang, H K, et.al. .
Journal: Genomics, Vol. 35 (1): 189-95, 1996 .
Snippet: All of the constant region gene cluster has been cloned except for sequences between the IGHD and IGHG3 genes, between the IGHA1 and IGHG2 genes, and the 3' region downstream of the IGHA2 gene.
Affiliation: Research Institute, The Hospital for Sick Children, Toronto. .
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9: Title: New allele variants of the immunoglobulin switch (Salpha) regions.
Authors: Keyeux, G, et.al. .
Journal: Human genetics (Hum Genet), Vol. 97 (5): 695-6, 1996 .
Snippet: In this report we define ten Salpha1 IGHA1 (*S5-*S14) and nine Salpha2 IGHA2 (*S10-*S18) newly found alleles of the human immunoglobulin switch alpha 1 and switch alpha 2 regions, respectively, in Colombian Indian, Black and Mestizo populations, and a complete list of the SacI and PvuII alleles so far identified as given.
Affiliation: Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogatá, Colombia. .
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10: Title: Sequence of the CH1 and hinge-CH2 exons of the human immunoglobulin IGHA2 A2m(2) allele: comparison with the nonallelic and allelic IGHA genes.
Authors: Bensmana, M, et.al. .
Journal: Cytogenetics and cell genetics (Cytogenet Cell Genet), Vol. 56 (2): 128, 1991 .
No Abstract available.
Affiliation: Laboratoire d'Immunogénétique Moléculaire, URA CNRS 1191, Université Montpellier II, France. .
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11: Title: Genetic variation at the immunoglobulin allotype loci in Creoles of Trinidad.
Authors: McGowan, V M, et.al. .
Journal: American journal of physical anthropology (Am J Phys Anthropol), Vol. 81 (4): 555-62, 1990 .
Snippet: The sera of a sample of 204 Creoles from Trinidad were tested for the presence of polymorphic gene complexes occurring on immunoglobulin light- and heavy-chain molecules including the allotypic markers IGKC 1, IGHA2 1 and 2, IGHG1 A, X, F, and Z, and IGHG3 G, G5, B0, B1, B3, B4, B5, C3, C5, S, and T. Nine IGHG (GM) haplotypes occur in polymorphic frequencies (greater than .01) in this population, including known African, Asian, Caucasian, and Amerindian marker haplotypes.
Affiliation: Department of Anthropology, University of Toronto, Ontario, Canada. .
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12: Title: Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains.
Authors: Bensmana, M, et.al. .
Journal: Immunogenetics, Vol. 32 (5): 321-30, 1990 .
Snippet: We have determined the nucleotide sequences of the human IGHG3, IGHA1, and IGHA2 membrane exons isolated from genomic DNA libraries.
Affiliation: Laboratoire d'Immunogénétique Moléculaire, URA CNRS 1191, Université Montpellier II, France. .
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13: Title: Frequencies of the human immunoglobulin IGHA2*M1 and IGHA2*M2 alleles corresponding to the A2m(1) and A2m(2) allotypes in the French, Lebanese, Tunisian and black African populations.
Authors: Soua, Z, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 17 (9): 3625, 1989 .
No Abstract available.
Affiliation: Laboratoire d'Immunogénétique Moléculaire, URA CNRS 199, Université des Sciences et Techniques du Languedoc, Montpellier, France. .
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