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10 documents found
1: Title: Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours.
Authors: Arendt, Maja L, .
Journal: PLoS genetics (Plos Genet), Vol. 11 (11): e1005647, 2015 .
Snippet: In addition, disease associated haplotypes harbouring the hyaluronidase genes HYAL1, HYAL2 and HYAL3 on cfa20 and HYAL4, SPAM1 and HYALP1 on cfa14 were identified as separate risk factors in European and US golden retrievers, respectively, suggesting that turnover of hyaluronan plays an important role in the development of CMCT.
Affiliation: Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America. Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, United States of America. Animal Health Trust, Newmarket, United Kingdom. Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands. Department of Veterinary Clinical Sciences Ohio State University, Columbus, Ohio, United States of America. Veterinary Specialist Center De Wagenrenk, Wageningen, The Netherlands. .
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2: Title: Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors.
Authors: Rizzardi, Anthony E, .
Journal: Cancer, Vol. 120 (12): 1800-9, 2014 .
Snippet: Hyaluronan (HA) is a high molecular weight polyanionic carbohydrate produced by synthases (HAS1 through HAS3) and fragmented by oxidative/nitrosative stress and hyaluronidases (HYAL1 through HYAL4, SPAM1) common in PCa microenvironments.
Affiliation: Department of Pathology, University of Washington, Seattle, Washington; Department of Laboratory Medicine and Pathology and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. .
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3: Title: Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.
Authors: Li, Yunbo, .
Journal: PloS one, Vol. 8 (2): e57168, 2013 .
Snippet: Subsequently, we confirmed well-characterized oncogenes among tumor-related loci (such as EGFR and KIT) and detected novel genes that gained chromosome sequences (such as AASS, HYAL4, NDUFA5 and SPAM1) in both LGG and HGG.
Affiliation: First Hospital of Jilin University, Changchun, PR China. .
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4: Title: Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).
Authors: Kaneiwa, Tomoyuki, .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 287 (50): 42119-28, 2012 .
Snippet: Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-β-N-acetylgalactosaminidase.
Affiliation: Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo 001-0021, Japan. .
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5: Title: Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.
Authors: Atmuri, Vasantha, .
Journal: Matrix biology : journal of the International Society for Matrix Biology (Matrix Biol), Vol. 27 (8): 653-60, 2008 .
Snippet: In humans, six paralogous genes encoding hyaluronidase-like sequences have been identified on human chromosomes 3p21.3 (HYAL2-HYAL1-HYAL3) and 7q31.3 (SPAM1-HYAL4-HYALP1). Mutations in one of these genes, HYAL1, were reported in a patient with mucopolysaccharidosis (MPS) IX.
Affiliation: Department of Biochemistry and Medical Genetics, The University of Manitoba, Winnipeg, MB, Canada. .
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6: Title: Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.
Authors: Kim, Ekyune, .
Journal: Proceedings of the National Academy of Sciences of the United States of America (P Natl Acad Sci Usa), Vol. 102 (50): 18028-33, 2005 .
Snippet: Hyal5 was exclusively expressed in the testis and formed a 160-kbp gene cluster together with Hyalp1, Hyal4, and Ph-20 on mouse chromosome 6.
Affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan. .
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7: Title: Hyaluronidases and CD44 undergo differential modulation during chondrogenesis.
Authors: Nicoll, Steven B, .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 292 (4): 819-25, 2002 .
Snippet: No expression of HYAL4 and PH-20, the sperm-associated hyaluronidase, was detected.
Affiliation: Joint Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, California 94143-0775, USA. .
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8: Title: The six hyaluronidase-like genes in the human and mouse genomes.
Authors: Csoka, A B, .
Journal: Matrix biology : journal of the International Society for Matrix Biology (Matrix Biol), Vol. 20 (8): 499-508, 2001 .
Snippet: and another two genes (HYAL4 and PH-20/SPAM1) and one expressed pseudogene (HYALP1) are similarly clustered on chromosome 7q31.3.
Affiliation: Department of Pathology, School of Medicine, University of California-San Francisco, LR-101, 4 Koret Way, San Francisco, CA 94143-0506, USA. .
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9: Title: Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species.
Authors: Fiszer-Szafarz, B, .
Journal: Journal of biochemical and biophysical methods (J Biochem Bioph Meth), Vol. 45 (2): 103-16, 2000 .
Snippet: A potential N-glycosylation site (site 1) with similar tripeptide patterns was observed at the same position in human plasma (HYAL1), human lysosomes (HYAL2) and in two newly reported hyaluronidases (HYAL4 and HYALP1).
Affiliation: Institut Curie-Biologie, Centre Universitaire, 91405, Cedex, Orsay, France. .
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10: Title: Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31.
Authors: Csóka, A B, .
Journal: Genomics, Vol. 60 (3): 356-61, 1999 .
Snippet: HYAL1, HYAL2, and HYALP1 are widely expressed, but HYAL3 is differentially expressed in bone marrow and testis, while HYAL4 is differentially expressed in placenta and skeletal muscle.
Affiliation: Department of Gerontology, University Medical School of Debrecen, Debrecen, H-4012, Hungary. .
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