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45 documents found
1: Title: Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3.
Authors: Clark, Alice R, et.al. .
Journal: Journal of molecular biology (J Mol Biol), 2018 .
Snippet: HspB2 and HspB3 are vertebrate sHsps that are found co-assembled in neuromuscular cells, and variants thereof are associated with disease.
Affiliation: Department of Biological Sciences, Crystallography, Institute of Structural & Molecular Biology, Birkbeck College, Malet Street, London, WC1E 7HX, UK. Radboud University Nijmegen, Inst. Molecules & Materials, Dept Biomol Chem, NL-6500 Nijmegen, Netherlands. Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford, South Parks Rd, Oxford, OX1 3QZ, UK. Research School of Chemistry, Australian National University, Acton, ACT, 2601, Australia. Department of Biological Sciences, Crystallography, Institute of Structural & Molecular Biology, Birkbeck College, Malet Street, London, WC1E 7HX, UK. Electronic address: n.keep@mail.cryst.bbk.ac.uk. .
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2: Title: Small Heat Shock Protein B3 (HSPB3) Mutation in an Axonal Charcot-Marie-Tooth Disease Family.
Authors: Nam, Da Eun, et.al. .
Journal: Journal of the peripheral nervous system : JPNS (J Peripher Nerv Syst), 2018 .
Snippet: HSPB3 gene encodes a small heat-shock protein 27-like protein which has a high sequence homology with HSPB1.
Affiliation: Department of Biological Sciences, Kongju National University, 56 Gonjudaehak-ro, Gongju, 32588, Korea. Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. .
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3: Title: Direct biological effects of fractional ultrapulsed CO2 laser irradiation on keratinocytes and fibroblasts in human organotypic full-thickness 3D skin models.
Authors: Schmitt, L, et.al. .
Journal: Lasers in medical science (Lasers Med Sci), 2017 .
Snippet: On day 5 after laser injury with a laser fluence of 100 mJ/cm2, gene array analysis identified an upregulation of genes associated with tissue remodeling and wound healing (e.g., COL12A1 and FGF7), genes that are involved in the immune response (e.g., CXCL12 and CCL8) as well as members of the heat shock protein family (e.g., HSPB3).
Affiliation: Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. lschmitt@ukaachen.de. Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. Department of Oral and Maxillofacial Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany. Interdisciplinary Center for Laser Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany. .
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4: Title: Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
Authors: Morelli, Federica F, et.al. .
Journal: Cell reports (Cell Rep), Vol. 20 (9): 2100-2115, 2017 .
Snippet: Furthermore, these findings support the idea that aberrant HSPB2 phase separation, due to HSPB3 loss-of-function mutations, contributes to myopathy.
Affiliation: Department of Biomedical, Metabolic and Neuronal Sciences, University of Modena and Reggio Emilia, and Center for Neuroscience and Neurotechnology, 41125 Modena, Italy. Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands. Department of Surgery, Medicine, Dentistry and Morphology, University of Modena and Reggio Emilia, 41125 Modena, Italy. Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy. Department of Cell Biology, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands. Meinig School of Biomedical Engineering, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853-7202, USA. Department of Neurosciences, University of Padua, 35122 Padua, Italy. IRCCS S. Camillo Hospital, 30126 Lido Venice, Italy. Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Department of Biomedical, Metabolic and Neuronal Sciences, University of Modena and Reggio Emilia, and Center for Neuroscience and Neurotechnology, 41125 Modena, Italy. Electronic address: serena.carra@unimore.it. .
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5: Title: Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats.
Journal: Cell stress & chaperones (Cell Stress Chaperones), Vol. 22 (4): 653-663, 2017 .
Snippet: On the mRNA level out of the 11 HspBs investigated, HspB1/Hsp25, HspB3, HspB4/αA-crystallin, HspB5/αB-crystallin, HspB7/cvHsp, and HspB8/Hsp22 were significantly upregulated in the peri-infarct region of the cerebral cortex of infarcted hemispheres.
Affiliation: Institute of Anatomy and Cell Biology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany. Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany. Institute of Anatomy and Cell Biology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany. nikola.golenhofen@uni-ulm.de. .
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6: Title: A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.
Authors: Cottee, Matthew A, et.al. .
Journal: Biology open (Unknown Journal), Vol. 6 (3): 381-389, 2017 .
Snippet: Here, we show that the isolated HsCCD and HsPB3 domains form a mixture of homo-multimers in vitro, but these readily dissociate when mixed to form the previously described 1:1 HsCCD:HsPB3 complex.
Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK jordan.raff@path.ox.ac.uk susan.lea@path.ox.ac.uk. .
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7: Title: An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.
Authors: Morelli, Federica F, et.al. .
Journal: Cell stress & chaperones (Cell Stress Chaperones), Vol. 22 (4): 531-540, 2017 .
Snippet: HSPBs form hetero-oligomers and homo-oligomers by interacting together and complexes containing, e.g., HSPB2/HSPB3 or HSPB1/HSPB5 have been documented in mammalian cells and muscles.
Affiliation: Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy. Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy. serena.carra@unimore.it. Department of Cell Biology, University Medical Center Groningen; University of Groningen, Groningen, The Netherlands. serena.carra@unimore.it. .
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8: Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
Authors: Echaniz-Laguna, Andoni, et.al. .
Journal: Human mutation (Hum Mutat), Vol. 38 (5): 556-568, 2017 .
Snippet: Patients have slowly progressive distal (100%) and proximal (13%) weakness in lower limbs (100%), mild lower limbs sensory involvement (31%), foot deformities (73%), progressive distal upper limb weakness (29%), mildly raised serum creatine kinase levels (100%), and central nervous system involvement (9%).
Affiliation: Department of Neurology, Neuromuscular Disease Centre (CERNEST), Strasbourg University Hospital, Strasbourg, France. Peripheral Neuropathy Group, VIB Department of Molecular Genetics and Institute Born Bunge, University of Antwerp, Antwerpen, Belgium. Neuromuscular Disease Centre, Lyon University Hospital, Lyon, France. Neuromuscular Disease Centre, Nantes University Hospital, Nantes, France. Neuromuscular Disease Centre, Hôpital de la Pitié-Salpétrière, APHP, Paris, France. APHP, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Paris, France. Neuromuscular Disease Centre, Nice University Hospital, Nice, France. Neuromuscular Disease Centre, Marseille University Hospital, APHM, Marseille, France. Neuromuscular Disease Centre, Montpellier University Hospital, Montpellier, France. Department of Genetics, Bordeaux University Hospital, Bordeaux, France. Biology and Pathology Department, Lyon University Hospital, Bron, France. .
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9: Title: Chaperonopathies: Spotlight on Hereditary Motor Neuropathies.
Authors: Lupo, Vincenzo, et.al. .
Journal: Frontiers in molecular biosciences (Unknown Journal), Vol. 3, 2016 .
Snippet: To date, 23 genes are thought to be responsible for dHMN, four of which encode chaperones: DNAJB2, which encodes a member of the HSP40/DNAJ co-chaperone family; and HSPB1, HSPB3, and HSPB8, encoding three members of the small heat shock protein family.
Affiliation: Molecular Basis of Human Diseases Program, Centro de Investigación Príncipe FelipeValencia, Spain; INCLIVA & IIS La Fe Rare Diseases Joint UnitsValencia, Spain. Molecular Basis of Human Diseases Program, Centro de Investigación Príncipe FelipeValencia, Spain; INCLIVA & IIS La Fe Rare Diseases Joint UnitsValencia, Spain; Centro de Investigación Biomédica en RedValencia, Spain. .
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10: Title: The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins.
Authors: Mymrikov, Evgeny V, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (2): 672-684, 2017 .
Snippet: We discovered that sHsps, which form large oligomers (HspB1/Hsp27, HspB3, HspB4/αA-crystallin, and HspB5/αB-crystallin) are promiscuous chaperones, whereas the chaperone activity of the other sHsps is more substrate-dependent.
Affiliation: From the Center for Integrated Protein Science at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany. From the Center for Integrated Protein Science at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany johannes.buchner@tum.de. .
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11: Title: HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.
Authors: La Padula, Veronica, et.al. .
Journal: Experimental neurology (Exp Neurol), Vol. 286, 2016 .
Snippet: Therefore, we studied the endogenous HSPB3 protein distribution in the spinal cords of chicken and mouse embryos and in the postnatal nervous system (central and peripheral) of chicken, mouse and human.
Affiliation: Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Albertstraße 17, 79104 Freiburg, Germany. Electronic address: veronicalapadula@gmail.com. Institute of Neuropathology, Neurozentrum, Breisacherstraße 64, 79106 Freiburg, Germany. Electronic address: ori.staszewski@uniklinik-freiburg.de. Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Albertstraße 17, 79104 Freiburg, Germany. Systems Biology of the Cellular Microenvironment Group, Institute of Molecular Medicine and Cell Research, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: h.busch@dkfz.de. Systems Biology of the Cellular Microenvironment Group, Institute of Molecular Medicine and Cell Research, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: m.boerries@dkfz-heidelberg.de. Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Albertstraße 17, 79104 Freiburg, Germany; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Albertstraße 17, 79104 Freiburg, Germany. Electronic address: eleni.roussa@anat.uni-freiburg.de. Institute of Neuropathology, Neurozentrum, Breisacherstraße 64, 79106 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Germany. Electronic address: marco.prinz@uniklinik-freiburg.de. Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Albertstraße 17, 79104 Freiburg, Germany. Electronic address: kerstin.krieglstein@uniklinik-freiburg.de. .
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12: Title: Small Heat Shock Proteins and Distal Hereditary Neuropathies.
Authors: Nefedova, V V, et.al. .
Journal: Biochemistry. Biokhimii︠a︡ (Biochemistry (mosc)), Vol. 80 (13): 1734-47, 2015 .
Snippet: Data on point mutation of HspB3 associated with axonal neuropathy are presented.
Affiliation: Lomonosov Moscow State University, Faculty of Biology, Moscow, 119991, Russia. NBGusev@mail.ru. .
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13: Title: Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.
Authors: Rusmini, Paola, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Both HSPB8 and its co-chaperone BAG3 were robustly upregulated together with other specific HSPB8 interactors (HSPB2 and HSPB3).
Affiliation: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy. Centro InterUniversitario sulle Malattie Neurodegenerative, Università degli Studi di Firenze, Genova, Roma Tor Vergata and Milano, Italy. Dulbecco Telethon Institute, Centre for Integrative Biology (CIBIO), Università degli Studi di Trento, Trento, Italy. Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA. Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova, Italy. Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova. Laboratory of Experimental Neurobiology, C. Mondino National Neurological Institute, Pavia, Italy. .
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14: Title: Mitochondrial dynamics and inherited peripheral nerve diseases.
Authors: Pareyson, Davide, et.al. .
Journal: Neuroscience letters (Neurosci Lett), Vol. 596, 2015 .
Snippet: Microtubules, neurofilaments, and chaperones such as heat shock proteins (HSPs) also have a fundamental role in mitochondrial transport and mutations in some of related encoding genes cause peripheral neuropathy (TUBB3, NEFL, HSPB1, HSPB8, HSPB3, DNAJB2).
Affiliation: Clinic of Central and Peripheral Degenerative Neuropathies Unit, Department of Clinical Neurosciences - IRCCS Foundation, "C. Besta" Neurological Institute, Milan, Italy. Electronic address: davide.pareyson@istituto-besta.it. Clinic of Central and Peripheral Degenerative Neuropathies Unit, Department of Clinical Neurosciences - IRCCS Foundation, "C. Besta" Neurological Institute, Milan, Italy. .
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15: Title: [Coexpression of genes located in the 111.35-116.16 Mb of chromosome 13 in mice with different predisposition to catalepsy].
Authors: Siniakova, N A, et.al. .
Journal: Molekuliarnaia biologiia (Mol Biol (mosk)), Vol. 48 (5): 733-41, 2014 Sep-Oct .
Snippet: Gene expression of Hspb3 n Mocs2, which codes heat shock protein and, molybdenum cofactor synthesis, respectively, in substantia nigra is reduced in cataleptic CBA and D13 mice compared to catalepsy-resistant AKR mice.
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16: Title: Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.
Authors: Yang, Zongguo, et.al. .
Journal: International journal of medical sciences (Int J Med Sci), Vol. 12 (3): 256-63, 2015 .
Snippet: In contrast, HSPB6, HSPB7, HSPA6, HSPB2 and HSPB3 were upregulated in non-tumour tissues (all P < 0.001).
Affiliation: 1. Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China; 2. Department of Integrative Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; ; 3. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 4. NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool L69 3GA, UK. ; 5. Department of Molecular and Clinical Cancer Medicine, Institute of Translation medicine, University of Liverpool, Liverpool L69 3GA, UK. .
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17: Title: Gene expression of Hsps in normal and abnormal embryonic development of mouse hindlimbs.
Authors: Yan, Zhengli, et.al. .
Journal: Human & experimental toxicology (Hum Exp Toxicol), Vol. 34 (6): 563-74, 2015 .
Snippet: Our previous studies found that Hsp25, HspB2, HspB3, HspB7, Hsp20, HspB9, HspB10, and Hsp40 may be related to all-trans retinoic acid (atRA)-induced phocomelic and other abnormalities, while HspA12B, HspA14, Trap1, and Hsp105 may be forelimb development-related genes; Grp78 may play an important role in forelimb development.
Affiliation: Medical School, Hunan Normal University, Changsha, People's Republic of China. Department of Health Toxicology, Second Military Medical University, Shanghai, People's Republic of China. Department of Laboratory, No.100 Hospital of CPLA, Suzhou, People's Republic of China. Medical School, Hunan Normal University, Changsha, People's Republic of China njzhu70@126.com. Department of Health Toxicology, Second Military Medical University, Shanghai, People's Republic of China tbzhang2009@yeah.net. .
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18: Title: Expression and induction of small heat shock proteins in rat heart under chronic hyperglycemic conditions.
Authors: Reddy, V Sudhakar, et.al. .
Journal: Archives of biochemistry and biophysics (Arch Biochem Biophys), Vol. 558, 2014 .
Snippet: These results suggest up regulation of sHsp (MKBP, HspB3 and αBC), phosphorylation and translocation of Hsp27 and αBC to striated sarcomeres and impaired interaction of αBC and pS59-αBC with Bax under chronic hyperglycemia.
Affiliation: Biochemistry Division, National Institute of Nutrition, Hyderabad, India. Biochemistry Division, National Institute of Nutrition, Hyderabad, India. Electronic address: geereddy@yahoo.com. .
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19: Title: Neuropathy- and myopathy-associated mutations in human small heat shock proteins: Characteristics and evolutionary history of the mutation sites.
Authors: Benndorf, Rainer, et.al. .
Journal: Mutation research. Reviews in mutation research (Mutat Res Rev Mutat Res), 2014 .
Snippet: In HspB1, HspB3, and HspB8 all known mutations cause motor neuropathies, whereas in HspB5 they cause myopathies.
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20: Title: An exploration of heat tolerance in mice utilizing mRNA and microRNA expression analysis.
Authors: Islam, Aminul, et.al. .
Journal: PloS one, Vol. 8 (8): e72258, 2013 .
Snippet: Furthermore, we identified 61 distinct microRNA (miRNA) sequences significantly associated with TOL compared to INT mice; eight miRNAs corresponded to target sites in seven genes identified as being associated with heat tolerance pathways (Hspa1a, Dnajb1, Dnajb4, Dnajb6, Hspa2, Hspb3 and Hspb7).
Affiliation: Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America. aminul.islam@usuhs.edu .
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