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33 documents found
1: Title: The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors.
Authors: González, Betina, et.al. .
Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), Vol. 88, 2019 .
Snippet: Analysis of histone 3/4 enrichment at specific promoters revealed: i) distinct effects of the drugs on histone 3 acetylation, with modafinil increasing H3ac at Drd1 and Adra1b promoters, but METH increasing H3ac at Adra1a; ii) distinct effects on histone 4 acetylation enrichment, with modafinil increasing H4ac at the Drd2 promoter and decreasing it at Hrh1, but METH increasing H4ac at Drd1; iii) comparable effects of both psychostimulants, increasing H3ac at Drd2, Hcrtr1, and Hrh1 promoters, decreasing H3ac at Hrh3, increasing H4ac at Hcrtr1, and decreasing H4ac at Hcrtr2, Hrh3, and Grin1 promoters.
Affiliation: Instituto de Investigaciones Farmacológicas (Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Department of Behavioral Sciences, San Diego Mesa College, San Diego, California, United States. Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States. Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias (Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Instituto de Investigaciones Farmacológicas (Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Electronic address: verobisagno@gmail.com. .
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2: Title: Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.
Authors: Chen, Yongfeng, et.al. .
Journal: PloS one, Vol. 12 (12): e0189380, 2017 .
Snippet: Finally, we detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis.
Affiliation: Neuro-immunology Discovery Performance Unit, GSK, Shanghai, China. RD Platform Technology & Science, GSK, Shanghai, China. Genetics, Projects Clinical Platforms & Sciences, GSK, Stevenage, Herts, United Kingdom. Pathology, RD Platform Technology & Science, GSK, Research Triangle Park, NC, United States of America. Neuroinflammation DPU, Neurosciences TAU, GSK, Stevenage, Herts, United Kingdom. .
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3: Title: Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex.
Authors: González, Betina, et.al. .
Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), 2017 .
Snippet: We evaluated total H3ac, H4ac and 5-mC levels in the medial prefrontal cortex (mPFC), H3ac and H4ac promotor enrichment (ChIP) and mRNA expression (RT-PCR) of neurotransmitter systems involved in arousal, wakefulness and cognitive control, like dopaminergic (Drd1 and Drd2), α-adrenergic (Adra1a and Adra1b), orexinergic (Hcrtr1 and Hcrtr2), histaminergic (Hrh1 and Hrh3) and glutamatergic (AMPA Gria1 and NMDA Grin1) receptors.
Affiliation: Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States. Department of Behavioral Sciences, San Diego Mesa College, San Diego, CA, United States. Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Electronic address: vbisagno@ffyb.uba.ar. .
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4: Title: Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish.
Authors: Puttonen, H A J, et.al. .
Journal: Acta physiologica (Oxford, England) (Acta Physiol (oxf)), 2017 .
Snippet: RESULTS: We found that HRH3 knockout zebrafish larvae showed a shorter period of increased locomotion after a sudden onset of darkness, while the knockout larvae had a wild-type-like acute response to sudden darkness.
Affiliation: Neuroscience Center and Department of Anatomy, University of Helsinki, Helsinki, Finland. .
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5: Title: Affection of Comt1 genetype on anxiety and nociceptive sensitivity: an Ego-network analysis approach.
Authors: Li, Wenzheng, et.al. .
Journal: Molecular pain (Mol Pain), Vol. 13, 2017 Jan-Dec .
Snippet: Module 14 contained 10 genes, such as HRH3, DRD2, and CXCR3.
Affiliation: Department of Anesthesiology, Shouguang People Hospital, Weifang, 262700, China. .
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6: Title: Altered expression of histamine signaling genes in autism spectrum disorder.
Authors: Wright, C, et.al. .
Journal: Translational psychiatry (Transl Psychiatr), Vol. 7 (5): e1126, 2017 .
Snippet: There was no significant diagnosis effect on any of the individual HS genes but expression of the gene set of HNMT, HRH1, HRH2 and HRH3 was significantly altered.
Affiliation: Lieber Institute for Brain Development, Clinical Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. AstraZeneca Postdoc Program, Innovative Medicines and Early Development, Waltham, MA, USA. AstraZeneca Neuroscience, Innovative Medicines and Early Development, Waltham, MA, USA. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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7: Title: Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.
Authors: Tiwari, Arun K, et.al. .
Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (World J Biol Psychiatry), 2016 .
Snippet: OBJECTIVES: A positive correlation between antipsychotic-induced weight gain (AIWG) and the antagonist effect of antipsychotic drugs at the histamine H1 receptor (HRH1) as well as the agonist effect at the histamine H3 receptor (HRH3) in the brain has been consistently demonstrated.
Affiliation: a Neurogenetics Section, Neuroscience Department , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada. b Department of Psychiatry , University of Toronto , Toronto , ON , Canada. c Department of Psychiatry and Psychotherapy , Campus Mitte, Charité Universitätsmedizin Berlin , Berlin , Germany. d Department of Psychiatry, College of Physicians and Surgeons , Columbia University and the New York State Psychiatric Institute , New York City , NY , USA. e Northwestern University Feinberg School of Medicine , Chicago , IL , USA. .
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8: Title: Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats.
Authors: Sárvári, Miklós, et.al. .
Journal: Endocrinology, Vol. 158 (1): 69-83, 2017 .
Snippet: Downregulated clusters included neuropeptides and their receptors (Adcyap1, Cbln2, Cck, Cckbr, Crhr1 and 2, Oprd1, Nts, Penk, Sstr1, Vip), neurotransmitter signaling (Htr2c, Chrna3, Chrm4, Grm8, Hrh3, Slc17a6), and potassium channels (Kcnk9, Kcnj9, Kcnma1, Kcnc2).
Affiliation: Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, 1083 Budapest, Hungary; and. Department of Animal Hygiene, Herd-Health and Veterinary Ethology, University of Veterinary Medicine, 1078 Budapest, Hungary. .
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9: Title: Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP (Comp Biochem Phys C), Vol. 189, 2016 .
Snippet: We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream.
Affiliation: Sección de Microscopía, Servicio de Apoyo a la Investigación, University of Murcia, Murcia 30100, Spain. Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, IMIB-Arrixaca, 30100 Murcia, Spain. Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n. Puerto de Mazarrón, 30860 Murcia, Spain. Nutrigenomics and Fish Growth Endocrinology Group, Institute of Aquaculture of Torre la Sal, IATS-CSIC, 12595 Ribera de Cabanes, Castellón, Spain. Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n. Puerto de Mazarrón, 30860 Murcia, Spain. Electronic address: elena.chaves@mu.ieo.es. .
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10: Title: Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
Authors: He, Gong-Hao, et.al. .
Journal: BioMed research international (Biomed Res Int), Vol. 2016, 2016 .
Snippet: However, the relevance of polymorphisms in histamine-related genes, such as HRH2, HRH3, DAO, and HNMT, with CHF remains largely neglected.
Affiliation: Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China. Department of Cardio-Thoracic Surgery, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China. Surgery Center, 302 Hospital, Beijing 100039, China. Information Department, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China. Department of Pharmacy, The First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. .
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11: Title: Cimetidine and Clobenpropit Attenuate Inflammation-Associated Colorectal Carcinogenesis in Male ICR Mice.
Authors: Tanaka, Takuji, et.al. .
Journal: Cancers (Unknown Journal), Vol. 8 (2), 2016 .
Snippet: Because clobenpropit is also known to be a Hrh4 receptor agonist, Hrh2, Hrh3 and Hrh4 may be involved in inflammation-related colorectal carcinogenesis.
Affiliation: Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Gifu 500-8513, Japan. takutt@gmhosp.gifu.gifu.jp. Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. takutt@gmhosp.gifu.gifu.jp. Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. kottii924@yahoo.co.jp. Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. shirakamiyy@yahoo.co.jp. Department of Pharmacy, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki 503-8502, Japan. ta_mori04@yahoo.co.jp. Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Gifu 500-8513, Japan. mulmirry@yahoo.co.jp. Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. mulmirry@yahoo.co.jp. Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Gifu 500-8513, Japan. naoki@watanabe.name. Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. hmori@gifu-u.ac.jp. Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. shimim-gif@umin.ac.jp. .
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12: Title: On the Role of Histamine Receptors in the Regulation of Circadian Rhythms.
Authors: Rozov, Stanislav V, et.al. .
Journal: PloS one, Vol. 10 (12): e0144694, 2015 .
Snippet: Therefore, the knockout of Hrh1 receptor had no effects on the circadian rhythm of spontaneous locomotion, and a knockout of Hrh3 receptor caused a substantial reduction of free-running activity rhythm amplitude, but none of these knockout models affected the expression patterns of the core clock genes in any of the studied brain structures.
Affiliation: Neuroscience Center and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. .
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13: Title: Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease.
Authors: Møller, M Nue, et.al. .
Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol), Vol. 273 (7): 1705-10, 2016 .
Snippet: The combined results of microarrays and immuno-histochemistry showed expression of the histamine receptor HRH1 in the epithelial lining of the ES, whereas HRH3 was expressed exclusively in the sub-epithelial capillary network.
Affiliation: Department of Oto-rhino-laryngology, Head and Neck Surgery, and Audiology, Coepnhagen University Hospital Rigshospitalet, Copenhagen, Denmark. martin@nuemoller.dk. Department of Oral Medicine, Dental School, Panum Institute, University of Copenhagen, Copenhagen, Denmark. Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Oto-rhino-laryngology, Head and Neck Surgery, and Audiology, Coepnhagen University Hospital Rigshospitalet, Copenhagen, Denmark. .
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14: Title: Modulation of behavior by the histaminergic system: lessons from HDC-, H3R- and H4R-deficient mice.
Authors: Schneider, Erich H, et.al. .
Journal: Neuroscience and biobehavioral reviews (Neurosci Biobehav Rev), Vol. 47, 2014 .
Snippet: The phenotypes of Hdc(-/-)- and Hrh3(-/-) mice comprise behaviors related to locomotor activity, memory, cognition, anxiety, circadian rhythm, pain perception, food intake and addiction.
Affiliation: Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. Electronic address: schneider.erich@mh-hannover.de. Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. .
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15: Title: Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
Authors: He, Gong-Hao, et.al. .
Journal: PloS one, Vol. 9 (5): e97728, 2014 .
Snippet: The roles of polymorphisms in other histamine-related genes, such as histidine decarboxylase (HDC), histamine N-methyltransferase (HNMT) and histamine H3 receptor (HRH3), remain unexplored.
Affiliation: Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China. Department of neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. Department of Cardio-Thoracic Surgery, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China. Department of Pathology, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China. Department of Labour Hygiene, College of Military Preventive Medicine, Third Military Medical University, Chongqing, China. .
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16: Title: [Expression profile of genes associated with the histaminergic system estimated by oligonucleotide microarray analysis HG-U133A in women with endometrial adenocarcinoma].
Authors: Jeda, Agnieszka, et.al. .
Journal: Ginekologia polska (Ginekol Pol), Vol. 85 (3): 172-9, 2014 .
Snippet: Further analysis led to the identification of differentially expressed genes in grades G1, G2 and G3 of endometrial adenocarcinoma as compared to the control group, which were specific for each of the studied groups in grade G1 (CPA3), in grade G2 (HNMT LYN, DPT ITPKB, RASA4, APR RAB1 1FIP1, YWHAZ, VAMP8, RAB25) and in grade G3 (HRH3).
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17: Title: Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility.
Authors: Krementsov, Dimitry N, et.al. .
Journal: PloS one, Vol. 8 (7): e62743, 2013 .
Snippet: Histamine H(3) receptor (Hrh3/H(3)R) is primarily expressed by neurons in the central nervous system (CNS) where it functions as a presynaptic inhibitory autoreceptor and heteroreceptor.
Affiliation: Department of Medicine, Immunobiology Program, University of Vermont, Burlington, Vermont, USA. .
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18: Title: Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.
Authors: Karlstedt, K, et.al. .
Journal: British journal of pharmacology (Br J Pharmacol), Vol. 170 (1): 58-66, 2013 .
Snippet: CONCLUSIONS AND IMPLICATIONS: Both Hrh3 and Hrh4 receptors are expressed in rat brain endothelial cells, and activation of the histamine H4 receptor activates the Erk1/2 cascade.
Affiliation: Institute of Biomedicine, Physiology, Biomedicum Helsinki, University of Helsinki, Finland. .
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19: Title: Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies.
Authors: Surmiak, M, et.al. .
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society (J Physiol Pharmacol), Vol. 63 (3): 249-56, 2012 .
Snippet: In stimulated neutrophils we observed up-regulation of 13 genes (CCL2, CXCL2, VCAM1, MMP9, PLCB4, PDE4C, PLA2G4C, RAC1, RHOA, IRAK1, CACNA1D, CACNB2, PTGDR), further 11 genes were up-regulated only in some donors (IL13, PF4, IL2RG, ITGB1, CD83, PLA2G7, ALOX12, AXNA1, AXNA5, LTA4H, MCR2) yet two others (HRH3 and PLA2G2D) were up-regulated in a few samples and undetectable in others.
Affiliation: Division of Molecular Biology and Clinical Genetics, Department of Medicine, Jagiellonian University Medical College, Cracow, Poland. msanak@cm-uj.krakow.pl .
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20: Title: Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome.
Authors: Gunther, Joan, et.al. .
Journal: Psychiatry research (Psychiatry Res), Vol. 200 (2-3): 593-601, 2012 .
Snippet: Using GeneCards, PubMed, and manual curation, seven genes associated with TS were further examined: DRD2, HRH3, MAOB, BDNF, SNAP25, SLC6A4, and SLC22A3.
Affiliation: Department of Neurology and MIND Institute, University of California at Davis, 2805 50th Street, Sacramento, CA 95817, USA. joan.gunther@ucdmc.ucdavis.edu .
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