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138 documents found
1: Title: The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts.
Authors: Alsaleem, Mansour, et.al. .
Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol), 2019 .
Snippet: Reduced/loss E-cadherin expression was associated with differential expression of 2143 genes including those regulating Wnt (FZD2, GNG5, HLTF, WNT2, and CER1) and PIK3-AKT (FGFR2, GNF5, GNGT1, IFNA17, and IGF1) signaling pathways.
Affiliation: Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK. Faculty of Applied Medical Sciences, Onizah Community College, Qassim University, Qassim, Saudi Arabia. Faculty of Medicine, Menoufyia University, Shebin El Kom, Egypt. Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Department of Biology, Georgia State University, Atlanta, GA, USA. Cancer Biology and Translational Research, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK. Department of Pharmacology, Weill Cornell Medicine, New York, USA. Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK. Emad.Rakha@nottingham.ac.uk. Faculty of Medicine, Menoufyia University, Shebin El Kom, Egypt. Emad.Rakha@nottingham.ac.uk. .
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2: Title: A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination.
Authors: Takaoka, Kensuke, et.al. .
Journal: Leukemia, 2019 .
Snippet: Molecularly, we found that an E259K mutation reduced the binding capacity of HLTF with ubiquitin-conjugating enzymes, methanesulfonate sensitive 2 and ubiquitin-conjugating enzyme E2N, resulting in impaired polyubiquitination of proliferating cell nuclear antigen (PCNA) in HLTF E259K-transduced cells.
Affiliation: Department of Hematology and Oncology, The University of Tokyo, Tokyo, Japan. Department of Medical Genomics, The University of Tokyo, Tokyo, Japan. Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Department of Hematology, Tokyo Medical Center, Tokyo, Japan. Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan. Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan. Department of Hematology/Oncology, Gunma Children's Medical Center, Gunma, Japan. National Cancer Center Research Institute, Tokyo, Japan. Department of Hematology and Oncology, The University of Tokyo, Tokyo, Japan. kurokawa-tky@umin.ac.jp. .
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3: Title: Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism.
Authors: Takasawa, Shin, et.al. .
Journal: Immunologic research (Immunol Res), 2019 .
Snippet: The introduction of siRNA for MZF1, RTEF1/TEAD4, STAT3, and HLTF/FOXN2F abolished the transcription of REG Iα and REG Iβ.
Affiliation: Department of Biochemistry, Nara Medical University, Kashihara, 634-8521, Japan. shintksw@naramed-u.ac.jp. Department of Biochemistry, Nara Medical University, Kashihara, 634-8521, Japan. Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan. .
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4: Title: DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
Authors: Li, Jing, et.al. .
Journal: Experimental cell research (Exp Cell Res), Vol. 374 (2): 304-314, 2019 .
Snippet: We found that four E3 ubiquitin ligases (UHRF1, BRCA1, TRAIP and HLTF) and one regulator of ubiquitin E3 activity DCUN1D1 that were dramatically up-regulated in cancer were significantly associated with tumor metastasis and patient's poor prognosis both in two transcriptome data sets.
Affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Oncology, Huashan Hospital Fudan University, Shanghai, China. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: panhongyuabc@126.com. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: myao@shsci.org. .
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5: Title: Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway.
Authors: Masuda, Yuji, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 46 (21): 11340-11356, 2018 .
Snippet: By contrast, when PCNA was monoubiquitinated in the absence of HLTF, it was not polyubiquitinated by subsequently recruited HLTF unless all three-subunits of PCNA were monoubiquitinated, indicating that the uncoupling reaction specifically occurs on three-subunit-monoubiquitinated PCNA.
Affiliation: Department of Genome Dynamics, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8002, Japan. .
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6: Title: HLTF suppresses the migration and invasion of colorectal cancer cells via TGF‑β/SMAD signaling in vitro.
Authors: Liu, Li, et.al. .
Journal: International journal of oncology (Int J Oncol), Vol. 53 (6): 2780-2788, 2018 .
Snippet: With regard to the underlying molecular mechanisms, the protein expression of HTLF was upregulated when the CRC cells were stimulated with transforming growth factor (TGF)‑β, and HLTF upregulation induced an increase in SMAD4 and p‑SMAD2/3 expression and a decrease in levels of the TGF‑β/SMAD pathway downstream genes, Vimentin and zinc finger e‑box binding homeobox 1 (ZEB1).
Affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China. Department of Oncology, Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha, Hunan 410008, P.R. China. Department of Oncology, Zhuzhou No. 2 Hospital, Zhuzhou, Hunan 412005, P.R. China. Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China. .
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7: Title: Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.
Authors: Peng, Min, et.al. .
Journal: Cell reports (Cell Rep), Vol. 24 (12): 3251-3261, 2018 .
Snippet: Unexpectedly, the unrestrained DNA synthesis that characterizes HLTF-deficient cells is FANCJ dependent and correlates with S1 nuclease sensitivity and fork degradation.
Affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Department of Biology/VGN Proteomics Facility, University of Vermont, Burlington, VT 05405, USA. Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged 6726, Temesvari krt. 62, Hungary. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: sharon.cantor@umassmed.edu. .
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8: Title: High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.
Authors: Nightingale, Katie, et.al. .
Journal: Cell host & microbe (Cell Host Microbe), Vol. 24 (3): 447-460.e11, 2018 .
Snippet: This approach revealed that helicase-like transcription factor (HLTF), a DNA helicase important in DNA repair, potently inhibits early viral gene expression but is rapidly degraded during infection.
Affiliation: Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK. Cardiff University School of Medicine, Division of Infection and Immunity, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK. Regional Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty Kopec 7, 65653 Brno, Czech Republic. Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, 464 Bearsden Road, Glasgow G61 1QH, UK. Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK. Electronic address: mpw1001@cam.ac.uk. .
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9: Title: Differential genomics and transcriptomics between tyrosine kinase inhibitor-sensitive and -resistant BCR-ABL-dependent chronic myeloid leukemia.
Authors: Singh, Neetu, et.al. .
Journal: Oncotarget, Vol. 9 (54): 30385-30418, 2018 .
Snippet: A comparison between TKI-sensitive and TKI-resistant cases revealed up-regulation of LAPTM4B, HLTF, PIEZO2, CFH, CD109, ANGPT1 in CML-resistant cases, leading to up-regulation of autophagy-, protein-ubiquitination-, stem-cell-, complement-, TGFβ- and homeostasis-pathways with specific involvement of the Tie2 and Basigin signaling-pathway.
Affiliation: Molecular Biology Unit, Center for Advance Research, King George's Medical University, Lucknow, India. Department of Clinical Hematology, King George's Medical University, Lucknow, India. Department of Cardio Thoracic and Vascular Surgery, King George's Medical University, Lucknow, India. Systems Imagination, Scottsdale, Arizona, USA. Department of Periodontics, King George's Medical University, Lucknow, India. Department of Medicine, King George's Medical University, Lucknow, India. Department of Radiotherapy, King George's Medical University, Lucknow, India. All India Institute of Medical Sciences, Rishikesh, India. .
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10: Title: Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface.
Authors: Kaur, Gurvinder, et.al. .
Journal: PloS one, Vol. 13 (7): e0200211, 2018 .
Snippet: Our findings 1) prove the truncated Hltf protein isoform is a transcription factor, 2) establish a functional link between AS of Hltf and immunosuppression at the feto-maternal interface, 3) correlate intron retention with the absence of DNA methylation, and 4) underscore the importance of differential splicing analysis to identify Hltf's functional diversity.
Affiliation: Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America. Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America. Department of Cell Physiology & Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America. .
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11: Title: Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.
Authors: Elserafy, Menattallah, et.al. .
Journal: Trends in genetics : TIG (Trends Genet), 2018 .
Snippet: Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders.
Affiliation: Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt; These authors contributed equally to the manuscript. Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt; These authors contributed equally to the manuscript. Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt. Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt. Electronic address: s.el-khamisy@sheffield.ac.uk. .
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12: Title: Assessment of DNA repair susceptibility genes identified by whole exome sequencing in head and neck cancer.
Authors: Das, Raima, et.al. .
Journal: DNA repair (Dna Repair (amst)), Vol. 66-67, 2018 .
Snippet: The allelic association test suggested that the intronic variants in HLTF and RAD52 gene significantly associated (P < 0.05) with the risk (OR > 5), while intronic variants in PARP4, RECQL5, EXO1 and PER1 genes and exonic variant in TDP2 gene showed protection (OR < 1) for HNC.
Affiliation: Department of Biotechnology, Assam University, Silchar, 788011, Assam, India. Department of Biotechnology, Assam University, Silchar, 788011, Assam, India; University of Kalyani, Nadia, 741235, West Bengal, India. Electronic address: sankar.kumar.ghosh@aus.ac.in. .
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13: Title: Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC).
Authors: Dhont, Ludovic, et.al. .
Journal: BMC cancer, Vol. 18 (1): 429, 2018 .
Snippet: RESULTS: In silico analyses identified HLTF gene alterations more frequently in lung squamous cell carcinoma than in adenocarcinoma.
Affiliation: Laboratory of Molecular Biology, Research Institute for Health Sciences and Technology, Université de Mons, Mons, Belgium. Princess Margaret Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Cellular and Molecular Epigenetics, Université de Liège-GIGA, Liège, Belgium. Biostatistics Department, University of Toronto, Toronto, Canada. Université Libre de Bruxelles (ULB), Bruxelles, Belgium. Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, Canada. Department of Muldisciplinary Oncology and Therapeutic Innovations, Assistance Publique des Hôpitaux de Marseille (AP-HM), Aix-Marseille University, Chemin des Bourrely, 13195, Marseille, Cedex 20, France. celinejmmascaux@gmail.com. Centre de Recherche en Cancérologie de Marseille (CRCM, Cancer Research Center of Marseille), Inserm UMR1068, CNRS UMR7258 and Aix-Marseille University UM105, Marseille, France. celinejmmascaux@gmail.com. .
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14: Title: The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression.
Authors: Chavez, Diana A, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), 2018 .
Snippet: Helicase-like transcription factor (HLTF) is a central mediator of the DNA damage response and maintains genome stability by regressing stalled replication forks.
Affiliation: Vanderbilt University, United States. .
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15: Title: Differential expression profile of long non-coding RNAs in human thoracic aortic aneurysm.
Authors: Li, Yang, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), 2018 .
Snippet: Bioinformatics analysis showed 51.7% of differentially expressed lncRNAs were sense-overlapping, and most of the down-regulated lncRNAs were located on chromosome 1, 7, and 12. Subgroup analysis of TAA patients indicated that the expression of lnc-HLTF-5 was significantly higher in hypertension group than non-hypertension group (P < 0.05).
Affiliation: Institution of Cardiac Surgery, Department of Cardiovascular Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. Department of Cardiology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. Department of Cardiology, 98th Military Hospital, Huzhou, Zhejiang, China. .
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16: Title: Expression of REG family genes in human inflammatory bowel diseases and its regulation.
Authors: Tsuchida, Chikatsugu, et.al. .
Journal: Biochemistry and biophysics reports (Biochem Biophys Rep), Vol. 12, 2017 .
Snippet: The promoters contain consensus transcription factor binding sequences for MZF1, RTEF1/TEAD4, and STAT3 in REG Iα, and HLTF/FOXN2F in REG Iβ, respectively.
Affiliation: Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan. Saiseikai Nara Hospital, Nara 630-8145, Japan. Department of Diagnostic Pathology, Nara Medical University, Kashihara 634-8522, Japan. Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai 591-8025, Japan. Immunology Division, Germans Trias i Pujol Health Sciences Research Institute, Autonomous University of Barcelona, 08916 Badalona, Spain. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. .
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17: Title: HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase.
Authors: Zhou, Xiaohong, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (51): 21117-21127, 2017 .
Snippet: Mutational analyses suggest that Vpr interacts with DNA-binding residues in the N-terminal HIRAN domain of HLTF in a manner similar to the recruitment of another target, uracil DNA glycosylase (UNG2), to the CRL4-DCAF1 E3 by Vpr.
Affiliation: From the Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260 and. Department of Molecular Biology and Microbiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106. From the Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260 and jia12@pitt.edu. .
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18: Title: Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.
Authors: Wilkerson, Julia E R, et.al. .
Journal: Respiratory physiology & neurobiology (Respir Physiol Neurobiol), 2017 .
Snippet: Although moderate AIH also induces hypoglossal LTF (hLTF), no data are available concerning its sensitivity/insensitivity to the pattern of hypoxia.
Affiliation: Department of Comparative Biosciences University of Wisconsin Madison, WI, 53706, USA; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Department of Comparative Biosciences University of Wisconsin Madison, WI, 53706, USA; Department of Anesthesiology, Duke University, Durham, NC, 27710, USA. Department of Comparative Biosciences University of Wisconsin Madison, WI, 53706, USA; Center for Respiratory Research and Rehabilitation Department of Physical Therapy and McKnight Brain Institute University of Florida, Gainesville, FL, 32610, USA. Electronic address: gsmitche@phhp.ufl.edu. .
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19: Title: Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Authors: Taglialatela, Angelo, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 68 (2): 414-430.e8, 2017 .
Snippet: In addition to SMARCAL1, other SNF2-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability in BRCA1/2-deficient cells upon replication stress.
Affiliation: Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy. Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland. Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: ac3685@cumc.columbia.edu. .
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20: Title: ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells.
Authors: Piao, Shengfu, et.al. .
Journal: Autophagy, 2017 .
Snippet: Expression patterns of ALDH1A1 (aldehyde dehydrogenase 1 family member A1) and HLTF (helicase like transcription factor) identified HCQ-S (ALDH1A1high HLTFlow; ALDH1A1low HLTFlow) and HCQ-R (ALDH1A1low HLTFhigh) cells.
Affiliation: a Department of Medicine , University of Pennsylvania , Philadelphia , PA , USA. b Department of Chemistry , University of Pennsylvania , Philadelphia , PA , USA. c Center for Clinical Epidemiology and Biostatistics , University of Pennsylvania , Philadelphia , PA , USA. d Department of Cancer Biology , University of Pennsylvania , Philadelphia , PA , USA. e Abramson Cancer Center , University of Pennsylvania , Philadelphia , PA , USA. .
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