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63 documents found
1: Title: HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain.
Authors: Deng, Qingfu, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 19 (3): 2115-2124, 2019 .
Snippet: In the present study, HepaCAM, androgen receptor (AR) and Ran were analysed in 46 PCa tissue samples using immunohistochemistry. Subsequently, the influence of HepaCAM and its cytoplasmic domain on cell proliferation, migration, and invasion, and associated proteins was examined using MTT, wound healing, Transwell and western blotting assays, respectively.
Affiliation: Department of Urology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, P.R. China. Key Laboratory of Diagnostics Medicine Designated by The Ministry of Education, Chongqing Medical University, Chongqing 400042, P.R. China. .
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2: Title: HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
Authors: Fan, Yanru, et.al. .
Journal: Urology, Vol. 127, 2019 .
Snippet: MATERIALS AND METHODS: The expression of hepaCAM and HIF-1α in RCC tissue samples was examined by immunohistochemistry. Glucose consumption and lactate production assays were used to detect metabolic activity in RCC cell lines.
Affiliation: Chongqing Medical University, Chongqing, China. First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Chongqing Medical University, Chongqing, China. Electronic address: 903940327@qq.com. .
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3: Title: Identification of Critical Genes and Five Prognostic Biomarkers Associated with Colorectal Cancer.
Authors: Huang, Zuoliang, et.al. .
Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit), Vol. 24, 2018 .
Snippet: MATERIAL AND METHODS A total of 116 normal mucous tissue and 930 CRC tissue datasets were downloaded from the Gene Expression Omnibus database (GEO) and The Cancer Genome Atlas (TCGA).
Affiliation: School of Medical Laboratory, Shao Yang University, Shaoyang, Hunan, China (mainland). .
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4: Title: HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro.
Authors: Du, Zhongbo, et.al. .
Journal: International journal of oncology (Int J Oncol), Vol. 53 (1): 99-112, 2018 .
Snippet: In this study, we found that the activities of Notch signaling were elevated, while HepaCAM expression was decreased in CRPC tissues compared with matched primary prostate cancer (PPC) tissues.
Affiliation: Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China. Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China. .
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5: Title: Megalencephalic Leukoencephalopathy with Subcortical Cysts
Authors: van der Knaap, Marjo S, et.al. .
Publisher: University of Washington, Seattle GeneReviews(®)
Snippet: The improving phenotype associated with heterozygous mutation of HEPACAM is known as MLC2B.
Affiliation: Professor, Department of Child Neurology, Vrije Universiteit Medical Center, Amsterdam, Netherlands Assistant Professor, Pediatrics and Child Neurology, Vrije Universiteit Medical Center, Amsterdam, Netherlands .
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6: Title: Comprehensive molecular biomarker identification in breast cancer brain metastases.
Authors: Schulten, Hans-Juergen, et.al. .
Journal: Journal of translational medicine (J Transl Med), Vol. 15 (1): 269, 2017 .
Snippet: WES detected numerous mutations, some of which affecting BC associated genes as CDH1, HEPACAM, and LOXHD1.
Affiliation: Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia. hschulten@kau.edu.sa. Division of Neurosurgery, Department of Surgery, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia. King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. Department of Pathology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Department of Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. .
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7: Title: Glucocorticoids, genes and brain function.
Authors: Juszczak, Grzegorz R, et.al. .
Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), 2017 .
Snippet: Other genes are involved in the regulation of metabolism (Gpd1, Aldoc and Pdk4), actin cytoskeleton (Myh2, Nedd9, Mical2, Rhou, Arl4d, Osbpl3, Arhgef3, Sdc4, Rdx, Wipf3, Chst1 and Hepacam), autophagy (Eva1a and Plekhf1), vesicular transport (Rhob, Ehd3, Vps37b and Scamp2), gap junctions (Gjb6), immune response (Tiparp, Mertk, Lyve1 and Il6r), signaling mediated by thyroid hormones (Thra and Sult1a1), calcium (Calm2), adrenaline/noradrenaline (Adcy9 and Adra1d), neuropeptide Y (Npy1r) and histamine (Hdc).
Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552 Magdalenka, Poland. Electronic address: g.juszczak@ighz.pl. Department of Molecular Biology, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552 Magdalenka, Poland. .
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8: Title: Megalencephalic leukoencephalopathy with subcortical cysts: A personal biochemical retrospective.
Authors: Estévez, Raúl, et.al. .
Journal: European journal of medical genetics (Eur J Med Genet), Vol. 61 (1): 50-60, 2018 .
Snippet: MLC1 is a membrane protein with low identity to the Kv1.1 potassium channel and GlialCAM belongs to an adhesion molecule family.
Affiliation: Unitat de Fisiologia, Departament de Ciències Fisiològiques, IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), ISCIII, Spain. Electronic address: restevez@ub.edu. Unitat de Fisiologia, Departament de Ciències Fisiològiques, IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), ISCIII, Spain. Unitat de Fisiologia, Departament de Ciències Fisiològiques, IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain. Unitat de Fisiologia, Departament de Ciències Fisiològiques, IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Unitat de Genètica, Departament de Ciències Fisiològiques, Laboratori de Genètica Molecular, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), ISCIII, Spain. Unitat de Fisiologia, Departament de Ciències Fisiològiques, IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Unitat de Genètica, Departament de Ciències Fisiològiques, Laboratori de Genètica Molecular, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat, Spain. Centro de Investigación en Red de Enfermedades Raras (CIBERER), ISCIII, Spain; Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain. Unitat de Genètica, Departament de Ciències Fisiològiques, Laboratori de Genètica Molecular, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), ISCIII, Spain. .
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9: Title: Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells.
Authors: Geng, Hai-Tao, et.al. .
Journal: Oncology research (Oncol Res), Vol. 25 (7): 1039-1046, 2017 .
Snippet: We also demonstrated that overexpression of hepaCAM reduced the protein expression levels of β-catenin, cyclin D1, and c-Myc, indicating its inhibitory effect on the Wnt/β-catenin signaling pathway.
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10: Title: Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
Authors: Tang, Min, et.al. .
Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol), Vol. 143 (5): 793-805, 2017 .
Snippet: We found that the combined treatment of HepaCAM-overexpressing adenovirus with the PI3K inhibitor LY294002 enhanced the inhibitory effects on cell proliferation, viability and protein expression.
Affiliation: The Key Laboratory of Diagnostics Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China. The Key Laboratory of Diagnostics Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China. luochunli79@126.com. .
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11: Title: Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Authors: Quan, Zhen, et.al. .
Journal: Cellular signalling (Cell Signal), Vol. 32, 2017 .
Snippet: Hepatocyte cell adhesion molecule (hepaCAM) is a novel tumor suppressor, which is lost or down-regulated in many cancer types including RCC.
Affiliation: Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. Department of Laboratory Diagnosis, Chongqing Medical University, Chongqing, People's Republic of China. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. Electronic address: framework1221@163.com. .
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12: Title: HepaCAM associates with connexin 43 and enhances its localization in cellular junctions.
Authors: Wu, Meihui, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Mutations in HEPACAM give rise to the neurodegenerative disease megalencephalic leukoencephalopathy with subcortical cysts (MLC) since mutated hepaCAM prevents shuttling of MLC1 protein to astrocytic junctions in the plasma membrane.
Affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597. Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117456. .
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13: Title: Megalencephalic leukoencephalopathy with cysts in twelve Egyptian patients: novel mutations in MLC1 and HEPACAM and a founder effect.
Authors: Abdel-Salam, Ghada M H, et.al. .
Journal: Metabolic brain disease (Metab Brain Dis), Vol. 31 (5): 1171-9, 2016 .
Snippet: Here, we identified MLC1 and HEPACAM mutations in ten and two patients, respectively.
Affiliation: Clinical Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Tahrir street, Dokki, Cairo, Egypt. ghada.abdelsalam@yahoo.com. Centre of Excellence for Human Genetics, National Research Centre, Cairo, Egypt. ghada.abdelsalam@yahoo.com. Centre of Excellence for Human Genetics, National Research Centre, Cairo, Egypt. Medical Molecular Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt. Clinical Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Tahrir street, Dokki, Cairo, Egypt. National Institute of Neuromotor system, Cairo, Egypt. Department of Pediatrics, Alexandria University, Alexandria, Egypt. .
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14: Title: Ten Novel Mutations in Chinese Patients with Megalencephalic Leukoencephalopathy with Subcortical Cysts and a Long-Term Follow-Up Research.
Authors: Cao, Binbin, et.al. .
Journal: PloS one, Vol. 11 (6): e0157258, 2016 .
Snippet: 19(95%) were genetically diagnosed with 10 novel mutations in MLC1, MLC1 and GlialCAM mutations were identified in 15 and 4 patients, respectively.
Affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Department of Pediatrics, Beijing Tian Tan Hospital, Capital Medical University Beijing 100050, China. Department of Radiology, Peking University First Hospital, Beijing 100034, China. Department of Neurology, Shanxi Dayi Hospital, Taiyuan 030000, Shanxi Province, China. Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China. .
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15: Title: de novo interstitial deletions at the 11q23.3-q24.2 region.
Authors: Su, Jiasun, et.al. .
Journal: Molecular cytogenetics (Unknown Journal), Vol. 9, 2016 .
Snippet: The deletion at 11q24.2 involves HEPACAM and our patient's clinical presentation (relative macrocephaly, abnormal MRI, mild developmental delay and seizure) is not inconsistent with Megalencephalic leukoencephalopathy with subcortical cysts 2B.
Affiliation: Department of Genetic and Metabolic Central Laboratory, Guangxi Maternal and Child Health Hospital, No59 Xiangzhu Road, Nanning, China. Department of Genetic and Metabolic Central Laboratory, Guangxi Maternal and Child Health Hospital, No59 Xiangzhu Road, Nanning, China ; Department of Laboratory Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115 USA. .
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16: Title: The SMAD2/3 pathway is involved in hepaCAM-induced apoptosis by inhibiting the nuclear translocation of SMAD2/3 in bladder cancer cells.
Authors: Wang, Xiaorong, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (8): 10731-43, 2016 .
Snippet: Western blot was employed to determine the expression of hepaCAM and SMAD2/3/caspase pathway molecules using a hepaCAM overexpression adenovirus, a caspase inhibitor (Z-VAD-FMK), and a SMAD2/3 activator (transforming growth factor (TGF)-β1), respectively.
Affiliation: The Key Laboratory of Diagnostics Medicine, Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China. The Key Laboratory of Diagnostics Medicine, Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China. luochunli79@126.com. .
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17: Title: 5-azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene.
Authors: Wang, Xiaorong, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 35 (3): 1375-84, 2016 .
Snippet: Hepatocyte cell adhesion molecule (hepaCAM), a tumor-suppressor gene, is rarely expressed in bladder carcinoma.
Affiliation: Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, P.R. China. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China. .
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18: Title: HEPACAM inhibited the growth and migration of cancer cells in the progression of non-small cell lung cancer.
Authors: Shao, Huanzhang, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (2): 2621-7, 2016 .
Snippet: Hepatocyte cell adhesion molecule (HEPACAM), a member of immunoglobulin superfamily, is an adhesion molecule.
Affiliation: Department of Critical Care Medicine, Henan Provincial People's Hospital, Affiliated of Zhengzhou University, Zhengzhou, 450003, China. Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, 214200, Jiangsu Province, China. Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu Province, China. Department of Medical Oncology, Wujin People's Hospital Affiliated to Jiangsu University, 2 North Yongning Rd, Changzhou, 213002, Jiangsu Province, China. luwenbin0716@sina.com. .
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19: Title: Leukoencephalopathy associated with 11q24 deletion involving the gene encoding hepatic and glial cell adhesion molecule in two patients.
Authors: Yamamoto, Toshiyuki, et.al. .
Journal: European journal of medical genetics (Eur J Med Genet), Vol. 58 (9): 492-6, 2015 .
Snippet: Mutations of the gene encoding hepatic and glial cell adhesion molecule (HEPACAM) located on 11q24 are related to one of the leukoencephalopathies: megalencephalic leukoencephalopathy with subcortical cysts type 2 (MLC2).
Affiliation: Tokyo Women's Medical University Institute for Integrated Medical Sciences, Tokyo, Japan; Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: yamamoto.toshiyuki@twmu.ac.jp. Tokyo Women's Medical University Institute for Integrated Medical Sciences, Tokyo, Japan; Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan. Tokyo Women's Medical University Institute for Integrated Medical Sciences, Tokyo, Japan. Department of Clinical Genetics, Kurashiki Central Hospital, Kurashiki, Japan. Division of Neurology, National Center for Child Health and Development, Tokyo, Japan. .
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20: Title: Expression of hepaCAM inhibits bladder cancer cell proliferation via a Wnt/β-catenin-dependent pathway in vitro and in vivo.
Authors: Du, Hong-Fei, et.al. .
Journal: Cancer biology & therapy (Cancer Biol Ther), Vol. 16 (10): 1502-13, 2015 .
Snippet: Here, Our researches showed that hepaCAM played a central role in modulating the Wnt/β-catenin signaling pathway by interfering nuclear protein levels of β-catenin, leading to down-regulate transcriptional activity of LEF/TCF and its target genes c-Myc and cyclinD1.
Affiliation: a Department of Clinical Laboratory ; The First Affiliated Hospital of Chengdu Medical College ; Chengdu , PR China. b The Key Laboratory of Diagnostics Medicine designated by the Ministry of Education ; Chongqing Medical University ; Chongqing , PR China. c Department of Laboratory Medicine ; Shang qiu Medical College ; Shang qiu , PR China. d Department of Urology , The First Affiliated Hospital of Chongqing Medical University ; Chongqing , PR China. .
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