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24 documents found
1: Title: Glypicans as Cancer Therapeutic Targets.
Authors: Li, Nan, et.al. .
Journal: Trends in cancer (Trends Cancer), Vol. 4 (11): 741-754, 2018 .
Snippet: Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC3), are expressed in childhood cancers and liver cancers, respectively.
Affiliation: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: homi@mail.nih.gov. .
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2: Title: Molecular network-based identification of competing endogenous RNAs and mRNA signatures that predict survival in prostate cancer.
Authors: Xu, Ning, et.al. .
Journal: Journal of translational medicine (J Transl Med), Vol. 16 (1): 274, 2018 .
Snippet: After the univariate and multivariate Cox regression analyses, 4 mRNAs (HOXB5, GPC2, PGA5, and AMBN) were screened and used to establish a predictive model for the overall survival of patients.
Affiliation: Department of Urology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Rd., Yuzhong District, Chongqing, 400016, China. Departments of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Rd., Yuzhong District, Chongqing, 400016, China. gouxincq@163.com. .
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3: Title: Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.
Authors: Bosse, Kristopher R, et.al. .
Journal: Cancer cell, Vol. 32 (3): 295-309.e12, 2017 .
Snippet: We demonstrate high GPC2 expression in neuroblastoma due to MYCN transcriptional activation and/or somatic gain of the GPC2 locus.
Affiliation: Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA. Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA. Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA. Division of Neurosurgery and the Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Genome Sciences Center, British Columbia Cancer Agency, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA. Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: maris@chop.edu. .
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4: Title: Scratching the Surface of Immunotherapeutic Targets in Neuroblastoma.
Authors: Malone, Clare F, et.al. .
Journal: Cancer cell, Vol. 32 (3): 271-273, 2017 .
Snippet: report GPC2 as a therapeutic target in neuroblastoma.
Affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address: kimberly_stegmaier@dfci.harvard.edu. .
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5: Title: Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma.
Authors: Li, Nan, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (32): E6623-E6631, 2017 .
Snippet: To explore GPC2 as a potential target in neuroblastoma, we have developed two forms of antibody therapeutics, immunotoxins and chimeric antigen receptor (CAR) T cells.
Affiliation: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; homi@mail.nih.gov. .
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6: Title: Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis.
Authors: Lugert, S, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: Therefore, we performed an unbiased proteomics screen to identify novel proteins expressed during neuronal differentiation using a human neural stem cell model, and we identified the proteoglycan Glypican-2 (Gpc2) as a putative secreted marker of immature neurons.
Affiliation: Roche Pharmaceutical Research and Early Development, NORD Discovery &Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland. Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland. Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland. CESP/UMR-S 1178, Univ. Paris-Sud, Fac. Pharmacie, INSERM, Université Paris-Saclay, Chatenay Malabry, 92290, France. Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland. .
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7: Title: Optimization of post-cervical artificial insemination in gilts: Effect of cervical relaxation procedures and catheter type.
Journal: Theriogenology, Vol. 90, 2017 .
Snippet: In the second experiment, new catheters based on the anatomical characteristics of gilts (GpC) were used, and the rate of successful pC-AI application were compared (experiment 2a): a) MpC: control; b) GpC1: multi-ring catheter of Ø 16 mm and inner cannula of Ø 3.5 mm; c) GpC2: a multi-ring catheter of Ø with an inner cannula of Ø 2.5 mm.
Affiliation: Department of Physiology, Faculty of Veterinary Science, University of Murcia, Murcia, Spain; Boehringer-Ingelheim, Spain. Department of Physiology, Faculty of Veterinary Science, University of Murcia, Murcia, Spain. Department of Cell Biology and Histology, Faculty of Medicine, University of Murcia, Murcia, Spain; International Excellence Campus for Higher Education and Research (Campus Mare Nostrum), Spain; Institute for Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain. Department of Physiology, Faculty of Veterinary Science, University of Murcia, Murcia, Spain; International Excellence Campus for Higher Education and Research (Campus Mare Nostrum), Spain; Institute for Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain. Universidad Católica de Valencia, Valencia, Spain. Department of Physiology, Faculty of Veterinary Science, University of Murcia, Murcia, Spain; International Excellence Campus for Higher Education and Research (Campus Mare Nostrum), Spain; Institute for Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain. Electronic address: fagarcia@um.es. .
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8: Title: Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination.
Authors: Oikari, Lotta E, et.al. .
Journal: Stem cell research (Stem Cell Res), Vol. 16 (1): 92-104, 2016 .
Snippet: Furthermore, neuronal differentiation of the cells upregulated SDC4, GPC1, GPC2, GPC3 and GPC6 expression with increased GPC4 expression observed under astrocyte culture conditions.
Affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia. Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia. Electronic address: larisa.haupt@qut.edu.au. .
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9: Title: Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors.
Authors: Farnedi, Anna, et.al. .
Journal: BMC cancer, Vol. 15, 2015 .
Snippet: RESULTS: HNSCC lesions were indeed found to exhibit a widely aberrant PG expression pattern characterized by a variable expression of all PGs and a characteristic de novo transcription/translation of GPC2, GPC5 and NG2/CSPG4 respectively in 36%, 72% and 71% on 119 cases.
Affiliation: Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology, University of Bologna, Bellaria Hospital, Bologna, Italy. farnedi@hotmail.com. COMT - Centre for Molecular Translational Oncology & Department of Life Sciences, University of Parma, Parma, Italy. silvia.rossi1@unipr.it. COMT - Centre for Molecular Translational Oncology & Department of Life Sciences, University of Parma, Parma, Italy. nicoletta.bertani@unipr.it. Department of Life Sciences, Division of Genetics and Environmental Biotechnology, University of Parma, Parma, Italy. mariolina.gulli@unipr.it. COMT - Centre for Molecular Translational Oncology & Department of Life Sciences, University of Parma, Parma, Italy. enricomaria.silini@unipr.it. Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy. enricomaria.silini@unipr.it. S.O.C. of Experimental Oncology 2, The National Tumour Institute Aviano - CRO-IRCCS, Aviano, Pordenone, Italy. mtmucignat@cro.it. Maxillofacial Surgery Section, Head and Neck Department, University of Parma, Parma, Italy. tito.poli@unipr.it. Maxillofacial Surgery Section, Head and Neck Department, University of Parma, Parma, Italy. enrico.sesenna@unipr.it. Maxillofacial Surgery Section, Head and Neck Department, University of Parma, Parma, Italy. lanfranco82@yahoo.it. Unit of Maxillo-Facial Surgery, Department of Oral Sciences, University of Bologna, Bellaria Hospital, Bologna, Italy. lucio.montebugnoli@unibo.it. Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology, University of Bologna, Bellaria Hospital, Bologna, Italy. elisa.leonardi4@unibo.it. Department of Biomedical and Neuromotor Sciences, Unit of Maxillo-Facial Surgery, University of Bologna, S. Orsola Hospital, Bologna, Italy. claudio.marchetti@unibo.it. Unit of Maxillo-facial Surgery at Bellaria Hospital, Bologna, Italy. roberto.cocchi@ausl.bologna.it. Unit of Maxillo-facial Surgery, "Casa Sollievo della Sofferenza", San Giovanni in Rotondo, Italy. roberto.cocchi@ausl.bologna.it. Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology, University of Bologna, Bellaria Hospital, Bologna, Italy. andreaambrosini@yahoo.it. Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology, University of Bologna, Bellaria Hospital, Bologna, Italy. mariapia.foschini@unibo.it. COMT - Centre for Molecular Translational Oncology & Department of Life Sciences, University of Parma, Parma, Italy. roberto.perris@unipr.it. S.O.C. of Experimental Oncology 2, The National Tumour Institute Aviano - CRO-IRCCS, Aviano, Pordenone, Italy. roberto.perris@unipr.it. .
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10: Title: Regulation of Zn and Fe transporters by the GPC1 gene during early wheat monocarpic senescence.
Authors: Pearce, Stephen, et.al. .
Journal: BMC plant biology (Bmc Plant Biol), Vol. 14, 2014 .
Snippet: We have previously shown that the simultaneous downregulation of Grain Protein Content (GPC) transcription factors, GPC1 and GPC2, greatly delays senescence and disrupts nutrient remobilization, and therefore provide a valuable entry point to identify genes involved in micronutrient transport to the wheat grain.
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11: Title: Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers.
Authors: Orentas, Rimas J, et.al. .
Journal: Frontiers in oncology (Front Oncol), Vol. 2, 2012 .
Snippet: Moreover, several potential new targets shared among several pediatric solid tumors are herein identified, such as MCAM (MUC18), metadherin (MTDH), and glypican-2 (GPC2).
Affiliation: Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD, USA. .
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12: Title: Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice.
Journal: Journal of ethnopharmacology (J Ethnopharmacol), Vol. 133 (3): 1077-84, 2011 .
Snippet: This work aimed to evaluate the anti-inflammatory action of its ethanol (EEGP) extract, ethyl acetate (EA), dichloromethane (DCM), petroleum ether (PE) butanolic (BT) fractions, and the isolated compounds bauerenyl acetate (GPC1) and 11,13-dihydrozaluzanin C (GPC2).
Affiliation: Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, PR, Brazil. .
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13: Title: The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.
Authors: Lehtonen, Sanna, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 19 (7): 2949-61, 2008 .
Snippet: ARH interacts with centrosomal (gamma-tubulin and GPC2 and GPC3) and motor (dynein heavy and intermediate chains) proteins.
Affiliation: Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. .
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14: Title: Bacteria and bacterial rRNA genes associated with the development of colitis in IL-10(-/-) mice.
Authors: Ye, Jingxiao, et.al. .
Journal: Inflammatory bowel diseases (Inflamm Bowel Dis), Vol. 14 (8): 1041-50, 2008 .
Snippet: CONCLUSIONS: The negative associations of these 2 phylotypes (GpC2 and Gp66) suggest that these bacteria were being immunologically targeted, consistent with prior findings that the Lachnospiraceae bacterium A4 bears a prevalent flagellar antigen for disease-associated immunity in murine immune colitis and human Crohn's disease.
Affiliation: Department of Plant Pathology and Microbiology, University of California, Riverside, California 92521, USA. .
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15: Title: Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney.
Authors: Steer, Dylan L, et.al. .
Journal: Developmental biology (Dev Biol), Vol. 272 (2): 310-27, 2004 .
Snippet: Glycosaminoglycans in the form of heparan sulfate proteoglycans (HSPG) and chondroitin sulfate proteoglycans (CSPG) are required for normal kidney organogenesis.
Affiliation: Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA. .
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16: Title: Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth.
Authors: Kurosawa, N, et.al. .
Journal: Glycoconjugate journal (Glycoconjugate J), Vol. 18 (6): 499-507, 2001 .
Snippet: Ligation of cell-surface glypican-2 with MK or an antibody against epitope-tagged glypican-2 induced cell adhesion and promoted neurite outgrowth.
Affiliation: Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Japan. kurosawa@eng.toyama-u.ac.jp .
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17: Title: Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones.
Authors: Ivins, J K, et.al. .
Journal: Developmental biology (Dev Biol), Vol. 184 (2): 320-32, 1997 .
Snippet: Cerebroglycan is a glycosylphosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found exclusively in the developing nervous system.
Affiliation: Department of Cell and Developmental Biology, University of California at Irvine, 92697, USA. jkivins@UCI.edu .
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18: Title: Differential regulation of neuronal proteoglycans by activation of excitatory amino acid receptors.
Authors: Wang, W, et.al. .
Journal: Neuroreport, Vol. 8 (3): 659-63, 1997 .
Snippet: We have previously shown that glutamate activation of excitatory amino acid receptors induces the synthesis and release of PGs with neurite-promoting activity from hippocampal neurones.
Affiliation: Department of Pediatrics, Queen's University, Kingston, Ontario, Canada. .
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19: Title: Molecular characterization and promoter analysis of the maize cytosolic glyceraldehyde 3-phosphate dehydrogenase gene family and its expression during anoxia.
Authors: Manjunath, S, et.al. .
Journal: Plant molecular biology (Plant Mol Biol), Vol. 33 (1): 97-112, 1997 .
Snippet: Maize cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPC) is encoded by a small multi-gene family consisting of gpc1, gpc2, gpc3 and gpc4.
Affiliation: Department of Crop Sciences, University of Illinois, Urbana 61801, USA. .
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20: Title: Developmental and FGF-2-mediated regulation of syndecans (1-4) and glypican in oligodendrocytes.
Authors: Bansal, R, et.al. .
Journal: Molecular and cellular neurosciences (Mol Cell Neurosci), Vol. 7 (4): 276-88, 1996 .
Snippet: Differentiating cells undergo developmentally regulated changes in cell-cell and cell-matrix adhesion that control migration through microenvironments, proliferation, and differentiation.
Affiliation: Department of Microbiology, University of Connecticut School of Medicine, Farmington 06030, USA. .
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