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37 documents found
1: Title: Sexual dimorphism in the expression of GKN2 and FOXA2 genes in the human stomach.
Authors: Mohammadi, Reza, et.al. .
Journal: Molecular biology reports (Mol Biol Rep), 2019 .
Snippet: The results indicated that the expression levels of both the GKN2 (7.2-fold, p < 0.001) and FOXA2 (3.7-fold, p = 0.003) were significantly higher in men compared to those in women.
Affiliation: Department of Biology, Faculy of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. Imam Ali Hospital, Farokhshar, Shahrekord, Iran. Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran. Shiraz Molecular Pathology Research Center, Dr Daneshbod Pathol Lab, Shiraz, Iran. Biotechnology Research Inistitute, Shahrekord University, Shahrekord, Iran. Department of Genetics, School of Medicine, Kazerun Branch, Islamic Azad University, P.O. Box: 73135-168, Kazerun, Iran. mehdimoghani@yahoo.com. .
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2: Title: Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer.
Authors: Dokhaee, Fatemeh, et.al. .
Journal: Gastroenterology and hepatology from bed to bench (Gastroenterol Hepatol Bed Bench), Vol. 11 (Suppl 1): S140-S145, 2018 .
Snippet: Aim: The aim of this study was to investigate the expression of GKN1 and GKN2 genes as probable biomarkers for gastric cancer.
Affiliation: Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran. Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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3: Title: Global transcriptome‑wide analysis of the function of GDDR in acute gastric lesions.
Authors: Zhang, Ziqiang, et.al. .
Journal: Molecular medicine reports (Mol Med Report), 2017 .
Snippet: Based on the GO analysis, the upregulated DEGs were distinctly enriched in muscle contraction and response to wounding; and the downregulated DEGs were significantly enriched in the regulation of nitrogen compound metabolic process and regulation of RNA metabolic process.
Affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China. Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China. .
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4: Title: Gastrokine mRNA expression in gastric tissue from dogs with helicobacter colonisation but without inflammatory change during treatment.
Authors: Sharman, M J, et.al. .
Journal: Veterinary immunology and immunopathology (Vet Immunol Immunopathol), Vol. 187, 2017 .
Snippet: Further evaluation is required to determine the relevance of this finding, however given a suspected role in gastric homeostasis, up-regulation of GKN1 and GKN2 could limit development of gastritis in Helicobacter spp.
Affiliation: Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: melloras@alumni.unimelb.edu.au. Faculty of Veterinary and Agricultural Science, The University of Melbourne, Werribee, Victoria, Australia. .
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5: Title: GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK/STAT signaling pathway.
Authors: Ouyang, Jun, et.al. .
Journal: American journal of translational research (Unknown Journal), Vol. 9 (2): 803-811, 2017 .
Snippet: OBJECTIVES: To investigate the effect of gastric motility protein 2 (GKN2) on the proliferation, apoptosis and invasion of gastric cancer cell and on the JAK/signal transducer and activator of transcription 3 (STAT3) signaling pathway.
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital of University of South China Hunan, China. Department of Urology, The First Affiliated Hospital of University of South China Hunan, China. Department of Pathology, University of South China Hunan, China. .
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6: Title: Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells.
Authors: Kim, Olga, et.al. .
Journal: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (Gastric Cancer), 2017 .
Snippet: RESULTS: Co-transfection with GKN2 and TFF1 significantly inhibited cell viability and proliferation by inducing G1/S cell cycle arrest and suppressing positive cell cycle regulators.
Affiliation: Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea. Department of Medicine, Howard University, Washington, DC, 20060, USA. Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea. wonsang@catholic.ac.kr. .
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7: Title: Identification of novel genetic markers for mouse yolk sac cells by using microarray analyses.
Authors: Yagi, Shinomi, et.al. .
Journal: Placenta, Vol. 49, 2017 .
Snippet: Gkn2 and Pga5 were selected as markers for PYS cells.
Affiliation: Graduate School of Science and Technology, Shizuoka University, Oya 836, Suruga-ku, Shizuoka City, Shizuoka 422-8529, Japan. Graduate School of Science and Technology, Shizuoka University, Oya 836, Suruga-ku, Shizuoka City, Shizuoka 422-8529, Japan. Electronic address: shiojiri.nobuyoshi@shizuoka.ac.jp. .
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8: Title: Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3β signaling in gastric cancer.
Authors: Dai, Jin, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (9): 12403-12410, 2016 .
Snippet: Taken together, these findings suggested that GKN2 suppressed epithelial mesenchymal transition of gastric cancer cells by downregulation of snail through PI3K/AKT/GSK3β signaling pathway.
Affiliation: Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China. Division of Gastroenterology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, 550002, China. Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China. chenminhu@vip.163.com. Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China. chen0jie@hotmail.com. .
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9: Title: Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal.
Authors: Fang, Cheng, et.al. .
Journal: Digestive diseases and sciences (Dig Dis Sci), Vol. 61 (7): 1941-9, 2016 .
Snippet: Moreover, GDDR had an inhibitory effect on PI3K/Akt signaling pathway.
Affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, China. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. Department of Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, China. dujjp@hotmail.com. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. dujjp@hotmail.com. .
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10: Title: Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 126 (4): 1383-400, 2016 .
Snippet: Heightened Th1 responses in Gkn2 knockout mice were linked to deregulated mucosal innate immunity and impaired myeloid-derived suppressor cell activation.
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11: Title: A possible role of GDDR in the development of Helicobacter pylori-associated gastric cancer.
Authors: Zhao, Zhanwei, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (8): 10303-15, 2016 .
Snippet: GDDR has been confirmed as a tumor suppressor gene in gastric tumorigenesis.
Affiliation: State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi Province, 710032, China. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi Province, 710032, China. dujjm@163.com. .
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12: Title: Analysis of lncRNAs expression in UVB-induced stress responses of melanocytes.
Authors: Zeng, Qinghai, et.al. .
Journal: Journal of dermatological science (J Dermatol Sci), Vol. 81 (1): 53-60, 2016 .
Snippet: NAC reduced UVB-induced ROS generation and inhibited UVB-induced upregulation of lnc-GKN2-1:1 and lnc-CD1D-2:1.
Affiliation: Department of Plastic and Reconstructive Surgery, Third Xiangya Hospital of Central South University, Changsha 410013, China. Department of Oncology, Third Xiangya Hospital of Central South University, Changsha 410013, China. Department of Dermatology, Xiangya Hospital of Central South University, Changsha 410013, China. State Key Laboratory of Medical Genetics, Central South University, Changsha 410078, China. Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. Department of Oncoplastic and Reconstructive Surgery, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha 410013, China. School of Pharmaceutical sciences of Central South University, Changsha 410013, China. Key Laboratory of Genetics and Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha 410126, China. Central Laboratory, Third Xiangya Hospital of Central South University, Changsha 410013, China. Department of Oncology, Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address: caokehui168@aliyun.com. Department of Plastic and Reconstructive Surgery, Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address: doctorzhoujianda@163.com. .
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13: Title: Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2.
Authors: Fahlbusch, Fabian B, et.al. .
Journal: Histochemistry and cell biology (Histochem Cell Biol), Vol. 144 (3): 281-91, 2015 .
Snippet: GKN2 co-localized with smooth muscle actin in villous myofibroblasts and with HLA-G and GKN1 in EVT.
Affiliation: Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany, Fabian.Fahlbusch@uk-erlangen.de. .
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14: Title: Gastrokine-2 is transiently expressed in the endodermal and endothelial cells of the maturing mouse yolk sac.
Authors: Antas, Veronica I, et.al. .
Journal: Gene expression patterns : GEP (Gene Expr Patterns), Vol. 16 (2): 69-74, 2014 .
Snippet: We have therefore identified expression of Gkn2 transcript and protein in the visceral endodermal layer and at lower levels in YS endothelial cells.
Affiliation: Discipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, Australia. Discipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, Australia; Discipline of Anatomy & Histology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, Australia. Electronic address: stuart.fraser@sydney.edu.au. .
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15: Title: Effects of gastrokine‑2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways.
Authors: Shi, Lin-Sen, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 10 (6): 2898-904, 2014 .
Snippet: A total of 76 gastric cancer tissues with corresponding normal mucosae samples, and two gastric cancer cell lines (SGC‑7901 and AGS) were subjected to western blot analysis of gastrokine‑2 expression.
Affiliation: Department of Gastrointestinal Surgery, The Drum Tower Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China. .
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16: Title: [Expression and clinical significance of gastric dramatic down-related gene in gastric cancer and precancerous lesions].
Authors: Zhao, Zhanwei, et.al. .
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi), Vol. 30 (3): 306-8, 2014 .
Snippet: METHODS: Immunohistochemical staining was performed to detect the expression of GDDR in 240 cases of gastric tissues, including 40 cases of normal gastric mucosa (NGM), 40 cases of chronic superficial gastritis (CSG), 40 cases of chronic atrophic gastritis (CAG), 40 cases of intestinal metaplasia (IM), 20 cases of mild dysplasia (MD), 20 cases of severe dysplasia (SD) and 40 cases of gastric cancer (GC).
Affiliation: Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China. .
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17: Title: EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells.
Authors: Lu, Fang, et.al. .
Journal: Virology journal (Virol J), Vol. 11, 2014 .
Snippet: CONCLUSIONS: These findings demonstrate that EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes in GC cells, and suggest that EBNA1 contributes to the complex transcriptional and epigenetic deregulation of the GKN1 and GKN2 tumor suppressor genes in EBV positive GC.
Affiliation: The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Lieberman@wistar.org. .
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18: Title: Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis.
Authors: Dai, Jin, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 35 (5): 4199-207, 2014 .
Snippet: We found that GKN2 expression was significantly downregulated or absent in gastric cancer cell lines, gastric intestinal metaplasia, and tumor tissues.
Affiliation: Department of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan II Road, Guangzhou, Guangdong, 510080, People's Republic of China, 67358976@qq.com. .
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19: Title: GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.
Authors: Kim, Olga, et.al. .
Journal: Journal of cellular physiology (J Cell Physiol), Vol. 229 (6): 762-71, 2014 .
Snippet: We analyzed cell viability, proliferation, and death in AGS cells transfected with GKN1, GKN2, GKN1 plus GKN2 using MTT, BrdU incorporation, and apoptosis assays, respectively.
Affiliation: Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea. .
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20: Title: Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3.
Authors: Geahlen, Jessica H, et.al. .
Journal: Physiological genomics (Physiol Genomics), Vol. 45 (15): 667-83, 2013 .
Snippet: Haplotype analysis revealed that GKN3 mimics GKN2 in patterns of exonic SNP allocation, whereas GKN1 appeared to be more stringently selected.
Affiliation: Division of Gastroenterology, Department of Medicine, School of Medicine, Washington University, St. Louis, Missouri 63110, USA. .
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