refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
10 documents found
1: Title: The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity.
Authors: Gosavi, Prajakta, et.al. .
Journal: Journal of cell science (J Cell Sci), 2017 .
Snippet: Loss of Golgi ribbons in stable cells overexpressing GCC88 resulted in compromised mechanistic target of rapamycin (mTOR) signaling and a dramatic increase in LC3-II-positive autophagosomes, whereas RNAi depletion of GCC88 restored a Golgi ribbon and reduced autophagy.
Affiliation: The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia. Biological Optical Microscopy Platform, The University of Melbourne, Victoria 3010, Australia. Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia. The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia pgleeson@unimelb.edu.au. .
Related Products: order online
2: Title: Membrane trafficking. The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins.
Authors: Wong, Mie, et.al. .
Journal: Science (New York, N.Y.) (Science), Vol. 346 (6209): 1256898, 2014 .
Snippet: These findings demonstrate that golgins act as tethers in vivo, and hence the specificity we find to be encoded in this tethering is likely to make a major contribution to the organization of membrane traffic at the Golgi apparatus.
Affiliation: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. sean@mrc-lmb.cam.ac.uk. .
Related Products: order online
3: Title: Genome-wide association study of medication adherence in chronic diseases in the korean population.
Authors: Seo, Incheol, et.al. .
Journal: Genomics & informatics (Genomics Inform), Vol. 12 (3): 121-6, 2014 .
Snippet: The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, p = 4.87 × 10(-7)), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers.
Affiliation: Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea. .
Related Products: order online
4: Title: Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Authors: Cho, Yoon Shin, et.al. .
Journal: Nature genetics (Nat Genet), Vol. 44 (1): 67-72, 2012 .
Snippet: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3.
Affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Cheongwon-gun, Gangoe-myeon, Yeonje-ri, Korea. yooncho33@korea.kr .
Related Products: order online
5: Title: The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network.
Authors: Lieu, Zi Zhao, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 18 (12): 4979-91, 2007 .
Snippet: Depletion of GCC88 in HeLa cells by interference RNA resulted in a block in plasma membrane-TGN recycling of two cargo proteins, TGN38 and a CD8 mannose-6-phosphate receptor cytoplasmic tail fusion protein.
Affiliation: The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia. .
Related Products: order online
6: Title: Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse.
Authors: Lehrmann, Elin, et.al. .
Journal: PloS one, Vol. 1, 2006 .
Snippet: Common transcriptional changes were demonstrated for a majority of drug abuse cases (N = 34), representing a number of consistently changed functional classes: Calmodulin-related transcripts (CALM1, CALM2, CAMK2B) were decreased, while transcripts related to cholesterol biosynthesis and trafficking (FDFT1, APOL2, SCARB1), and Golgi/endoplasmic reticulum (ER) functions (SEMA3B, GCC1) were all increased.
Affiliation: Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America. elehrman@intra.nida.nih.gov .
Related Products: order online
7: Title: Interaction of Arl1 GTPase with the GRIP domain of Golgin-245 as assessed by GST (glutathione-S-transferase) pull-down experiments.
Authors: Lu, Lei, et.al. .
Journal: Methods in enzymology (Method Enzymol), Vol. 404, 2005 .
Snippet: GST-Arl1(GTP) can recover endogenous Golgin-245 from HeLa cell cytosol.
Affiliation: Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore. .
Related Products: order online
8: Title: The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
Authors: Luke, Michael R, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 388 (Pt 3): 835-41, 2005 .
Snippet: Four mammalian GRIP domain proteins have been identified which are targeted to the TGN through their GRIP domains, namely p230, golgin-97, GCC88 and GCC185.
Affiliation: The Russell Grimwade School of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia. .
Related Products: order online
9: Title: Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN.
Authors: Derby, Merran C, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 117 (Pt 24): 5865-74, 2004 .
Snippet: The four mammalian golgins, p230/golgin-245, golgin-97, GCC88 and GCC185 are targeted to trans-Golgi network (TGN) membranes by their C-terminal GRIP domain in a G-protein-dependent process.
Affiliation: The Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria 3010, Australia. .
Related Products: order online
10: Title: GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.
Authors: Luke, Michael R, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 278 (6): 4216-26, 2003 .
Snippet: By immunofluorescence and immunoelectron microscopy GCC88 and GCC185, and the GRIP protein golgin97, are all localized to the TGN of HeLa cells.
Affiliation: Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Victoria 3010, Australia. .
Related Products: order online
Documents per page: 20 | 50 | 100