refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
77 documents found
1: Title: Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein.
Authors: Chamberlin, Adam, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), 2019 .
Snippet: These mutations increase binding of the RHOA, MAP3K4 and FRAT1 proteins and generally decrease the binding of RAC1.
Affiliation: Ambry Genetics, Aliso Viejo, CA 92656, USA. Tempus Labs, Chicago, Illinois 60654, USA. Division of Endocrinology, Hormone and Molecular Genetics Laboratory (LIM/42), Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Pediatric Endocrinology, Marshfield Clinic, Marshfield, WI 54449, USA. .
Related Products: order online
2: Title: Association of Methylation Signatures at Hepatocellular Carcinoma Pathway Genes with Adiposity and Insulin Resistance Phenotypes.
Authors: Ramos-Lopez, Omar, et.al. .
Journal: Nutrition and cancer (Nutr Cancer), 2018 .
Snippet: These genes encompassed GADD45A, MTOR, FRAT2, E2F3, WNT7B, FRAT1, LRP5, DPF3, GSTA2, APC, MYC, WNT10B, ARID1B, AKT1, GSTA1, WNT5A, CDK4, GAB1, TCF7, which statistically contributed to the regulation of the HCC pathway (P = 2.10e-07).
Affiliation: a Department of Nutrition, Food Science and Physiology, and Center for Nutrition Research , University of Navarra , Pamplona , Spain. b Navarra Institute for Health Research (IdiSNA) , Pamplona , Spain. c CIBERobn, Fisiopatología de la Obesidad y la Nutrición, Carlos III Health Institute , Madrid , Spain. d Madrid Institute of Advanced Studies (IMDEA Food) , Madrid , Spain. .
Related Products: order online
3: Title: MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2.
Authors: Werner, Tamara V, et.al. .
Journal: Aging, Vol. 9 (3): 932-954, 2017 .
Snippet: Meningiomas are mostly benign, slow growing tumors of the central nervous system with a small percentage showing a malignant phenotype.Following in silico prediction of potential targets of miR-34a-3p, SMAD4, FRAT1, and BCL2 have been confirmed as targets by dual luciferase assays with co-expression of miR-34a-3p and reporter gene constructs containing the respective 3'UTRs.
Affiliation: Institute of Human Genetics, Medical School, Saarland University, 66421 Homburg/Saar, Germany. Institute for Clinical and Experimental Surgery, Medical School, Saarland University, 66421 Homburg/Saar, Germany. Institute of Pathology, Medical Center, Saarland University, 66421 Homburg/Saar, Germany. Clinical Bioinformatics, Saarland University, 66123 Saarbruecken, Germany. .
Related Products: order online
4: Title: FRAT1 expression regulates proliferation in colon cancer cells.
Authors: Zhu, Kongxi, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 12 (6): 4761-4766, 2016 .
Snippet: In this study, the expression of frequently rearranged in advanced T-cell lymphomas 1 (FRAT1) in colon cancer was investigated and the association between FRAT1 expression and biological properties of tumors was analyzed.
Affiliation: Department of Digestive Disease, The Second Hospital of Shandong University, Jinan, Shandong 250000, P.R. China. .
Related Products: order online
5: Title: Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells.
Authors: Fan, Wan-Hu, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 36 (5): 2999-3004, 2016 .
Snippet: Frequently rearranged in advanced T-cell lymphomas-1 (FRAT1) is a positive regulator of the Wnt/β-catenin signaling pathway and is overexpressed in many human tumors.
Affiliation: Department of Infectious Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China. .
Related Products: order online
6: Title: Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer.
Authors: Zhang, Wei, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 14 (4): 3551-8, 2016 .
Snippet: These results suggest that FRAT1 demonstrates oncogenic properties in prostate cancer, potentially by suppressing the inhibitory effect of nuclear glycogen synthase 3β against β‑catenin/TCF activity, thus activating the Wnt/β‑catenin signaling pathway and promoting cell growth.
Affiliation: Department of Urology, The Central Hospital of Wuhan, Wuhan, Hubei 430014, P.R. China. Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China. Department of Pathology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China. Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, P.R. China. .
Related Products: order online
7: Title: Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex.
Authors: Uzdensky, Anatoly, et.al. .
Journal: Molecular neurobiology (Mol Neurobiol), Vol. 54 (6): 4172-4188, 2017 .
Snippet: Diverse cellular subsystems were involved in the penumbra tissue response: signal transduction pathways such as protein kinase Bα/GSK-3, protein kinase C and its β1 and β2 isoforms, Wnt/β-catenin (axin1, GSK-3, FRAT1), Notch/NUMB, DYRK1A, TDP43; mitochondria quality control (Pink1, parkin, HtrA2); ubiquitin-mediated proteolysis (ubiquilin-1, UCHL1); axon outgrowth and guidance (NAV-3, CRMP2, PKCβ2); vesicular trafficking (syntaxin-8, TMP21, Munc-18-3, synip, ALS2, VILIP1, syntaxin, synaptophysin, synaptotagmin); biosynthesis of neuromediators (tryptophan hydroxylase, monoamine oxidase B, glutamate decarboxylase, tyrosine hydroxylase, DOPA decarboxylase, dopamine transporter); intercellular interactions (N-cadherin, PMP22); cytoskeleton (neurofilament 68, neurofilament-M, doublecortin); and other proteins (LRP1, prion protein, β-amyloid).
Affiliation: Laboratory of Molecular Neurobiology, Academy of Biology and Biotechnology, Southern Federal University, 194/1 Stachky pr., Rostov-on-Don, 344090, Russia. auzd@yandex.ru. Laboratory of Molecular Neurobiology, Academy of Biology and Biotechnology, Southern Federal University, 194/1 Stachky pr., Rostov-on-Don, 344090, Russia. Institute of Arid Zones, Southern Scientific Center of Russian Academy of Sciences, 41 Chekhov prosp., Rostov-on-Don, 344006, Russia. Regional Consulting and Diagnostic Center, 127 Pushkinskaya st., Rostov-on-Don, 344010, Russia. .
Related Products: order online
8: Title: Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway.
Authors: Zheng, Kehong, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 376 (1): 178-87, 2016 .
Snippet: The frequently rearranged in advanced T-cell lymphomas (FRAT1) protein was identified as a direct target of miR-490-3p and contributes to its tumor-suppressing effects.
Affiliation: Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Department of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China. Radiotherapy Department, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China. Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: drhuangzh@163.com. Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Electronic address: liangsmu@foxmail.com. .
Related Products: order online
9: Title: Silencing of FRAT1 by siRNA inhibits the proliferation of SGC7901 human gastric adenocarcinoma cells.
Authors: Yu, Qinggong, et.al. .
Journal: Biomedical reports (Biomed Rep), Vol. 4 (2): 223-226, 2016 .
Snippet: Frequently rearranged in advanced T cell lymphomas-1 (FRAT1) positively regulates the Wnt/β-catenin signaling pathway by inhibiting glycogen synthase kinase-3 mediated phosphorylation of β-catenin.
Affiliation: Department of Gastroenterology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China. Department of Infectious Diseases, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China. .
Related Products: order online
10: Title: Comparative two-dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder.
Journal: Journal of cellular and molecular medicine (J Cell Mol Med), Vol. 19 (11): 2664-78, 2015 .
Snippet: Increased expression of proto-oncogene Frequently rearranged in advanced T-cell lymphomas 1 (FRAT1), Kinesin family member 14, Integrin alpha6 subunit, growth hormone regulated TBC protein 1, parotid secretory protein, Prolactin-inducible protein precursor, Mucin-16, Ca binding protein migration inhibitory factor-related protein 14 (MRP14) was observed in individuals with ASD.
Affiliation: Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY, USA. SUNY Plattsburgh Neuropsychology Clinic and Psychoeducation Services, Plattsburgh, NY, USA. Department of Psychology, SUNY Plattsburgh, Plattsburgh, NY, USA. .
Related Products: order online
11: Title: The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.
Authors: Yuan, Yuan, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 36 (12): 9961-8, 2015 .
Snippet: The percentage of cases with positive FRAT1 and ABCG2 overexpression was significantly higher in PDAC patients with poor differentiation, lymph node metastasis, invasion, and TNM stage III/IV disease than in patients with well-differentiated tumor, no lymph node metastasis and invasion, and TNM stage I/II disease (P < 0.05 or P < 0.01).
Affiliation: Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, People's Republic of China. Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, 410011, Hunan, People's Republic of China. zhulinyang@yahoo.com. Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, 410011, Hunan, People's Republic of China. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China. .
Related Products: order online
12: Title: Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells for Inhibiting Myofibroblastic Differentiation of Irradiated Human Lung Fibroblasts.
Authors: Zhang, Chunyang, et.al. .
Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med), Vol. 236 (3): 209-17, 2015 .
Snippet: Co-culture with HUMSCs decreased FRAT1 protein levels in irradiated nHLFs.
Affiliation: Respiratory Department, Navy General Hospital. .
Related Products: order online
13: Title: [Effect of irradiated human lung fibroblasts on activation of canonical Wnt/β-catenin signaling pathway in mesenchymal stem cells].
Authors: Zhang, Chun-yang, et.al. .
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences (Zhejiang Da Xue Xue Bao Yi Xue Ban), Vol. 44 (2): 162-6, 2015 .
Snippet: The protein levels of GSK-3β, p-GSK-3β, FRAT1 and β-catenin in HUMSCs were examined by Western blotting 3 days after culture or co-culture.
Affiliation: 1.Graduate Student Team of Medical School of Chinese PLA, Beijing 100853, China;2.Department of Respiratory Medicine, Navy General Hospital, Beijing 100048, China; Department of Respiratory Medicine, Navy General Hospital, Beijing 100048, China; .
Related Products: order online
14: Title: Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.
Authors: Guo, Geng, et.al. .
Journal: Disease markers (Dis Markers), Vol. 2015, 2015 .
Snippet: FRAT1 is a positive regulator of the Wnt/β-catenin signaling pathway and is overexpressed in many human tumors.
Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China. GCP Center, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300192, China ; Postdoctoral Programme, China Academy of Chinese Medical Sciences, Beijing 100700, China. Department of Neurosurgery, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Shanxi Medical University, Taiyuan, Shanxi 030001, China. Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China. Department of Neurology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. .
Related Products: order online
15: Title: The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.
Authors: He, L, et.al. .
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (Clin Transl Oncol), Vol. 17 (6): 438-45, 2015 .
Snippet: METHODS: ROR2 and FRAT1 protein expression in tissues was measured by immunohistochemistry. RESULTS: The percentage of positive ROR2 and FRAT1 expression was significantly higher in patients with chondrosarcoma than in patients with osteochondroma (P < 0.01).
Affiliation: Department of Orthopedics, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, 410011, Hunan, China. .
Related Products: order online
16: Title: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.
Authors: Jin, Runsen, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 127 (Pt 14): 3116-30, 2014 .
Snippet: The mechanism of inhibiting β-catenin phosphorylation involves the NDRG1-mediated upregulation of the GSK3β-binding protein FRAT1, which prevents the association of GSK3β with the Axin1-APC-CK1 destruction complex and the subsequent phosphorylation of β-catenin.
Affiliation: Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, NSW 2006, Australia. Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, NSW 2006, Australia. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China Department of General Surgery, Shanghai Minhang District Central Hospital (Minhang District Central Hospital of Shanghai Ruijin Hospital Group), Shanghai 201100, P.R. China zmhtiger@yeah.net d.richardson@med.usyd.edu.au zaklina.kovacevic@sydney.edu.au. Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, NSW 2006, Australia zmhtiger@yeah.net d.richardson@med.usyd.edu.au zaklina.kovacevic@sydney.edu.au. .
Related Products: order online
17: Title: WNT1 gene expression alters in heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+ prostate cancer stem cell spheroids.
Authors: Goksel, Gamze, et.al. .
Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J Buon), Vol. 19 (1): 207-14, 2014 Jan-Mar .
Snippet: The expression levels of WNT1, FZD1, ADAR, APC, AXIN, BTRC, FRAT1 and PPARD genes were measured by polymerase chain reaction (PCR) array assay and the protein expression levels of WNT1, FZD and AXIN by immunohistochemistry. RESULTS: The expression levels of WNT pathway-related molecules were found to increase in both CSCs and non- CSCs when CSCs were maintained as spheroids.
Affiliation: Celal Bayar University Faculty of Medicine, Department of Medical Oncology, Manisa, Turkey. .
Related Products: order online
18: Title: Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/β-catenin signaling.
Authors: Loke, Johnny, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 23 (4): 1073-83, 2014 .
Snippet: In transformed B-lymphoblastoid cell lines and NT2/D1 cells transfected with wild-type or mutant MAP3K1 cDNAs under control of the constitutive CMV promoter, these mutations increased binding of RHOA, MAP3K4, FRAT1 and AXIN1 and increased phosphorylation of p38 and ERK1/2.
Affiliation: Department of Pathology and. .
Related Products: order online
19: Title: Classifying chemical mode of action using gene networks and machine learning: a case study with the herbicide linuron.
Authors: Ornostay, Anna, et.al. .
Journal: Comparative biochemistry and physiology. Part D, Genomics & proteomics (Comp Biochem Physiol Part D Genomics Proteomics), Vol. 8 (4): 263-74, 2013 .
Snippet: To improve understanding of androgen receptor signaling in the ovary, a reciprocal gene expression network was constructed for DHT and FLUT using pathway analysis and these data suggested that steroid metabolism, translation, and DNA replication are processes regulated through AR signaling in the ovary.
Affiliation: Department of Biology and Canadian Rivers Institute, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, Canada. .
Related Products: order online
20: Title: Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion.
Authors: Guo, Geng, et.al. .
Journal: PloS one, Vol. 8 (4): e61206, 2013 .
Snippet: BACKGROUND: FRAT1 positively regulates the Wnt/β-catenin signaling pathway by inhibiting GSK-3-mediated phosphorylation of β-catenin.
Affiliation: Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China. .
Related Products: order online
Page 1 2 3 4 
Documents per page: 20 | 50 | 100