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23 documents found
1: Title: Exploring lncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment: Advances and Challenges.
Authors: Dong, Peixin, et.al. .
Journal: Cancers (Cancers (basel)), Vol. 11 (2), 2019 .
Snippet: Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-RoR) have been identified as upstream modulators or downstream effectors of major signaling pathways influencing EC metastasis, including the PTEN/PI3K/AKT/mTOR, RAS/RAF/MEK/ERK, WNT/β-catenin and p53 signaling pathways.
Affiliation: Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. dpx1cn@gmail.com. Department of Gynecology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. tdken999@163.com. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA. jyue@uthsc.edu. Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA. jyue@uthsc.edu. Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. sjbh1810@mta.biglobe.ne.jp. Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. norikingyo@med.hokudai.ac.jp. Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Sapporo 003-0804, Japan. yukiharu@sap-cc.go.jp. Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. watarih@med.hokudai.ac.jp. .
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2: Title: Overexpression of LncRNA FER1L4 in endometrial carcinoma is associated with favorable survival outcome.
Authors: Kong, Y, et.al. .
Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci), Vol. 22 (23): 8113-8118, 2018 .
Snippet: OBJECTIVE: Long noncoding RNA Fer-1-like protein 4 (FER1L4) is a novel cancer-related lncRNA and functions as a tumor suppressor in several cancers.
Affiliation: Department of Oncology, Dalian Third People's Hospital, Dalian, Liaoning, China. zzmnb7791@163.com. .
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3: Title: Long Noncoding RNA FER1L4 Suppresses Tumorigenesis by Regulating the Expression of PTEN Targeting miR-18a-5p in Osteosarcoma.
Authors: Fei, Dan, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 51 (3): 1364-1375, 2018 .
Snippet: BACKGROUND/AIMS: Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been reported to play crucial regulatory roles in tumor progression.
Affiliation: Department of Ultrasonographic, China-Japan Union Hospital of Jilin University, Changchun, China. Department of Anesthesiology, the First Hospital of Jilin University, Changchun, China. Department of Pediatrics, the First Hospital of Jilin University, Changchun, China. Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Chinazhaodongxu909@sina.com. Department of Neurosurgery, the First Hospital of Jilin University, Changchun, China. .
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4: Title: Overexpression of the lncRNA FER1L4 inhibits paclitaxel tolerance of ovarian cancer cells via the regulation of the MAPK signaling pathway.
Authors: Liu, Siwei, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), 2018 .
Snippet: To reveal the molecular mechanism, we measured the relative protein phosphorylation level of ERK and MAPK in SKOV3, SKOV3-PR, SKOV3-PR/pcDNA3.1, and SKOV3-PR/pcDNA3.1-FER1L4
Affiliation: Department of Obstetrics & Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. .
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5: Title: Long non‑coding RNA Fer‑1‑like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo.
Authors: Sun, Xinyi, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 19 (1): 685-692, 2019 .
Snippet: The aim of the present study was to investigate the potential role of long non‑coding RNA Fer‑1‑like family member 4 (FER1L4) in the proliferation of hepatocellular carcinoma (HCC) through the regulation of phosphatase and tensin homolog (PTEN) expression.
Affiliation: Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China. .
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6: Title: Upregulation of lncRNA FER1L4 suppresses the proliferation and migration of the hepatocellular carcinoma via regulating PI3K/AKT signal pathway.
Authors: Wang, Xu, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), Vol. 120 (4): 6781-6788, 2019 .
Snippet: Moreover, the effect of FER1L4 on PI3K/AKT signal pathway activation was investigated through analyzing phosphorylation of related proteins, p-AKT/AKT and p-PI3K/PI3K, via Western blot assay.
Affiliation: Department of No.2 Ward of Hepatobiliary Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. Department of Echocardiography and Noninvasive Cardiology Laboratory, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China. .
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7: Title: The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force.
Authors: Huang, Yiping, et.al. .
Journal: European journal of orthodontics (Eur J Orthod), 2018 .
Snippet: The levels of eight lncRNAs of interest (FER1L4, HIF1A-AS2, MIAT, NEAT1, ADAMTS9-AS2, LUCAT1, MIR31HG, and DHFRP1) were measured via qRT-PCR, and the results were found to be consistent with those of RNA sequencing.
Affiliation: Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing. Department of Stomatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing. National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University, Beijing, China. .
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8: Title: LncRNA FER1L4 suppressed cancer cell growth and invasion in esophageal squamous cell carcinoma.
Authors: Ma, W, et.al. .
Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci), Vol. 22 (9): 2638-2645, 2018 .
Snippet: Overexpression of FER1L4 could inhibit cell proliferation and invasion, promote apoptosis and increase the cell cycle distribution in G0/G1 phase.
Affiliation: Department of Radiotherapy, Gansu Province Hospital, Lanzhou, China. 13893212070@126.com. .
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9: Title: Low-expression of lncRNA FER1L4 might be a prognostic marker in osteosarcoma.
Authors: Chen, Z-X, et.al. .
Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci), Vol. 22 (8): 2310-2314, 2018 .
Snippet: OBJECTIVE: To investigate the potential role of Long non-coding RNA (lncRNA) FER1L4 in the diagnosis and prognostic assessment of osteosarcoma.
Affiliation: Department of Orthopedics, Yidu Central Hospital of Weifang, Qingzhou, China. yishengkeyan@163.com. .
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10: Title: Long non-coding RNA Fer-1-like family member 4 is overexpressed in human glioblastoma and regulates the tumorigenicity of glioma cells.
Authors: Ding, Feng, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 14 (2): 2379-2384, 2017 .
Snippet: A short interfering (si)RNA targeting FER1L4 was transfected into U373-MG and U251 glioma cell lines, and cell viability, invasion and apoptosis were examined using CCK-8, Transwell and Annexin V-fluorescein isothiocyanate/propidium iodide assays, respectively.
Affiliation: Department of General Surgery, Jinan Hospital, Jinan, Shandong 250000, P.R. China. Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan, Hubei 430000, P.R. China. Department of Neurosurgery, Yancheng First Peoples' Hospital, Yancheng, Jiangsu 224001, P.R. China. Department of Neurosurgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China. .
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11: Title: Long non-coding RNA Fer-1-like protein 4 acts as a tumor suppressor via miR-106a-5p and predicts good prognosis in hepatocellular carcinoma.
Authors: Wu, Ju, et.al. .
Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark), Vol. 20 (1): 55-65, 2017 .
Snippet: FER1L4, as well as miR-106a-5p, can predict the clinical prognosis of HCC alone or combined, which may be a novel therapeutic target for treating HCC.
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12: Title: A novel Bxb1 integrase RMCE system for high fidelity site-specific integration of mAb expression cassette in CHO Cells.
Authors: Inniss, Mara C, et.al. .
Journal: Biotechnology and bioengineering (Biotechnol Bioeng), Vol. 114 (8): 1837-1846, 2017 .
Snippet: We first integrated a DNA construct flanked by either Bxb1 attachment sites or FRT sequences (referred to as a landing pad) into the Fer1L4 genomic locus of CHO-S cells using CRISPR/Cas9 mediated homologous recombination.
Affiliation: Cell Line Development, Biotherapeutics Pharmaceutical Science, Pfizer Inc, Andover 01810, Massachusetts. Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts. .
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13: Title: LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma.
Authors: Qiao, Qiao, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 478 (2): 507-12, 2016 .
Snippet: Additionally, a significant decrease of cell proliferation was observed in FER1L4 overexpressing cells, along with cell cycle arrest at G0/G1 phase and increased proportion of apoptotic cells.
Affiliation: Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Department of Gynecology and Obstetrics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China. Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China. Electronic address: Lihong_GO@163.com. .
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14: Title: Roles of long noncoding RNAs in gastric cancer and their clinical applications.
Authors: Sun, Weiliang, et.al. .
Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol), Vol. 142 (11): 2231-7, 2016 .
Snippet: Several lncRNAs including HOTAIR, HULC, LINC00152, MALAT2, H19, GHET1, and GACAT3 have been demonstrated having oncogene activities, while other lncRNAs including LEIGC, GAS5, and FER1L4 have been thought as tumor suppressors.
Affiliation: Ningbo Yinzhou People's Hospital and the Affiliated Yinzhou Hospital, Ningbo University School of Medicine, 315040, Ningbo, China. Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, 315211, Ningbo, China. Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, 315211, Ningbo, China. guojunming@nbu.edu.cn. .
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15: Title: Expression profiles of differentially expressed genes affecting fecundity in goat ovarian tissues.
Authors: Ling, Y H, et.al. .
Journal: Genetics and molecular research : GMR (Genet Mol Res), Vol. 14 (4): 18743-52, 2015 .
Snippet: The FER1L4 gene showed the level of highest up-regulation in the multiparous library, while SRD5A2 expression showed the greatest down-regulation.
Affiliation: College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui, China. Local Animal Genetic Resources Conservation and Biobreeding Laboratory of Anhui Province, Hefei, Anhui, China. College of Economy and Technology, Anhui Agricultural University, Hefei, Anhui, China. Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Anhui, Beijing, China. .
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16: Title: Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins.
Authors: Redpath, Gregory M I, et.al. .
Journal: Traffic (Copenhagen, Denmark) (Traffic), Vol. 17 (3): 245-66, 2016 .
Snippet: Ferlins are a family of transmembrane-anchored vesicle fusion proteins uniquely characterized by 5-7 tandem cytoplasmic C2 domains, Ca(2+)-regulated phospholipid-binding domains that regulate vesicle fusion in the synaptotagmin family.
Affiliation: Institute for Neuroscience and Muscle Research, Kid's Research Institute, Children's Hospital at Westmead, Sydney, Australia. Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, Australia. Microbial Imaging Facility, The iThree Institute, University of Technology Sydney, Ultimo, Australia. .
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17: Title: Gene expression profiling of pre-eclamptic placentae by RNA sequencing.
Authors: Kaartokallio, Tea, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Some of the genes identified in our study have been reported by numerous microarray studies (BHLHE40, FSTL3, HK2, HTRA4, LEP, PVRL4, SASH1, SIGLEC6), but many have been implicated in only few studies or have not previously been linked to pre-eclampsia (ARMS2, BTNL9, CCSAP, DIO2, FER1L4, HPSE, LOC100129345, LYN, MYO7B, NCMAP, NDRG1, NRIP1, PLIN2, SBSPON, SERPINB9, SH3BP5, TET3, TPBG, ZNF175).
Affiliation: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, FI-00014, Finland. Research Programs Unit, Genome-Scale Biology and Institute of Biomedicine, University of Helsinki, Helsinki, FI-00014, Finland. Molecular Neurology Research Program, University of Helsinki, Helsinki, FI-00014, Finland. Folkhälsan Institute of Genetics, Helsinki, FI-000290, Finland. .
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18: Title: Long noncoding RNA FER1L4 suppresses cancer cell growth by acting as a competing endogenous RNA and regulating PTEN expression.
Authors: Xia, Tian, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Here, we report that the lncRNA FER1L4 (fer-1-like family member 4, pseudogene) acts as a competing endogenous RNA (ceRNA) to regulate the expression of PTEN (a well-known tumor suppressor gene) by taking up miR-106a-5p in gastric cancer.
Affiliation: Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, Zhejiang, 315211, China. .
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19: Title: Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer.
Authors: Yue, Ben, et.al. .
Journal: Cancer science (Cancer Sci), Vol. 106 (10): 1323-32, 2015 .
Snippet: Moreover, striking differences in overall survival and disease-free survival were observed for the cases with both low FER1L4 expression and high miR-106a-5p expression compared with cases with high FER1L4 expression and low miR-106a-5p expression.
Affiliation: Department of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China. Department of Pharmacy, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China. .
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20: Title: Long noncoding RNA associated-competing endogenous RNAs in gastric cancer.
Authors: Xia, Tian, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 4, 2014 .
Snippet: For instance, through its miRNA response elements (MREs) to compete for miR-106a-5p, lncRNA-FER1L4 regulates the expression of PTEN, RB1, RUNX1, VEGFA, CDKN1A, E2F1, HIPK3, IL-10, and PAK7.
Affiliation: 1] Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, Zhejiang, 315211, China [2]. Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, Zhejiang, 315211, China. .
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