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22 documents found
1: Title: Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma.
Authors: Wang, Kai, et.al. .
Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol), 2018 .
Snippet: PURPOSE: F-box proteins, as components of the Skp1-Cullin 1-F-box protein (SCF) E3 ubiquitin ligase, can specifically bind to substrates and regulate multiple tumor behaviors.
Affiliation: Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China. Department of Healthcare Respiratory, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China. Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China. dujiajun@sdu.edu.cn. Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China. dujiajun@sdu.edu.cn. .
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2: Title: Proteomic analysis of sperm proteins in infertile men with high levels of reactive oxygen species.
Authors: Ayaz, A, et.al. .
Journal: Andrologia, 2018 .
Snippet: Using computational studies, and data mining of available literature on spermatozoa, oxidative stress and proteomics, we identified three core regulatory proteins angiotensin-converting enzyme (ACE), heat-shock protein (Hsp70) family A member 2 (HSPA2) and ribosomal protein subunit 27A (RPS27A) and seven interlink proteins NOS2, SUMO2, UBL4A, FBXO25, MAP3K3, APP and UBC.
Affiliation: American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA. Department of Urology, Tulane Medical Center, New Orleans, LA, USA. .
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3: Title: Food restriction increase the expression of mTORC1 complex genes in the skeletal muscle of juvenile pacu (Piaractus mesopotamicus).
Journal: PloS one, Vol. 12 (5): e0177679, 2017 .
Snippet: There was an increase in the mRNA levels of catabolic pathways components (FBXO25, ATG12, BCL2) and energetic metabolism-related genes (PGC1α and SDHA), together with a decrease in PPARβ/δ mRNA levels.
Affiliation: Department of Morphology, Institute of Bioscience of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil. Aquaculture Center, São Paulo State University, Jaboticabal, São Paulo, Brazil. Department of Biostatistics, Institute of Bioscience of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil. São Paulo Agency for Agribusiness Technology, Presidente Prudente, São Paulo, Brazil. University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil. .
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4: Title: FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation.
Authors: Teixeira, Felipe R, et.al. .
Journal: Archives of biochemistry and biophysics (Arch Biochem Biophys), Vol. 621, 2017 .
Snippet: Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.
Affiliation: Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Brazil; Department of Genetics and Evolution, Federal University of Sao Carlos, Brazil. Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Brazil. Department of Biochemistry, Chemistry Institute, University of São Paulo, Brazil. Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Brazil. Electronic address: mdamario@fmrp.usp.br. .
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5: Title: FBXO25 promotes cell proliferation, invasion, and migration of NSCLC.
Authors: Jiang, Gui-Yang, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (10): 14311-14319, 2016 .
Snippet: Furthermore, we demonstrated that FBXO25 could regulate the expression of β-catenin, YAP, some cyclins, and matrix metalloproteinases (MMPs).
Affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China. Department of Pathology, Cancer Hospital of China Medical University, Shenyang, China. zhycmu@163.com. .
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6: Title: Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study.
Authors: Zhao, Min, et.al. .
Journal: BMC genomics, Vol. 17 Suppl 7, 2016 .
Snippet: Remarkably, seven TSGs displayed concordant CNL and gene down-regulation in at least 50 tumor samples: MTAP (212 samples), PTEN (139), MCPH1 (85), FBXO25 (67), SMAD4 (64), TRIM35 (57), and RB1 (54).
Affiliation: School of Engineering, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, QLD, 4558, Australia. Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA. zhongming.zhao@uth.tmc.edu. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA. zhongming.zhao@uth.tmc.edu. Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA. zhongming.zhao@uth.tmc.edu. Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA. zhongming.zhao@uth.tmc.edu. .
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7: Title: Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
Authors: Kraus, William E, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 11 (11): e1005553, 2015 .
Snippet: Our strongest findings were for SCDA metabolite levels with variants in genes that regulate components of endoplasmic reticulum (ER) stress (USP3, HERC1, STIM1, SEL1L, FBXO25, SUGT1) These findings were validated in a second cohort of CATHGEN subjects (N = 2022, combined p = 8.4x10-6-2.3x10-10).
Affiliation: Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, United States of America. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America. Division of Endocrinology, Department of Medicine, Duke University, Durham, North Carolina, United States of America. Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States of America. .
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8: Title: Prenatal Screening of 21 Microdeletion/Microduplication Syndromes and Subtelomeric Imbalances by MLPA in Fetuses with Increased Nuchal Translucency and Normal Karyotype.
Authors: Gouas, Laetitia, et.al. .
Journal: Cytogenetic and genome research (Cytogenet Genome Res), Vol. 146 (1): 28-32, 2015 .
Snippet: One sample showed a benign CNV (dup(8)pter, FBXO25 gene), and 1 patient was found to have a loss of 18 qter and a gain of 5 pter as a result of an unbalanced translocation.
Affiliation: Service de Cytogx00E9;nx00E9;tique Mx00E9;dicale, Unitx00E9; de Mx00E9;decine Fx0153;tale, CHU Clermont-Ferrand, Clermont-Ferrand, France. .
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9: Title: Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors.
Authors: Kang, Guhyun, et.al. .
Journal: Oncotarget, Vol. 7 (6): 6538-51, 2016 .
Snippet: We additionally identified three recurrent read-through fusion transcripts: POLA2-CDC42EP2, C8orf42-FBXO25, and STX16-NPEPL1.
Affiliation: Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. Bioinformatics Laboratory, Samsung SDS Co., Ltd., Seoul, Korea. Samsung Cancer Research Institute, Samsung Medical Center, Seoul, Korea. Center for Cancer Companion Diagnostics, Samsung Medical Center, Seoul, Korea. Current address: Department of Pathology, Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea. Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Samsung Genome Institute, Samsung Medical Center, Seoul, Korea. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. .
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10: Title: Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development.
Authors: Jeong, Hoe-Su, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1849 (6): 709-21, 2015 .
Snippet: We report that an Fbxo25-mediated SCF ubiquitination pathway regulates the protein levels and activities of Tbx5 and Nkx2-5 based on our studies using MG132, proteasome inhibitor, and the temperature sensitive ubiquitin system in ts20 cells.
Affiliation: Department of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea. Department of Developmental Biology, CHA University, Seoul 135-907, Republic of Korea. Major of Animal Science, College of Natural Science, Konkuk University, Chungju 380-701, Republic of Korea. Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 143-701, Republic of Korea. Center for Cancer Research, Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. College of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea. Department of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: chakimster@gmail.com. Department of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: ks66kim@hanyang.ac.kr. .
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11: Title: Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
Authors: Baumann, Ursula, et.al. .
Journal: Nature medicine (Nat Med), Vol. 20 (12): 1401-9, 2014 .
Snippet: FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex.
Affiliation: Department of Medicine III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. Institute of Pathology, Julius-Maximilians-University and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany. Department of Proteomics and Bioanalytics, Technische Universität München, Freising, Germany. 1] Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. [2] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. 1] Department of Gene Vectors, Helmholtz Center Munich-German Research Center for Environmental Health, Munich, Germany. [2] Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany. Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany. Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Bonn, Germany. Biotechnology Centre of Oslo, Oslo, Norway. Institute of Pathology, Hematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Kiel, Germany. Department of Medicine III, University Hospital Munchen, Munich, Germany. Translational Oncology, Department of Medicine A, Universitätsklinikum Münster, Münster, Germany. 1] Department of Medicine III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. [2] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. 1] Department of Proteomics and Bioanalytics, Technische Universität München, Freising, Germany. [2] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. [3] Center for Integrated Protein Science Munich (CIPSM), Freising, Germany. .
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12: Title: The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.
Authors: Teixeira, Felipe R, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (39): 28152-62, 2013 .
Snippet: FBXO25 is one of the 69 known human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of SKP1, Rbx1, Cullin1, and F-box protein (SCF1) that are involved in targeting proteins for degradation across the ubiquitin proteasome system.
Affiliation: From the Departments of Biochemistry and Immunology and. .
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13: Title: Effects of triploidy on growth and protein degradation in skeletal muscle during recovery from feed deprivation in juvenile rainbow trout (Oncorhynchus mykiss).
Authors: Cleveland, Beth M, et.al. .
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (Comp Biochem Physiol A Mol Integr Physiol), Vol. 166 (1): 128-37, 2013 .
Snippet: Reduced expression of ubiquitin ligases fbxo32 and fbxo25 and autophagy-related genes during refeeding implicates reduced proteolysis in recovery growth.
Affiliation: National Center for Cool and Cold Water Aquaculture, ARS/USDA, 11861 Leetown Rd, Kearneysville, WV 25427, USA. beth.cleveland@ars.usda.gov .
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14: Title: Effects of sex steroids on indices of protein turnover in rainbow trout (Oncorhynchusmykiss) white muscle.
Authors: Cleveland, Beth M, et.al. .
Journal: General and comparative endocrinology (Gen Comp Endocrinol), Vol. 174 (2): 132-42, 2011 .
Snippet: Single injections of E2 increased expression of ubiquitin ligase genes fbxo32, fbxo25, and murf1, and the proteasome subunit psmd6 by 24h after injection.
Affiliation: United States Department of Agriculture, Agricultural Research Service, National Center for Cool and Cold Water Aquaculture, 11861 Leetown Rd., Kearneysville, WV 25430, USA. beth.cleveland@ars.usda.gov .
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15: Title: Differential response of multiple zebrafish hepatic F-box protein genes to 17alpha-ethinylestradiol treatment.
Authors: Zheng, Hongping, et.al. .
Journal: Journal of environmental sciences (China) (J Environ Sci-china), Vol. 23 (4): 664-70, 2011 .
Snippet: Our results showed that EE2 exposure reduced the expression of fbxl14a, fbxl14b, fbxo25 and beta-TRCP2b, but enchanced the expression of skp2.
Affiliation: Shanghai Key Laboratory for MolecularAndrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. .
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16: Title: A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
Authors: Jang, Jae-Woo, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 410 (2): 183-8, 2011 .
Snippet: Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
Affiliation: Stem Cell Research Laboratory, Department of Developmental Biology, CHA University, Seoul 135-907, Republic of Korea. .
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17: Title: Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar): sequence analysis, genomic structure and modulation of expression.
Authors: Tacchi, Luca, et.al. .
Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (Comp Biochem Physiol B Biochem Mol Biol), Vol. 157 (4): 364-73, 2010 .
Snippet: The phylogenetic relationship between atrogin-1 and two other closely related ubiquitin E3 ligases FBXO25 and MuRF1 showed atrogin-1 and FBXO25 grouped together with MuRF1 being more distant.
Affiliation: Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK. .
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18: Title: Molecular characterization of atrogin-1/F-box protein-32 (FBXO32) and F-box protein-25 (FBXO25) in rainbow trout (Oncorhynchus mykiss): Expression across tissues in response to feed deprivation.
Authors: Cleveland, Beth M, et.al. .
Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (Comp Biochem Physiol B Biochem Mol Biol), Vol. 157 (3): 248-57, 2010 .
Snippet: In rainbow trout, the cDNA sequences of two E3 ubiquitin ligase F-box proteins, FBXO32 and FBXO25, were characterized and their expression across tissues in response to feed deprivation was determined.
Affiliation: USDA-ARS, National Center for Cool and Cold Water Aquaculture, 11861 Leetown Rd, Kearneysville, WV 25430, USA. beth.cleveland@ars.usda.gov .
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19: Title: Identification of FBXO25-interacting proteins using an integrated proteomics approach.
Authors: Teixeira, Felipe R, et.al. .
Journal: Proteomics, Vol. 10 (15): 2746-57, 2010 .
Snippet: FBXO25 is one of the 68 human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of s-phase-kinase associated protein 1, really interesting new gene-box 1, Cullin 1, and F-box protein (SCF1) that are involved in targeting proteins for destruction across the ubiquitin proteasome system.
Affiliation: Department of Biochemistry and Immunology, University of São Paulo, Ribeirão Preto, Brazil. .
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20: Title: FBXO25-associated nuclear domains: a novel subnuclear structure.
Authors: Manfiolli, Adriana O, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 19 (5): 1848-61, 2008 .
Snippet: Also, we present evidences that an FBXO25-dependent ubiquitin ligase activity prevents aggregation of recombinant polyglutamine-containing huntingtin protein in the nucleus of human embryonic kidney 293 cells, suggesting that this protein can be a target for the nuclear FBXO25 mediated ubiquitination.
Affiliation: Departments of Biochemistry and Immunology and Cellular and Molecular Biology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil. .
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