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16 documents found
1: Title: A novel gene (FAM20B encoding glycosaminoglycan xylosylkinase) for neonatal short limb dysplasia resembling Desbuquois dysplasia.
Authors: Kuroda, Yukiko, et.al. .
Journal: Clinical genetics (Clin Genet), 2019 .
Snippet: Given the fact that FAM20B deficiency causes skeletal phenotypes in mice and zebrafish, these variants are highly likely to be pathogenic.
Affiliation: Division of Medical Genetics, Kanagawa Children's Medical Center, Yokohama, Japan. Clinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Japan. Department of Clinical Genetics, Tokai University Hospital, Isehara, Kanagawa, Japan. Department of Obstetrics and Gynecology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. Center for Intractable Diseases, Saitama Medical University Hospital, Saitama, Japan. .
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2: Title: Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects.
Authors: Liu, Xuena, et.al. .
Journal: European journal of oral sciences (Eur J Oral Sci), Vol. 126 (5): 433-436, 2018 .
Snippet: In this study, by mating Wnt1-cre mice with Fam20b-floxed mice (Fam20bflox/flox), we created Wnt1-Cre;Fam20bflox/flox mice in which Fam20b is ablated in the neural crest-derived mesenchyme.
Affiliation: Department of Radiology, The 2nd Hospital Affiliated to Dalian Medical University, Dalian, Liaoning, China. Department of Oral Pathology, College of Stomatology, Dalian Medical University, Dalian, Liaoning, China. Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX, USA. .
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3: Title: Structure and evolution of the Fam20 kinases.
Authors: Zhang, Hui, et.al. .
Journal: Nature communications (Nat Commun), Vol. 9 (1): 1218, 2018 .
Snippet: Fam20B phosphorylates a xylose residue to regulate proteoglycan synthesis.
Affiliation: The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China. Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China. Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA. Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38015, USA. The Life Sciences Institute, Zhejiang University, 310058, Hangzhou, China. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China. junyuxiao@pku.edu.cn. .
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4: Title: Methods to Purify and Assay Secretory Pathway Kinases.
Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol), Vol. 1496, 2016 .
Snippet: Here, we describe methods to purify and assay two members of the four-jointed family of secretory kinases: the Fam20C protein kinase and the Fam20B proteoglycan kinase.
Affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX, 75390-9148, USA. vincent.tagliabracci@utsouthwestern.edu. Discovery Bioanalytics, Merck and Co, Rahway, NJ, USA. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China. junyuxiao@pku.edu.cn. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. junyuxiao@pku.edu.cn. .
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5: Title: Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects.
Authors: Ma, Pan, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: In particular, we demonstrated that the WNT inhibitor was able to rescue part of the bone defects in Osr2-Cre;Fam20B(fl/fl) mice, indicating that FAM20B-catalyzed proteoglycans regulate postnatal endochondral ossification partially through the mediation of WNT signaling.
Affiliation: Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University Baylor College of Dentistry, Dallas, Texas, United States of America. Department of Oral Implantology, Beijing Stomatological Hospital, Capital Medical University, Beijing, People's Republic of China. Department of Diagnostic Sciences, Texas A&M University Baylor College of Dentistry, 3302 Gaston Ave, Dallas, TX, United States of America. .
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6: Title: Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors.
Authors: Tian, Ye, et.al. .
Journal: European journal of oral sciences (Eur J Oral Sci), Vol. 123 (6): 396-402, 2015 .
Snippet: In this study, we generated a Fam20B-floxed allele in mice and found that inactivating Fam20B in the dental epithelium leads to supernumerary maxillary and mandibular incisors.
Affiliation: Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University Baylor College of Dentistry, Dallas, TX, USA. Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China. .
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7: Title: Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis.
Authors: Wen, Jianzhong, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 111 (44): 15723-8, 2014 .
Snippet: Inactivating mutations in the GALT-II gene (B3GALT6) associated with Ehlers-Danlos syndrome cause proteoglycan maturation defects similar to FAM20B deletion.
Affiliation: Departments of Pharmacology and. Cellular and Molecular Medicine, and. Cellular and Molecular Medicine, and Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093. Departments of Pharmacology and jedixon@ucsd.edu. .
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8: Title: Five regulatory genes detected by matching signatures of eQTL and GWAS in psoriasis.
Authors: Yin, Xianyong, et.al. .
Journal: Journal of dermatological science (J Dermatol Sci), Vol. 76 (2): 139-42, 2014 .
Snippet: CONCLUSIONS: We identified FAM20B as a risk regulatory gene in the etiology of psoriasis at first time.
Affiliation: Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province 230032, China; Key Lab of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province 230032, China. Electronic address: xianyongyin@gmail.com. Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province 230032, China; Key Lab of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province 230032, China; Key Lab of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province 230032, China. .
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9: Title: Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans.
Authors: Koike, Toshiyasu, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (10): 6695-708, 2014 .
Snippet: Recently, we demonstrated that FAM20B is a kinase that phosphorylates the xylose (Xyl) residue in the glycosaminoglycan-protein linkage region of proteoglycans.
Affiliation: From the Department of Biochemistry, Kobe Pharmaceutical University, Higashinada-ku, Kobe 658-8558, Japan. .
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10: Title: EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.
Authors: Nadanaka, Satomi, et.al. .
Journal: Matrix biology : journal of the International Society for Matrix Biology (Matrix Biol), Vol. 35, 2014 .
Snippet: Interestingly, EXTL2 can transfer a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation.
Affiliation: Department of Biochemistry, Kobe Pharmaceutical University, Higashinada-ku, Kobe 658-8558, Japan. Department of Biochemistry, Kobe Pharmaceutical University, Higashinada-ku, Kobe 658-8558, Japan. Electronic address: kitagawa@kobepharma-u.ac.jp. .
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11: Title: Crystal structure of the Golgi casein kinase.
Authors: Xiao, Junyu, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 110 (26): 10574-9, 2013 .
Snippet: Fam20C is the Golgi casein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.
Affiliation: Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. .
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12: Title: EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.
Authors: Nadanaka, Satomi, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (13): 9321-33, 2013 .
Snippet: Here we show that EXTL2 transfers a GlcNAc residue to the tetrasaccharide linkage region that is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminates chain elongation.
Affiliation: Department of Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. .
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13: Title: Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.
Authors: Vogel, P, et.al. .
Journal: Veterinary pathology (Vet Pathol), Vol. 49 (6): 998-1017, 2012 .
Snippet: The FAM20 family of secreted proteins consists of three members (FAM20A, FAM20B, and FAM20C) recently linked to developmental disorders suggesting roles for FAM20 proteins in modulating biomineralization processes.
Affiliation: Department of Pathology, Lexicon Pharmaceuticals, Inc., 8800 Technology Forest Place, The Woodlands, TX 77381, USA. peter.vogel@stjude.org .
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14: Title: Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.
Authors: Eames, B Frank, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 7 (8): e1002246, 2011 .
Snippet: Refining previous in vitro reports, which demonstrated that fam20b and xylt1 were involved in PG synthesis, our in vivo analyses reveal that these genes function in cartilage matrix production and ultimately regulate the timing of skeletal development.
Affiliation: Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America. bfeame@uoneuro.uoregon.edu .
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15: Title: FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region.
Authors: Koike, Toshiyasu, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 421 (2): 157-62, 2009 .
Snippet: Overexpression of FAM20B increased the amount of both chondroitin sulfate and heparan sulfate in HeLa cells, whereas the RNA interference of FAM20B resulted in a reduction of their amount in the cells.
Affiliation: Department of Biochemistry, Kobe Pharmaceutical University, Higashinada-ku, Kobe 658-8558, Japan. .
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16: Title: FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells.
Authors: Nalbant, Demet, et.al. .
Journal: BMC genomics, Vol. 6, 2005 .
Snippet: Expression analysis revealed that the Fam20a gene was indeed differentially expressed during hematopoietic differentiation and that the other two family members (Fam20b and Fam20c) were also expressed during hematcpoiesis but that their mRNA levels did not vary significantly.
Affiliation: Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA. demet-nalbant@uiowa.edu .
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