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3 documents found
1: Title: Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes.
Authors: Pedersen, Helle Krogh, et.al. .
Journal: Frontiers in genetics (Front Genet), Vol. 8, 2017 .
Snippet: The analysis specifically revealed ten T2D candidate genes with probable roles in islets (ANPEP, HADH, FAM105A, PDLIM4, PDLIM5, MAP2K4, PPP2R5E, SNX13, GNAS, and FRS2), of which the last six are novel in the context of T2D and the data that went into the analysis.
Affiliation: Department of Bio and Health Informatics, Technical University of DenmarkKgs Lyngby, Denmark. Disease Systems Biology, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of CopenhagenCopenhagen, Denmark. .
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2: Title: Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.
Authors: Taneera, Jalal, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 24 (7): 1945-55, 2015 .
Snippet: Of them, five genes (GLR1A, PPP1R1A, PLCDXD3, FAM105A and ENO2) correlated positively with insulin secretion/negatively with HbA1c and one gene (GNG5) correlated negatively with insulin secretion/positively with HbA1c were followed up.
Affiliation: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden jalal.taneera@med.lu.se. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden Department of Cell Physiology and Metabolism, Université de Genève, University Medical Centre, 1 rue Michel-Servet, Geneva 4 1211, Switzerland. .
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3: Title: Functional screening for proapoptotic genes by reverse transfection cell array technology.
Authors: Mannherz, Otto, et.al. .
Journal: Genomics, Vol. 87 (5): 665-72, 2006 .
Snippet: For 6 of them apoptosis induction could be confirmed both by TUNEL assay and by FACS analysis of cells stained according to Nicoletti: 1 gene was not yet annotated for an apoptotic function (ST6GAL2), while 5 genes were without annotated function (FLJ20551, CXorf12, FAM105A, TMEM66, C19orf4).
Affiliation: Division of Molecular Genetics (B060), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. .
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