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12 documents found
1: Title: Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects.
Authors: Gorski, Marcin M, et.al. .
Journal: Haematologica, 2019 .
Snippet: Platelet candidate gene analysis revealed gene defects in 10/14 patients, which included ADRA2A, ARHGAP1, DIAPH1, EXOC1, FCGR2A, ITPR1, LTBP1, PTPN7, PTPN12, PRKACG, PRKCD, RAP1GAP, STXBP5L, and VWF.
Affiliation: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano. Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico. Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Universit&agrave degli Studi di Milano. Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Universit&agrave degli Studi di Milano flora.peyvandi@unimi.it. .
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2: Title: Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.
Authors: Lee, Byeonghyeon, et.al. .
Journal: Molecular neurobiology (Mol Neurobiol), 2018 .
Snippet: The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice.
Affiliation: Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea. School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea. Department of Aroma-applied Industry, Daegu Haany University, Gyeongsan, 38610, Republic of Korea. Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA. Department of Anatomy, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. BK21PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA. Department of Medicine, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, 29401, USA. Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea. Department of Anatomy, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. bokj@yuhs.ac. BK21PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. bokj@yuhs.ac. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. bokj@yuhs.ac. Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea. kimuk@knu.ac.kr. School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea. kimuk@knu.ac.kr. .
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3: Title: Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study.
Authors: McKay, James, et.al. .
Journal: PloS one, Vol. 12 (5): e0177775, 2017 .
Snippet: We also observed associations of borderline significance with the TIPARP rs2665390 polymorphism, which was previously found to be associated with ovarian and breast cancer, and with the EXOC1 rs13117307 polymorphism, which has been linked to cervical cancer in a large study in a Chinese population.
Affiliation: International Agency for Research on Cancer, Lyon, France. Centre International de Recherche en Infectiologie, International Center for Infectiology Research (CIRI), Lyon, France. Inserm, U1111, Lyon, France. Ecole Normale Supérieure de Lyon, Lyon, France. University Lyon 1, Lyon, France. CNRS, UMR5308, Lyon, France. Laboratoire d'Immunologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Lyon, France. .
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4: Title: Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.
Authors: Tanaka, Toshiaki, et.al. .
Journal: Cellular signalling (Cell Signal), Vol. 29, 2017 .
Snippet: Sec8 is one of the subunits of the exocyst, which is an evolutionarily conserved complex of eight proteins, comprising Sec3 (EXOC1), Sec5 (EXOC2), Sec6 (EXOC3), Sec8 (EXOC4), Sec10 (EXOC5), Sec15 (EXOC6), Exo70 (EXOC7), and Exo84 (EXOC8) subunits.
Affiliation: Department of Anatomy and Cell Biology, School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Japan; Department of Dentistry, Oral and Maxillofacial Surgery, Plastic and Reconstructive Surgery, School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Japan. Electronic address: ttanaka@med.id.yamagata-u.ac.jp. Department of Anatomy and Cell Biology, School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Japan. Department of Dentistry, Oral and Maxillofacial Surgery, Plastic and Reconstructive Surgery, School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Japan. .
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5: Title: Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans.
Authors: Keaton, Jacob M, et.al. .
Journal: PloS one, Vol. 11 (7): e0159977, 2016 .
Snippet: In single variant analyses, suggestively significant (Pinteraction<5×10-6) interactions were observed at several loci including LYPLAL1 (rs10746381), CHN2 (rs7796525), and EXOC1 (rs4289500).
Affiliation: Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America. Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America. University of Mississippi Medical Center, Jackson, Mississippi, United States of America. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America. Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America. Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America. Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Department of Internal Medicine - Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. .
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6: Title: Differential expression of six chicken genes associated with fatness traits in a divergently selected broiler population.
Authors: Wu, Xianwen, et.al. .
Journal: Molecular and cellular probes (Mol Cell Probes), Vol. 30 (1): 1-5, 2016 .
Snippet: The six significant SNPs are located in the kinase insert domain receptor (KDR), tumor suppressor candidate 3 (TUSC3), phosphoribosyl pyrophosphate amidotransferase (PPAT), exocyst complex component 1 (EXOC1), v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (MYBL2) and KIAA1211 (undefined) genes.
Affiliation: Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address: shouzhiwang@126.com. .
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7: Title: Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.
Authors: Mizuno, Seiya, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Genetic investigation revealed deletion of a > 1.2-Mb genomic region containing nine genes (Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, Nmu, Exoc1, and Cep135).
Affiliation: Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. .
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8: Title: Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.
Authors: Park, Sung Jin, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Notably, knockdown of DISC1 and EXOC1 elicited an exaggerated ER calcium response upon stimulation of IP3R agonists.
Affiliation: Department of Life Sciences, Pohang University of Science and Technology, 790-784, Republic of Korea. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, 790-784, Republic of Korea. Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan. Hotchkiss Brain Institute, Departments of Clinical Neurosciences, Cell Biology and Anatomy, and Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada T2N 4N1. .
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9: Title: Exocyst complex protein expression in the human placenta.
Authors: Gonzalez, I M, et.al. .
Journal: Placenta, Vol. 35 (7): 442-9, 2014 .
Snippet: RESULTS: The eight exocyst proteins, EXOC1, 2, 3, 4, 5, 6, 7, and 8, were found in the human placenta.
Affiliation: Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, USA. Electronic address: gonzalez.394@osu.edu. Department of Obstetrics and Gynecology, Ohio State University, Columbus, OH, USA. Electronic address: ackerman.72@osu.edu. Department of Biomedical Sciences, Western Michigan University School of Medicine, Kalamazoo, MI, USA. Electronic address: Dale.Vandre@med.wmich.edu. Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, USA. Electronic address: robinson.21@osu.edu. .
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10: Title: FAM190A deficiency creates a cell division defect.
Authors: Patel, Kalpesh, et.al. .
Journal: The American journal of pathology (Am J Pathol), Vol. 183 (1): 296-303, 2013 .
Snippet: FAM190A interacted with EXOC1 and Ndel1, which function in cytoskeletal organization and the cell division cycle.
Affiliation: Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. .
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11: Title: Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton.
Authors: Jourdain, Isabelle, et.al. .
Journal: Traffic (Copenhagen, Denmark) (Traffic), Vol. 13 (11): 1481-95, 2012 .
Snippet: SpSec3 shares many properties with its orthologs, and its mutants are rescued by human Sec3/EXOC1.
Affiliation: Cell Regulation Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK. isabelle.jourdain@cancer.org.uk .
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12: Title: Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.
Authors: Mukerji, Joya, et.al. .
Journal: Retrovirology, Vol. 9, 2012 .
Snippet: We report that wild-type, but not mutant Nef, was associated with 5 components of the exocyst complex (EXOC1, EXOC2, EXOC3, EXOC4, and EXOC6), an octameric complex that tethers vesicles at the plasma membrane, regulates polarized exocytosis, and recruits membranes and proteins required for nanotube formation.
Affiliation: Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA. .
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