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7 documents found
1: Title: ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells.
Authors: Krey, Jocelyn F, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), 2017 .
Snippet: We identified ELMOD1, a guanine nucleoside triphosphatase activating protein (GAP) for ARF6, as the most highly enriched ARF regulator in hair cells.
Affiliation: Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland OR 97239, USA. Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland OR, USA. The Jackson Laboratory, Bar Harbor, ME 04609, USA. Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland OR 97239, USA gillespp@ohsu.edu. .
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2: Title: ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.
Authors: Probert, Fay, et.al. .
Journal: Journal of proteome research (J Proteome Res), Vol. 14 (5): 2036-45, 2015 .
Snippet: In a further two KO lines, Elmod1 (MGI: 3583900) and Emc10 (MGI: 1916933), (1)H NMR metabolic differences were observed, but no other ex vivo changes were detected.
Affiliation: †Mary Lyon Centre, MRC Harwell, Oxfordshire OX11 0RD, United Kingdom. ‡Institute of Hepatology, Foundation for Liver Research, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom. .
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3: Title: Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases.
Authors: Ivanova, Anna A, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (16): 11111-21, 2014 .
Snippet: The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in loss of GAP activity.
Affiliation: From the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322. .
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4: Title: Functionally enigmatic genes: a case study of the brain ignorome.
Authors: Pandey, Ashutosh K, et.al. .
Journal: PloS one, Vol. 9 (2): e88889, 2014 .
Snippet: In several cases-ELMOD1, TMEM88B, and DZANK1-we have exploited sequence polymorphisms, large phenome data sets, and reverse genetic methods to evaluate the function of ignorome genes.
Affiliation: UT Center for Integrative and Translational Genomics and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America. UT Center for Integrative and Translational Genomics and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America ; St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America. Department of Biological Sciences, Bioinformatics Program, University of Memphis, Memphis, Tennessee, United States of America. .
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5: Title: ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases.
Authors: East, Michael P, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 287 (47): 39538-53, 2012 .
Snippet: We also provide initial evidence of the function of human ELMOD1 as an Arf family GAP at the Golgi.
Affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA. .
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6: Title: Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia.
Authors: Johnson, Kenneth R, et.al. .
Journal: PloS one, Vol. 7 (4): e36074, 2012 .
Snippet: Our finding connecting ELMOD1 deficiencies with stereocilia dysmorphologies thus establishes a link between the Ras superfamily of small regulatory GTPases and the actin cytoskeleton dynamics of hair cell stereocilia.
Affiliation: The Jackson Laboratory, Bar Harbor, Maine, USA. ken.johnson@jax.org .
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7: Title: ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
Authors: Bowzard, J Bradford, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 282 (24): 17568-80, 2007 .
Snippet: ELMOD2 is one of six human proteins that contain an ELMO domain, and a second member, ELMOD1, was also found to have Arl2 GAP activity.
Affiliation: Department of Biochemistry, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA. .
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