refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
10 documents found
1: Title: Efr3a Insufficiency Attenuates the Degeneration of Spiral Ganglion Neurons after Hair Cell Loss.
Authors: Hu, Haixia, et.al. .
Journal: Frontiers in molecular neuroscience (Front Mol Neurosci), Vol. 10, 2017 .
Snippet: Eighty-five requiring 3 (Efr3) is a plasma membrane protein conserved from yeast to human, and knockout of Efr3a was reported to facilitate the survival of hippocampal newborn neurons in adult mice.
Affiliation: Department of Otolaryngology and Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China. Shanghai Key Laboratory of Translational Medicine on Ear and Nose DiseasesShanghai, China. Ear Institute, Shanghai Jiao Tong University School of MedicineShanghai, China. Shanghai Advanced Research Institute, University of Chinese Academy of Sciences, Chinese Academy of SciencesShanghai, China. MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing UniversityNanjing, China. Institute of Neuroscience and State Key Laboratory of Neuroscience, Institute of Biological Science, Chinese Academy of SciencesShanghai, China. .
Related Products: order online
2: Title: Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway.
Authors: Qian, Qi, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 31 (5): 2104-2113, 2017 .
Snippet: Moreover, the brain-derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) signaling pathway was significantly enhanced in the hippocampus of Efr3a-deficient mice, as reflected by increased expression of BDNF, TrkB, and the downstream molecules, including phospho-MAPK and phospho-Akt.
Affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology, Ministry of Health of China. Key Laboratory of Neurobiology of Zhejiang Province, and. Department of Neurology, First Affiliated Hospital, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, China. Shanghai Advanced Research Institute, University of Chinese Academy of Sciences, Shanghai, China. Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China; and. Institute of Neuroscience, Shanghai Institute of Biological Science, Chinese Academy of Sciences, Shanghai, China. Shanghai Advanced Research Institute, University of Chinese Academy of Sciences, Shanghai, China; luobenyan@zju.edu.cn bsun@zju.edu.cn. Department of Neurology, First Affiliated Hospital, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, China; bsun@zju.edu.cn. Department of Neurobiology, Key Laboratory of Medical Neurobiology, Ministry of Health of China, bsun@zju.edu.cn. .
Related Products: order online
3: Title: The role of Efr3a in age-related hearing loss.
Authors: Hu, Haixia, et.al. .
Journal: Neuroscience, Vol. 341, 2017 .
Snippet: In addition, the p-Akt levels in the cochlear spiral ganglions were higher in adult Efr3a KD mice than in WT and OE mice, although there was no difference in Akt expression among the three groups.
Affiliation: Department of Otolaryngology & Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200092, China. Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200092, China. Department of Otolaryngology & Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200092, China. Electronic address: mingliangxiang@163.com. .
Related Products: order online
4: Title: Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale.
Authors: Dong, Jing-Ming, et.al. .
Journal: Science signaling (Sci Signal), Vol. 9 (432): rs4, 2016 .
Snippet: By focusing on this smaller data set, new partners for kindlin-2 were found, namely, the endocytosis-promoting proteins liprin β1 and EFR3A, but, contrary to previous reports, not the filamin-binding protein migfilin.
Affiliation: sGSK Group, Institute of Molecular and Cell Biology, Agency for Science Technology and Research, Proteos Building, 61 Biopolis Drive, Singapore 138673, Singapore. Quantitative Proteomics Group, Institute of Molecular and Cell Biology, Agency for Science Technology and Research, Singapore 138673, Singapore. Quantitative Proteomics Group, Institute of Molecular and Cell Biology, Agency for Science Technology and Research, Singapore 138673, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos Building, Singapore 138648, Singapore. sGSK Group, Institute of Molecular and Cell Biology, Agency for Science Technology and Research, Proteos Building, 61 Biopolis Drive, Singapore 138673, Singapore. Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos Building, Singapore 138648, Singapore. Department of Pharmacology, National University of Singapore, Singapore 117597, Singapore. ed.manser@imcb.a-star.edu.sg. .
Related Products: order online
5: Title: Expression of EFR3A in the mouse cochlea during degeneration of spiral ganglion following hair cell loss.
Authors: Nie, Chen, et.al. .
Journal: PloS one, Vol. 10 (1): e0117345, 2015 .
Snippet: In this study, we destroyed the hair cells of the mouse cochlea by co-administration of kanamycin and furosemide and then investigated the EFR3A expression during the induced spiral ganglion cell degeneration.
Affiliation: Department of Otolaryngology & Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
Related Products: order online
6: Title: [The spiral ganglion degeneration and the expression of EFR3A in the cochlea of the deaf mice induced by co-administration of kanamycin and furosemide].
Authors: Nie, Chen, et.al. .
Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi), Vol. 49 (11): 930-6, 2014 .
Snippet: OBJECTIVE: To investigate the spiral ganglion degeneration and the expression of EFR3A in the cochlea of the deaf mice induced by co-administration of kanamycin and furosemide.
Affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Email: mingliangxiang@163.com. .
Related Products: order online
7: Title: EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors.
Authors: Bojjireddy, Naveen, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 128 (1): 118-28, 2015 .
Snippet: siRNA-mediated depletion of EFR3A and EFR3B impaired the sustained phase of cytosolic Ca(2+) response to high concentration of AngII in HEK293 cells that express wild type but not truncated AGTR1 (AT1a receptor), missing the phosphorylation sites.
Affiliation: Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA. Swammerdam Institute for Life Sciences, University of Amsterdam, 1012 WX Amsterdam, The Netherlands. Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA ballat@mail.nih.gov. .
Related Products: order online
8: Title: Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress.
Authors: Fan, Alex Xiucheng, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 42 (12): 7625-41, 2014 .
Snippet: At the ATF3 gene, TFII-I binds immediately downstream of a Pol II peak located 5 kb upstream of exon 1. Induction of ATF3 expression increases transcription throughout the ATF3 gene locus which requires TFII-I and correlates with increased association of Pol II and Elongin A. Pull-down assays demonstrated that TFII-I interacts with Elongin A. Partial depletion of TFII-I expression caused a reduction in the association of Elongin A with and transcription of the DNMT1 and EFR3A genes without a decrease in Pol II recruitment.
Affiliation: Department of Biochemistry and Molecular Biology, Center for Epigenetics, Genetics Institute, Powell Gene Therapy Center, Gainesville, Florida, USA. Departmentof Biology, University of Crete, GR1409 Heraklion, Greece Divisionof Molecular Oncology, Biomedical Sciences Research Center "Alexander Fleming", Vari GR 16672, Greece. Departmentof Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA. Divisionof Molecular Oncology, Biomedical Sciences Research Center "Alexander Fleming", Vari GR 16672, Greece. Department of Biochemistry and Molecular Biology, Center for Epigenetics, Genetics Institute, Powell Gene Therapy Center, Gainesville, Florida, USA Departmentof Biology, University of Crete, GR1409 Heraklion, Greece Divisionof Molecular Oncology, Biomedical Sciences Research Center "Alexander Fleming", Vari GR 16672, Greece Departmentof Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA strouboulis@fleming.gr. Department of Biochemistry and Molecular Biology, Center for Epigenetics, Genetics Institute, Powell Gene Therapy Center, Gainesville, Florida, USA jbungert@ufl.edu. .
Related Products: order online
9: Title: Rare deleterious mutations of the gene EFR3A in autism spectrum disorders.
Authors: Gupta, Abha R, et.al. .
Journal: Molecular autism (Mol Autism), Vol. 5, 2014 .
Snippet: Furthermore, EFR3A is expressed in cortical neurons, including pyramidal neurons, during human fetal brain development in a pattern consistent with ASD-related genes, and it is strongly co-expressed (P < 2.2 × 10(-16), Wilcoxon test) with a module of genes significantly associated with ASD.
Affiliation: Department of Pediatrics and Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA. Scholar Rock, LLC, 300 Third Street, 4th floor, Cambridge, MA 02142, USA. Department of Neurobiology, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA ; College of Pharmacy, University of South Florida, Tampa, FL 33612, USA. Department of Neurobiology, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA ; Department of Life Science, Chung-Ang University, Seoul, Korea. Department of Psychiatry and Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA. Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT 06520, USA. Department of Genetics, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06520, USA. Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Program on Neurogenetics, Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA. Program on Neurogenetics, Child Study Center, Department of Psychiatry, Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Department of Neurobiology, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA. Departments of Biostatistics and Genetics, Yale School of Medicine, New Haven, CT 06520, USA. Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. .
Related Products: order online
10: Title: Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.
Authors: Zhou, Donger, et.al. .
Journal: PloS one, Vol. 8 (1): e53310, 2013 .
Snippet: Most of these mutations including OR6X1, SLC15A3, KRTHB4, RBFOX1, LAMA3, CDH20, BIRC6, NMBR, GLCCI1, EFR3A, and FTHL17 were newly reported in colorectal adenomas.
Affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, the Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China. .
Related Products: order online
Documents per page: 20 | 50 | 100