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33 documents found
1: Title: New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.
Authors: Perez-Añorve, Isidro X, et.al. .
Journal: Molecular oncology (Mol Oncol), Vol. 13 (5): 1249-1267, 2019 .
Snippet: The transcriptomic landscape resulting from knockdown of miR-122 in radioresistant cells showed modulation of the ZNF611, ZNF304, RIPK1, HRAS, DUSP8 and TNFRSF21 genes.
Affiliation: Posgrado en Ciencias Naturales e Ingenieria, Division de Ciencias Naturales e Ingenieria, Universidad Autonoma Metropolitana, Mexico City, Mexico. Departamento de Ciencias Naturales, Universidad Autonoma Metropolitana, Unidad Cuajimalpa, Mexico City, Mexico. Laboratorio de Genomica del Cancer, Instituto Nacional de Medicina Genomica, Mexico City, Mexico. Laboratorio de Virologia y Epigenetica del Cancer, Facultad de Ciencias Quimico Biologicas, Universidad Autonoma de Guerrero, Chilpancingo, Mexico. Unidad de Radioterapia, Instituto Nacional de Cancerologia, Mexico City, Mexico. Laboratorio de Medicina Genomica, Hospital Regional "1° de Octubre", Mexico City, Mexico. Laboratorio de Biologia de la Reproduccion, Instituto Nacional de Pediatría, Mexico City, Mexico. Unidad de Investigacion Biomedica en Cancer-Laboratorio de Virus y Cancer, Instituto Nacional de Cancerologia, Mexico City, Mexico. Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico. .
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2: Title: Dual-specificity phosphatases regulate mitogen-activated protein kinase signaling in adipocytes in response to inflammatory stress.
Authors: Ferguson, Bradley S, et.al. .
Journal: Cellular signalling (Cell Signal), Vol. 53, 2019 .
Snippet: Using tumor necrosis factor α (TNFα) in 3 T3-L1 adipocytes as a model of inflammation, we report that TNFα-mediated induction of Dusp1, Dusp8 and Dusp16 modulated the transient regulation of MAPK (i.e., ERK, JNK, and p38) phosphorylation and subsequent inflammatory gene expression.
Affiliation: Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, United States. Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, United States. Electronic address: rfmorris@uncg.edu. .
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3: Title: Antisense Oligonucleotides against miR-21 Inhibit the Growth and Metastasis of Colorectal Carcinoma via the DUSP8 Pathway.
Authors: Ding, Tao, et.al. .
Journal: Molecular therapy. Nucleic acids (Mol Ther Nucleic Acids), Vol. 13, 2018 .
Snippet: Finally, downregulation of DUSP8 could abrogate the effects of ASOs against miR-21 on the proliferation and migration of CRC cells, as well as altered transduction of the AKT and ERK signaling pathway.
Affiliation: Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Guizhou 563000, China. Department of Medical Physics, Zunyi Medical University, Guizhou 563000, China. Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, Guizhou 550004, China. Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Guizhou 563000, China. Electronic address: xulinzhouya@163.com. .
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4: Title: PTPRC Expression in Blood is Downregulated in Parkinson's and Progressive Supranuclear Palsy Disorders.
Authors: Bottero, Virginie, et.al. .
Journal: Journal of Parkinson's disease (J Parkinsons Dis), Vol. 8 (4): 529-537, 2018 .
Snippet: METHODS: In this study, we tested the phosphatases DUSP8 and PTPRC for their diagnostic potential using quantitative PCR assays, in blood of 138 samples from participants nested in the Parkinson's Disease Biomarkers Program.
Affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. .
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5: Title: DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.
Authors: Liu, Ruijie, et.al. .
Journal: Circulation research (Circ Res), Vol. 119 (2): 249-60, 2016 .
Snippet: OBJECTIVE: To examine DUSP8 as a regulator of MAPK signaling in the heart and its impact on ventricular and cardiac myocyte growth dynamics.
Affiliation: From the Department of Pediatrics, University of Cincinnati (R.L., J.H.v.B., A.J.Y., R.J.V., M.M., J.D.M.) and Howard Hughes Medical Institute (J.D.M.), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, St. Paul (J.H.v.B.). From the Department of Pediatrics, University of Cincinnati (R.L., J.H.v.B., A.J.Y., R.J.V., M.M., J.D.M.) and Howard Hughes Medical Institute (J.D.M.), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, St. Paul (J.H.v.B.). jeff.molkentin@cchmc.org. .
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6: Title: Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells.
Authors: Miao, YiMing, et.al. .
Journal: Pharmaceutical biology (Pharm Biol), Vol. 54 (4): 660-6, 2016 .
Snippet: RESULTS AND CONCLUSION: DMU-212 was found to regulate a diverse range of genes, including cytokines (IL8, selectin E, MPZL2, EGR1, CCL20, ITGB8, CXCL1, VCAM1, KITLG, and AREG), transport proteins (TRPC4, SLC41A2, SLC17A5, and CREB5), metabolism (CYP1B1, CYP1A1, PDK4, CSNK1G1, MVK, TCEB3C, and CDKN3), enzymes (RAB23, SPHK1, CHSY3, PLAU, PLA2G4C, and MMP10), and genes involved in signal transduction (TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and GEM), cell migration and angiogenesis (ERRFI1, HBEGF, and NEDD9), and apoptosis (TNFSF15, TNFRSF9, CD274, BCL2L11, BIRC3, TNFAIP3, and TIFA), as well as other genes with unknown function (PGM5P2, SNORD1142, LOC151760, KRTAP5-2, C1orf110, SNORA14A, MIR31, C2CD4B, SCARNA4, C2orf66, SC4MOL, LOC644714, and LOC283392).
Affiliation: a College of Bioengineering, Henan University of Technology , Zhengzhou , China. .
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7: Title: Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8.
Authors: Smeeton, Joanna, et.al. .
Journal: Journal of the American Society of Nephrology : JASN (J Am Soc Nephrol), Vol. 27 (5): 1465-77, 2016 .
Snippet: Six genes with expression in ureteric tip cells, including Wnt11, were downregulated, whereas the expression of dual-specificity phosphatase 8 (DUSP8) was upregulated.
Affiliation: Program in Developmental and Stem Cell Biology, and Departments of Paediatrics, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Program in Developmental and Stem Cell Biology, and. Program in Developmental and Stem Cell Biology, and Departments of Paediatrics, and Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada; and norman.rosenblum@sickkids.ca. .
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8: Title: Micro-RNA 21Targets dual specific phosphatase 8 to promote collagen synthesis in high glucose-treated primary cardiac fibroblasts.
Authors: Liu, Shulei, et.al. .
Journal: The Canadian journal of cardiology (Can J Cardiol), Vol. 30 (12): 1689-99, 2014 .
Snippet: Our study also identified a direct target of miR-21, DUSP8, which regulates cell proliferation and collagen synthesis in cardiac fibroblasts through p38 and c-Jun N-terminal kinase (JNK)/stress-activated kinase (SAPK) signalling.
Affiliation: Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Zengcheng People's Hospital, Guangzhou, China. Electronic address: chenxch@mail.sysu.edu.cn. .
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9: Title: Genetic and epigenetic control of metabolic health.
Journal: Molecular metabolism (Mol Metab), Vol. 2 (4): 337-47, 2013 .
Snippet: Some of the familial aggregation as well as many of the effects of environmental exposures, may reflect epigenetic processes.
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10: Title: Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions.
Authors: Kidane, Yared H, et.al. .
Journal: BMC microbiology (Bmc Microbiol), Vol. 13, 2013 .
Snippet: These processes contained both immune response-inducing genes such as MALT1, SERPINE1, ICAM1, and IL8, and immune response-repressing genes such as DUSP8, DUSP6, and SPRED2.
Affiliation: Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA. lawrence@vbi.vt.edu. .
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11: Title: Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Authors: Huang, Zheren, et.al. .
Journal: The International journal of neuroscience (Int J Neurosci), Vol. 123 (11): 802-9, 2013 .
Snippet: The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4 h of reperfusion in rat hippocampi.
Affiliation: 1Laboratory Center for Basic Medical Sciences, Nanjing Medical University , Nanjing , P.R. China. .
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12: Title: Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells.
Authors: Juknat, Ana, et.al. .
Journal: PloS one, Vol. 8 (4): e61462, 2013 .
Snippet: Results clearly link the effects of CBD and THC to inflammatory signaling pathways and identify new cannabinoid targets in the MAPK pathway (Dusp1, Dusp8, Dusp2), cell cycle related (Cdkn2b, Gadd45a) as well as JAK/STAT regulatory molecules (Socs3, Cish, Stat1).
Affiliation: The Dr. Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Sackler Faculty of Medicine, Physiology and Pharmacology Department, Tel Aviv University, Tel Aviv, Israel. .
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13: Title: Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
Authors: Dayeh, T A, et.al. .
Journal: Diabetologia, Vol. 56 (5): 1036-46, 2013 .
Snippet: Successful DNA methylation data were generated for 16 of these 19 CpG-SNP loci, representing the candidate genes TCF7L2, KCNQ1, PPARG, HHEX, CDKN2A, SLC30A8, DUSP9, CDKAL1, ADCY5, SRR, WFS1, IRS1, DUSP8, HMGA2, TSPAN8 and CHCHD9.
Affiliation: Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Scania University Hospital, Jan Waldenströmsgata 35, 205 02 Malmö, Sweden. .
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14: Title: Differential regulation of M3/6 (DUSP8) signaling complexes in response to arsenite-induced oxidative stress.
Authors: Oehrl, Wolf, et.al. .
Journal: Cellular signalling (Cell Signal), Vol. 25 (2): 429-38, 2013 .
Snippet: M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs and is found in a complex with these kinases, along with other pathway components, held together by scaffold proteins.
Affiliation: Biomedical Sciences Research Center "Alexander Fleming", Vari 166 72, Greece. .
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15: Title: Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Authors: Okami, Nobuya, et.al. .
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab), Vol. 33 (1): 106-14, 2013 .
Snippet: Another key finding of the present study was that knockdown of DUSP8 in primary cultured cortical neurons that were subjected to oxygen-glucose deprivation diminished rosiglitazone's effect on downregulation of JNK phosphorylation.
Affiliation: Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, CA, USA. .
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16: Title: Ubiquitous [Na+]i/[K+]i-sensitive transcriptome in mammalian cells: evidence for Ca(2+)i-independent excitation-transcription coupling.
Authors: Koltsova, Svetlana V, et.al. .
Journal: PloS one, Vol. 7 (5): e38032, 2012 .
Snippet: Among the ubiquitous Na(+) (i)/K(+) (i)-sensitive genes whose expression was regulated independently of the presence of Ca(2+) chelators by more than 3-fold, we discovered several transcription factors (Fos, Jun, Hes1, Nfkbia), interleukin-6, protein phosphatase 1 regulatory subunit, dual specificity phosphatase (Dusp8), prostaglandin-endoperoxide synthase 2, cyclin L1, whereas expression of metallopeptidase Adamts1, adrenomedulin, Dups1, Dusp10 and Dusp16 was detected exclusively in Ca(2+)-depleted cells.
Affiliation: Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) - Technopôle Angus, Montreal, PQ, Canada. .
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17: Title: Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.
Authors: Cotsiki, Marina, et.al. .
Journal: Cellular signalling (Cell Signal), Vol. 24 (3): 664-76, 2012 .
Snippet: M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK.
Affiliation: Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece. .
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18: Title: Proteomic and genomic modulations induced by γ-irradiation of human blood lymphocytes.
Authors: Turtoi, Andrei, et.al. .
Journal: International journal of radiation biology (Int J Radiat Biol), Vol. 86 (10): 888-904, 2010 .
Snippet: The most radiation responsive genes and proteins indicated alterations of cellular structure (ß-actin, talin-1 [TLN1], talin-2, zyxin-2), immune and defence reactions (major histocompatibility complex binding protein-2 [MBP2], interleukin-17E and interferon-γ), cell cycle control (cyclin-dependent kinase inhibitor-1A [CDKN1A], mouse double minute-2, annexin-A6 [ANXA6], growth arrest and DNA-damage-inducible protein-α [GADD45A], proliferating cell nuclear antigen [PCNA], dual specificity phosphatase-2 and 8 [DUSP8]) as well as detoxification processes (peroxin-1) and apoptosis (B-cell lymphoma-2 binding component-3 [BBC3]).
Affiliation: Department of Safety and Radiation Protection, Research Centre Jülich, Germany. a.turtoi@ulg.ac.be .
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19: Title: Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.
Authors: Turtoi, Andrei, et.al. .
Journal: International journal of radiation biology (Int J Radiat Biol), Vol. 85 (5): 403-12, 2009 .
Snippet: Method: BBC3 (B-cell lymphoma 2 binding component 3), CD69 (cluster of differentiation 69), CDKN1A (cyclin-dependent kinase inhibitor 1A), DUSP8 (dual specificity phosphatase 8) EGR1 (early growth response 1), EGR4 (early growth response 4), GADD45A (growth arrest and DNA-damage-inducible, alpha), GRAP (growth factor receptor-bound protein 2-related adaptor protein), LAP1B (TOR1AIP1; torsin A interacting protein 1), IFNG (interferon gamma), ISG20L1 (interferon-stimulated exonuclease gene 20kDa - like 1), c-JUN (jun oncogene), MDM2 (mouse double minute 2), PCNA (proliferating cell nuclear antigen), PLK2 (polo-like kinase 2), RND1 (rho family GTPase 1), TNFSF9 (tumour necrosis factor superfamily member 9) and TRAF4 (tumour necrosis factor receptor-associated factor 4). RESULTS: The expressions of the 18 genes, except GRAP, were up-regulated following exposure to alpha-radiation.
Affiliation: Research Centre Julich, Department of Safety and Radiation Protection, Laboratory of Radiation Biology, Germany. a.turtoi@ulg.ac.be .
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20: Title: Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Journal: Cancer metastasis reviews (Cancer Metast Rev), Vol. 27 (2): 253-61, 2008 .
Snippet: The final group consists of three MKPs DUSP8/hVH-5, DUSP10/MKP-5 and DUSP16/MKP-7 all of which preferentially inactivate the stress-activated p38 and JNK MAP kinases.
Affiliation: Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK. s.m.keyse@dundee.ac.uk .
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