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4 documents found
1: Title: Directed evolution of human scFvs in DT40 cells.
Authors: Lim, Alfred W Y, et.al. .
Journal: Protein engineering, design & selection : PEDS (Protein Eng Des Sel), Vol. 29 (2): 39-48, 2016 .
Snippet: From this library, we successfully isolated scFvs that bound the spliceosome factor CWC15 and the cytokine human IFN╬│.
Affiliation: Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK jes@mrc-lmb.cam.ac.uk. .
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2: Title: Screening for JH1 genetic defect carriers in Jersey cattle by a polymerase chain reaction and restriction fragment length polymorphism assay.
Authors: Zhang, Yi, et.al. .
Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc (J Vet Diagn Invest), Vol. 27 (5): 596-9, 2015 .
Snippet: The genetic basis has been identified as a cytosine to thymine mutation in the CWC15 gene that changes an amino acid from arginine to a stop code.
Affiliation: National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture, China Agricultural University, Beijing, China (Y Zhang, Huang, Lu, L Wang, Fang, Y Wang, S Zhang)Beijing Shounong Xumu Fazhan Co Ltd., Beijing, China (Guo, Liu). National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture, China Agricultural University, Beijing, China (Y Zhang, Huang, Lu, L Wang, Fang, Y Wang, S Zhang)Beijing Shounong Xumu Fazhan Co Ltd., Beijing, China (Guo, Liu) zhang62733697@163.com. .
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3: Title: CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.
Authors: van Maldegem, Febe, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 43 (14): 7058-69, 2015 .
Snippet: Here we show that in vitro CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex.
Affiliation: MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK Febe.vanMaldegem@crick.ac.uk. MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. Department of Medicine and Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK car@mrc-lmb.cam.ac.uk. .
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4: Title: Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle.
Authors: Sonstegard, Tad S, et.al. .
Journal: PloS one, Vol. 8 (1): e54872, 2013 .
Snippet: By combining SNP analysis of whole-genome sequences aligned to the JH1 interval and subsequent SNP validation a nonsense mutation in CWC15 was identified as the likely causative mutation underlying the fertility phenotype.
Affiliation: Bovine Functional Genomics, United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA. .
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