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23 documents found
1: Title: MrpL35, a mitospecific component of mitoribosomes, plays a key role in cytochrome c oxidase assembly.
Authors: Box, Jodie M, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), 2017 .
Snippet: Our findings indicate that MrpL35, with its partner Mrp7, play a key role in coordinating the synthesis of the Cox1 subunit with its assembly into the COX enzyme, and in a manner which involves the Cox14 and Coa3 proteins.
Affiliation: Dept. of Biological Sciences, Marquette University, Milwaukee, WI, USA. Dept. of Biological Sciences, Marquette University, Milwaukee, WI, USA rosemary.stuart@marquette.edu. .
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2: Title: The Cox1 C-terminal domain is a central regulator of cytochrome c oxidase biogenesis in yeast mitochondria.
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (26): 10912-10925, 2017 .
Snippet: We previously reported that the last 15 residues of the Cox1 C terminus regulate Cox1 synthesis by modulating an interaction of Mss51 with Cox14, another component of the COA complexes.
Affiliation: From the Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico. the Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia. the Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands, and. the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853. From the Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico, xperez@ifc.unam.mx. .
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3: Title: Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis.
Authors: Dela Cruz, Richard, et.al. .
Journal: Microbial cell (Graz, Austria) (Microb Cell), Vol. 3 (7): 275-284, 2016 .
Snippet: The Cox1 mutant allele fails to support respiratory growth in yeast lacking Cox17, Cox19, Coa1, Coa2, Cox14 or Shy1, demonstrating its specific suppressor activity for cox23∆ cells.
Affiliation: University of Utah Health Sciences Center, Departments of Medicine and Biochemistry, Salt Lake City, Utah 84132, USA. ; Present address: Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. University of Utah Health Sciences Center, Departments of Medicine and Biochemistry, Salt Lake City, Utah 84132, USA. .
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4: Title: A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis.
Authors: Bourens, Myriam, et.al. .
Journal: EMBO reports (Embo Rep), Vol. 18 (3): 477-494, 2017 .
Snippet: Furthermore, whereas human COX14 and COA3 have been proposed to affect COX1 mRNA translation, our data indicate that CMC1 regulates turnover of newly synthesized COX1 prior to and during COX1 maturation, without affecting the rate of COX1 synthesis.
Affiliation: Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA abarrientos@med.miami.edu. Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. .
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5: Title: Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.
Journal: Cell, Vol. 167 (2): 471-483.e10, 2016 .
Snippet: Ribosomes expressing mitochondrial-encoded COX1 mRNA selectively engage with cytochrome c oxidase assembly factors in the inner membrane.
Affiliation: Department of Cellular Biochemistry, University Medical Centre Göttingen, GZMB, 37073 Göttingen, Germany. Department of Biochemistry and Functional Proteomics, Faculty of Biology, University Freiburg, 79104 Freiburg, Germany. Department of Biochemistry and Functional Proteomics, Faculty of Biology, University Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany. Department of Cellular Biochemistry, University Medical Centre Göttingen, GZMB, 37073 Göttingen, Germany; Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany. Electronic address: peter.rehling@medizin.uni-goettingen.de. .
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6: Title: A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria.
Authors: Mayorga, Juan Pablo, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (17): 9343-55, 2016 .
Snippet: This protein activates translation of the COX1 mRNA by acting on the COX1 5'-UTR, and, in addition, it interacts with the newly synthesized Cox1 protein in high molecular weight complexes that include the factors Coa3 and Cox14.
Affiliation: From the Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. the Department of Biochemistry and Molecular Biology, School of Biomedical Sciences Monash University, Clayton, Victoria 3800, Australia, and. the Division of Basic Research, National Institute of Cancer (INCan), Mexico City 14080, Mexico. From the Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico, xperez@ifc.unam.mx. .
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7: Title: Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature.
Authors: Ostergaard, Elsebet, et.al. .
Journal: Journal of medical genetics (J Med Genet), Vol. 52 (3): 203-7, 2015 .
Snippet: COA3 exists in an early COX assembly complex that contains COX1 and other COX assembly factors including COX14 (C12orf62), another single pass transmembrane protein that also plays a role in coupling COX1 synthesis with holoenzyme assembly.
Affiliation: Department of Clinical Genetics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. Department of Human Genetics and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Department of Pediatrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. Department of Genomic Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. Department of Human Genetics and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Department of Neurology and Neuromuscular Research Unit, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark. .
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8: Title: Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex.
Authors: McStay, Gavin P, et.al. .
Journal: FEBS letters (Febs Lett), Vol. 587 (7): 943-9, 2013 .
Snippet: Cox14p and Coa3p have been shown to regulate translation of the mitochondrial COX1 mRNA and to be required for assembly of cytochrome oxidase.
Affiliation: Department of Biological Sciences, Columbia University, New York, NY 10027, USA. .
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9: Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Authors: Szklarczyk, Radek, et.al. .
Journal: Genome biology (Genome Biol), Vol. 13 (2): R12, 2012 .
Snippet: For the human gene C12orf62, the ortholog of S. cerevisiae COX14, we specifically confirm its role in negative regulation of the translation of cytochrome c oxidase.
Affiliation: Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands. radek@cmbi.ru.nl .
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10: Title: Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.
Journal: American journal of human genetics (Am J Hum Genet), Vol. 90 (1): 142-51, 2012 .
Snippet: We investigated a family in which the index subject presented with severe congenital lactic acidosis and dysmorphic features associated with a cytochrome c oxidase (COX)-assembly defect and a specific decrease in the synthesis of COX I, the subunit that nucleates COX assembly.
Affiliation: Department of Human Genetics and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. .
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11: Title: Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae.
Authors: Fontanesi, Flavia, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 286 (1): 555-66, 2011 .
Snippet: During translation and post-translationally, newly synthesized Cox1 physically interacts with a complex of proteins involving Ssc1, Mss51, and Cox14, which eventually hand over Cox1 to the assembly pathway.
Affiliation: Departments of Neurology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. .
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12: Title: Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria.
Authors: Mick, David U, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 191 (1): 141-54, 2010 .
Snippet: Coa3 and Cox14 promote formation of the latent state and thus down-regulate COX1 expression.
Affiliation: Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, D-79104 Freiburg, Germany. .
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13: Title: The carboxyl-terminal end of Cox1 is required for feedback assembly regulation of Cox1 synthesis in Saccharomyces cerevisiae mitochondria.
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 285 (45): 34382-9, 2010 .
Snippet: Furthermore, these deletions reduced the strength of the Mss51-Cox14 interaction as detected by co-immunoprecipitation, confirming the importance of the Cox1 C-terminal residues for Mss51 sequestration.
Affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México DF 04510, México. .
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14: Title: Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria.
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 20 (20): 4371-80, 2009 .
Snippet: Mss51 does not stably interact with newly synthesized Cox1 in a mutant lacking Cox14, suggesting that the failure of nuclear cox14 mutants to decrease Cox1 synthesis, despite their inability to assemble cytochrome c oxidase, is due to a failure to sequester Mss51.
Affiliation: Departamento de Bioquímica, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F. 04510, México. .
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15: Title: Chapter 11 Supercomplex organization of the yeast respiratory chain complexes and the ADP/ATP carrier proteins.
Journal: Methods in enzymology (Methods Enzymol), Vol. 456, 2009 .
Snippet: Recent evidence indicates that a diversity in the populations of the cytochrome bc(1)-COX supercomplexes exists within the mitochondria, because different subpopulations of this supercomplex have been shown to further interact with distinct partner complexes (e.g., the TIM23 machinery and also the Shy1/Cox14 proteins).
Affiliation: Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA. .
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16: Title: Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
Authors: Pierrel, Fabien, et.al. .
Journal: The EMBO journal (Embo J), Vol. 26 (20): 4335-46, 2007 .
Snippet: The interaction between Coa1 and Cox1, and the physical and genetic interactions between Coa1 and Mss51, Shy1 and Cox14 suggest that Coa1 coordinates the transition of newly synthesized Cox1 from the Mss51:Cox14 complex to the heme a cofactor insertion involving Shy1.
Affiliation: Department of Medicine, University of Utah Health Sciences Center, University of Utah, Salt Lake City, UT 84132, USA. .
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17: Title: Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
Authors: Mick, David U, et.al. .
Journal: The EMBO journal (Embo J), Vol. 26 (20): 4347-58, 2007 .
Snippet: We report that Shy1 promotes complex IV biogenesis through association with different protein modules; Shy1 interacts with Mss51 and Cox14, translational regulators of Cox1.
Affiliation: Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, Freiburg, Germany. .
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18: Title: Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae.
Authors: Zambrano, Andrea, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 18 (2): 523-35, 2007 .
Snippet: The mp15 polypeptide is not detected in cox14 mutants that express Cox1p normally.
Affiliation: Department of Neurology and Biochemistry and Molecular Biology, The John T. Macdonald Foundation Center for Medical Genetics, University of Miami School of Medicine, Miami, FL 33136, USA. .
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19: Title: COX24 codes for a mitochondrial protein required for processing of the COX1 transcript.
Authors: Barros, Mario H, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 281 (6): 3743-51, 2006 .
Snippet: Based on the analysis of a cox14-cox24 double mutant, we propose that the other function of Cox24p is related to translation of the COX1 mRNA.
Affiliation: Department of Biological Sciences, Columbia University, New York, New York 10027, USA. .
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20: Title: Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.
Authors: Barrientos, Antoni, et.al. .
Journal: The EMBO journal (Embo J), Vol. 23 (17): 3472-82, 2004 .
Snippet: An important exception is a null mutation in COX14, which by itself or in combination with other COX mutations does not affect Cox1p synthesis.
Affiliation: Department of Biological Sciences, Columbia University, New York, NY, USA. abarrientos@med.miami.edu .
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