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14 documents found
1: Title: Overexpression of CMTM7 inhibits cell growth and migration in liver cancer.
Authors: Huang, Zi-Ming, et.al. .
Journal: The Kaohsiung journal of medical sciences (Kaohsiung J Med Sci), 2019 .
Snippet: Further analysis revealed that CMTM7 suppressed AKT signaling and induced cell cycle arrest at the G0/G1 phase in the liver cancer cells, likely as the consequent of decreased levels of cyclin D1, cyclin-dependent kinase 4 (CDK4), and CDK6, and increased p27 expression.
Affiliation: Department of Emergency Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Department of Emergency Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China. Department of Respiratory Care, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China. Suzhou Institute of Systems Medicine, Center for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, Jiangsu, China. .
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2: Title: SOX10-dependent CMTM7 expression inhibits cell proliferation and tumor growth in gastric carcinoma.
Authors: Jin, Yongdong, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 507 (1-4): 91-99, 2018 .
Snippet: CMTM7 has also been reported to be down-regulated in some digestive system tumors, but the expression patterns and pathological role of CMTM7 in gastric cancer remains unclear.
Affiliation: Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. Electronic address: gqjia2009@163.com. .
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3: Title: Copy number variation and regions of homozygosity analysis in patients with M√úLLERIAN aplasia.
Authors: Demir Eksi, Durkadin, et.al. .
Journal: Molecular cytogenetics (Mol Cytogenet), Vol. 11, 2018 .
Snippet: Of interest, eight candidate genes suggested by human or animal studies (RBM8A, CMTM7, CCR4, TRIM71, CNOT10, TP63, EMX2, and CFTR) reside within these ROH.
Affiliation: Department of Medical Biology, Alanya Alaaddin Keykubat University, Faculty of Medicine, Antalya, Turkey. 2Guangxi Maternal and Child Health Hospital, Nanning, China. 3Department of Pathology, Harvard Medical School, Boston, MA 02115 USA. 4Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115 USA. 5Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127 China. 6Department of Obstetrics and Gynecology, Akdeniz University, Faculty of Medicine, Antalya, Turkey. 7Section of Reproductive Endocrinology, Infertility, & Genetics, Department of Obstetrics & Gynecology Medical College of Georgia at Augusta University, Augusta, GA USA. 8Department of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, 1120 15th Street, CA2041, Augusta, GA 30912 USA. 9Department of Medical Biology and Genetics, Akdeniz University, Faculty of Medicine, 07058 Antalya, Turkey. .
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4: Title: A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3.
Authors: Williams, Lacey S, et.al. .
Journal: Molecular cytogenetics (Unknown Journal), Vol. 9, 2016 .
Snippet: Reduced expression was seen for CMTM7 and CCR4 on 3p22.3, while increased expression was observed for IL32 and MEFV on 16p13.3.
Affiliation: Section of Reproductive Endocrinology, Infertility, & Genetics, Department of Obstetrics & Gynecology, Medical College of Georgia, Augusta University, Augusta, GA USA. Research Group Development and Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany. American Society for Reproductive Medicine, Birmingham, AL USA. Section of Reproductive Endocrinology, Infertility, & Genetics, Department of Obstetrics & Gynecology, Medical College of Georgia, Augusta University, Augusta, GA USA ; Department of Neuroscience & Regenerative Medicine, Augusta University, Augusta, GA 30912 USA ; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912 USA. .
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5: Title: CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.
Authors: Liu, Baocai, et.al. .
Journal: Oncotarget, Vol. 6 (38): 41092-107, 2015 .
Snippet: Together, our findings highlight the role of CMTM7 in the regulation of EGFR signaling in tumor cells, revealing CMTM7 as a novel molecule related to Rab5 activation.
Affiliation: Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing, China. Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, China. Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China. Peking University Medical and Health Analysis Center, Beijing, China. .
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6: Title: Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets.
Authors: Delic, Sabit, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 54 (7): 433-43, 2015 .
Snippet: Using a human phosphokinase protein expression profiling assay, we can provide first insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation.
Affiliation: Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany. Department of Neurosurgery and, Regensburg University Hospital, Regensburg, Germany. Wilhelm Sander-NeuroOncology Unit, Regensburg University Hospital, Regensburg, Germany. Institute of Biochemistry, Emil-FischerCenter, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany. .
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7: Title: A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.
Authors: Zhang, Yanfei, et.al. .
Journal: International immunology (Int Immunol), Vol. 26 (1): 47-57, 2014 .
Snippet: Here, we show that the MARVEL-domain-containing membrane protein CMTM7 (CKLF-like MARVEL transmembrane domain-containing 7) plays a critical role in BCR expression and survival in B-1a cells.
Affiliation: Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. .
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8: Title: Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer.
Authors: Liu, Qiang, et.al. .
Journal: Chinese medical journal (Chinese Med J-peking), Vol. 126 (16): 3006-12, 2013 .
Snippet: BACKGROUND: CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) located at 3p22.3, is a frequent deletion site and a tumor suppressor gene (TSG) locus in many cancer, which suggests CMTM7 may be a potential TSG.
Affiliation: Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China. .
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9: Title: A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.
Authors: Li, H, et.al. .
Journal: Oncogene, Vol. 33 (24): 3109-18, 2014 .
Snippet: Moreover, CMTM7 could promote epidermal growth factor receptor (EGFR) internalization, and further suppress AKT signaling pathway.
Affiliation: 1] Department of Immunology, Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing, China [2] Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China. Cancer Epigenetics Laboratory, State Key Laboratory of Oncology in South China, Department of Clinical Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong and CUHK Shenzhen Research Institute, Hong Kong. Department of Immunology, Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing, China. Department of Pathology, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Department of Otolaryngology/Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China. Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China. .
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10: Title: Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.
Authors: Miyazaki, Atsuko, et.al. .
Journal: PloS one, Vol. 7 (2): e31829, 2012 .
Snippet: RNA-interference-mediated knockdown of CMTM7 expression in B cells resulted in an impairment of sIgM-ligation-induced tyrosine phosphorylation of BLNK, which was due to an impaired interaction of BLNK and Syk, and in a failure to activate JNK and ERK, but not upstream kinases such as Src-family kinases and Syk.
Affiliation: Division of Molecular Biology Laboratory, Research Institute for Biological Sciences (RIBS), Tokyo University of Science, Noda, Chiba, Japan. .
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11: Title: [Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].
Authors: Li, Gang, et.al. .
Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao), Vol. 45 (8): 995-1000, 2010 .
Snippet: Testosterone did not influence the expression of CKLF1, CMTM3 and CMTM5, the CMTM6, CMTM7 and CMTM8 of CMTM family were not detected in testis tissue.
Affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .
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12: Title: Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
Authors: Morrison, Alanna C, et.al. .
Journal: Circulation. Cardiovascular genetics (Circ Cardiovasc Genet), Vol. 3 (3): 248-55, 2010 .
Snippet: Meta-analytic findings among individuals of European ancestry revealed 1 genome-wide significant locus on chromosome 3p22 in an intron of CKLF-like MARVEL transmembrane domain containing 7 (CMTM7, P=3.2x10(-7)).
Affiliation: Atherosclerosis Risk in Communities Study: University of Texas Health Science Center at Houston, Human Genetics Center, Houston, TX 77030, USA. Alanna.C.Morrison@uth.tmc.edu .
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13: Title: [Preparation and characterization of monoclonal antibodies against CMTM7].
Authors: Xu, Lan Jun, et.al. .
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao), Vol. 40 (3): 236-40, 2008 .
Snippet: Data obtained from immunofluorescence and ICC indicated that CMTM7 protein expression was upregulated in the early stage of lymphocyte activation treated with phytohemagglutinin (PHA).
Affiliation: Department of Immunology, Peking University School of Basic Medical Sciences, Beijing, China. .
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14: Title: Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.
Authors: Sugimoto, Naoshi, et.al. .
Journal: International immunology (Int Immunol), Vol. 18 (8): 1197-209, 2006 .
Snippet: We found that the Gpr83, Ecm1, Cmtm7, Nkg7, Socs2 and glutaredoxin genes are predominantly transcribed in fresh and activated natural Treg as well as in Foxp3-transduced cells, while insulin-like 7, galectin-1, granzyme B and helios genes are natural Treg specific but Foxp3 independent.
Affiliation: Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. .
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