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36 documents found
1: Title: Exome Sequencing of Extended Families with Alzheimer's Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function.
Authors: Cukier, H N, et.al. .
Journal: Journal of Alzheimer's disease & Parkinsonism (J Alzheimers Dis Parkinsonism), Vol. 7 (4), 2017 .
Snippet: Genes with segregating alterations in these peaks include CD163L1 and CLECL1, two genes that have both been implicated in immunity, CTNNA1, which encodes a catenin in the cerebral cortex and MIEF1, a gene that may induce mitochondrial dysfunction and has the potential to damage neurons.
Affiliation: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. John T. Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA. Mental Health and Behavioral Sciences Service, Miami Veterans Affairs, Miami, FL, USA. Departments of Medicine, Neurology, Ophthalmology, Genetics and Genomics, Epidemiology and Biostatistics, Boston University, Boston, MA, USA. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. .
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2: Title: Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins.
Authors: Kawaai, Katsuhiro, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (15): 3921-3926, 2017 .
Snippet: IRBIT [inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with inositol 1,4,5-trisphosphate (IP3)] is a multifunctional protein that regulates several target molecules such as ion channels, transporters, polyadenylation complex, and kinases.
Affiliation: Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan. Department of Internal Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan; mikosiba@brain.riken.jp. .
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3: Title: Cyclic AMP Recruits a Discrete Intracellular Ca(2+) Store by Unmasking Hypersensitive IP3 Receptors.
Authors: Konieczny, Vera, et.al. .
Journal: Cell reports (Cell Rep), Vol. 18 (3): 711-722, 2017 .
Snippet: We investigated this interaction in HEK293 cells using carbachol and parathyroid hormone (PTH) to stimulate formation of IP3 and cAMP, respectively.
Affiliation: Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK. Electronic address: cwt1000@cam.ac.uk. .
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4: Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.
Authors: Bonneau, Benjamin, et.al. .
Journal: eLife, Vol. 5, 2016 .
Snippet: IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.
Affiliation: Laboratory for Developmental Neurobiology, RIKEN Brain Science institute, Wako-shi, Japan. Department of Anatomy, School of Medicine Hokkaido University, Sapporo, Japan. .
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5: Title: Combining Unique Multiplex Gateway Cloning and Bimolecular Fluorescence Complementation (BiFC) for High-Throughput Screening of Protein-Protein Interactions.
Authors: Lepur, Adriana, et.al. .
Journal: Journal of biomolecular screening (J Biomol Screen), Vol. 21 (10): 1100-1111, 2016 .
Snippet: This offers a platform to rapidly identify and localize new protein interactions inside living cells, a prerequisite to validate in silico interactome data, and ultimately decode complex protein networks.
Affiliation: 1 Department for Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia. .
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6: Title: Mutations in the IRBIT domain of ITPR1 are a frequent cause of autosomal dominant nonprogressive congenital ataxia.
Authors: Barresi, S, et.al. .
Journal: Clinical genetics (Clin Genet), Vol. 91 (1): 86-91, 2017 .
Snippet: Novel pathological mutations of ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) were found in seven patients from four families (4/24, ∼16.8%) all localized in the IRBIT (inositol triphosphate receptor binding protein) domain which plays an essential role in the regulation of neuronal plasticity and development.
Affiliation: Department of Neurosciences, Unit of Molecular Medicine for Neuromuscular and Neurodegenerative Disorders, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Genetics and Rare Diseases Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Department of Neurosciences, Child Neuropsychiatry, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Clinic for Child Neurology and Psychiatry, Medical Faculty, University of Belgrade, Belgrade, Serbia. Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Centro ambulatoriale di Riabilitazione, Fondazione Betania Onlus, Catanzaro, Italy. Department of Neurosciences, Neurology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. .
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7: Title: IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.
Authors: Ando, Hideaki, et.al. .
Journal: PloS one, Vol. 10 (10): e0141569, 2015 .
Snippet: Phosphatidylinositol phosphate kinases (PIPKs) are lipid kinases that generate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a critical lipid signaling molecule that regulates diverse cellular functions, including the activities of membrane channels and transporters.
Affiliation: Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama, Japan. Division of Biochemistry, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe, Hyogo, Japan. .
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8: Title: Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss.
Authors: He, Peijian, et.al. .
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 125 (9): 3519-31, 2015 .
Snippet: We found that the expression of Na+/H+ exchanger NHE3 and several scaffold proteins, including NHE3 regulatory factors (NHERFs), inositol trisphosphate (IP₃) receptor-binding protein released with IP₃ (IRBIT), and ezrin, was decreased in the intestinal brush border membrane (BBM) of mice with streptozotocin-induced diabetes.
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9: Title: C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity.
Authors: Wiersma, Valerie R, et.al. .
Journal: mAbs, Vol. 7 (2): 321-30, 2015 .
Snippet: Here, we report that targeted delivery of the tumoricidal protein tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to granulocyte marker C-type lectin-like molecule-1 (CLL1), using fusion protein CLL1:TRAIL, equips granulocytes with high levels of TRAIL.
Affiliation: a University of Groningen; University Medical Center Groningen (UMCG) ; Department of Surgery; Translational Surgical Oncology ; Groningen , The Netherlands. .
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10: Title: Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
Authors: Copik, Alicja J, et.al. .
Journal: PloS one, Vol. 10 (1): e0115701, 2015 .
Snippet: The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid formation and MAPK pathways.
Affiliation: Biochemical Pharmacology, Inflammation Discovery, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America. Nephrology Division, Department of Medicine, Medical University of South Carolina, and Medical and Research Services, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29425, United States of America. Discovery Technologies, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America. .
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11: Title: Role of IP3 receptor signaling in cell functions and diseases.
Journal: Advances in biological regulation (Adv Biol Regul), Vol. 57, 2015 .
Snippet: Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.
Affiliation: Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, Japan. Electronic address: mikosiba@brain.riken.jp. .
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12: Title: IRBIT promotes allosteric inhibition of ribonucleotide reductase.
Journal: Cancer discovery (Cancer Discov), Vol. 4 (11): 1255, 2014 .
Snippet: IRBIT inhibits ribonucleotide reductase (RNR) by stabilizing dATP binding to the RNR activity site.
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13: Title: Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes.
Authors: Arnaoutov, Alexei, et.al. .
Journal: Science (New York, N.Y.) (Science), Vol. 345 (6203): 1512-5, 2014 .
Snippet: Ribonucleotide reductase (RNR) supplies the balanced pools of deoxynucleotide triphosphates (dNTPs) necessary for DNA replication and maintenance of genomic integrity.
Affiliation: Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. arnaouta@mail.nih.gov. Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. .
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14: Title: IRBIT: a regulator of ion channels and ion transporters.
Authors: Ando, Hideaki, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1843 (10): 2195-204, 2014 .
Snippet: Unexpectedly, many functions have subsequently been identified for IRBIT including the activation of multiple ion channels and ion transporters, such as the Na(+)/HCO3(-) co-transporter NBCe1-B, the Na(+)/H(+) exchanger NHE3, the Cl(-) channel cystic fibrosis transmembrane conductance regulator (CFTR), and the Cl(-)/HCO3(-) exchanger Slc26a6.
Affiliation: Laboratories for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan. Laboratories for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan. Electronic address: mikosiba@brain.riken.jp. .
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15: Title: The complement anaphylatoxin receptors are not required for the development of experimental autoimmune uveitis.
Authors: Read, Russell W, et.al. .
Journal: Journal of neuroimmunology (J Neuroimmunol), Vol. 264 (1-2): 127-9, 2013 .
Snippet: To determine if complement anaphylatoxin-mediated inflammation contributes to the development and progression of experimental autoimmune uveitis (EAU), we induced disease in wild type and complement anaphylatoxin receptor-deficient mice (C3a receptor(-/-), C5a receptor(-/-) and C3aR(-/-)/C5aR(-/-)) and evaluated the eyes three weeks post-induction.
Affiliation: Department of Ophthalmology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA; Department of Pathology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA; Department of Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA. Electronic address: rwr@uab.edu. .
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16: Title: IRBIT plays an important role in NHE3-mediated pHi regulation in HSG cells.
Authors: Tran, Tien Manh, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 437 (1): 18-22, 2013 .
Snippet: Western blot and co-immunoprecipitation (CO-IP) assays were also performed, showing that NHE1, 2 and 3 are expressed, and IRBIT binds to NHE3.
Affiliation: Department of Physiology, School of Dentistry, Seoul National University and Dental Research Institute, Yeongeondong 28, Chongnoku, Seoul 110-749, Republic of Korea. .
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17: Title: Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na+-HCO3- cotransporters family.
Authors: Hong, Jeong Hee, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 110 (10): 4105-10, 2013 .
Snippet: HCO3(-) secretion is highly regulated, with the WNK/SPAK kinase pathway setting the resting state and the IRBIT/PP1 pathway setting the stimulated state.
Affiliation: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. .
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18: Title: The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport.
Authors: Park, Seonghee, et.al. .
Journal: Physiology (Bethesda, Md.) (Physiology (bethesda)), Vol. 27 (5): 291-9, 2012 .
Snippet: Since many transporters involved in fluid and electrolyte homeostasis are affected by PP1 and/or calcineurin, it is possible that WNK/SPAK and IRBIT/PP1 form a common regulatory pathway to tune the activity of fluid and electrolyte transport in response to physiological demands.
Affiliation: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, Maryland, USA. .
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19: Title: ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT.
Authors: Bauer, Peter O, et.al. .
Journal: Molecular neurodegeneration (Mol Neurodegener), Vol. 7, 2012 .
Snippet: BACKGROUND: Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract.
Affiliation: Laboratory for Structural Neuropathology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. .
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20: Title: IRBIT reduces the apparent affinity for intracellular Mg²⁺ in inhibition of the electrogenic Na⁺-HCO₃⁻ cotransporter NBCe1-B.
Authors: Yamaguchi, Soichiro, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 424 (3): 433-8, 2012 .
Snippet: RT-PCR, Western blot and immunofluorescence confocal microscopy revealed that IRBIT was not only expressed in the cytosol, but also colocalized with NBCe1-B in the region of plasma membranes of BPA cells.
Affiliation: Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. .
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