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26 documents found
1: Title: Displaying Tetra-Membrane Spanning Claudins on Enveloped Virus-Like Particles for Cancer Immunotherapy.
Authors: Schneider, Irene C, et.al. .
Journal: Biotechnology journal (Biotechnol J), 2017 .
Snippet: VLPs presenting CLDN6 or CLDN9 derived from different donor species were produced and preservation of their native confirmation was demonstrated by antibody binding assays.
Affiliation: Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany. Faculty of Applied Natural Sciences, TH Köln, University of Applied Sciences Cologne, Leverkusen, Germany. BioNTech Protein Therapeutics GmbH, Mainz, Germany. .
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2: Title: TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.
Journal: Immunobiology, Vol. 223 (1): 38-48, 2018 .
Snippet: Immunofluorescence using AGS monolayers corroborated the double phase TLR2 expression mainly on the cell membrane but a detectable signal was also determined in the cytoplasm of the cells.
Affiliation: Laboratorio de Inmunobiología, Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico. Laboratorio de Inmunobiología, Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico. Electronic address: erendon@unam.mx. .
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3: Title: Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology.
Authors: Miousse, Isabelle R, et.al. .
Journal: Genes & nutrition (Genes Nutr), Vol. 12, 2017 .
Snippet: MSD has also caused small bowel bacteria colonization, increased the abundance of pathogenic bacterial species Burkholderiales and decreased the gene expression of the intestinal transmembrane proteins-Cldn8 (0.18-fold, p < 0.05), Cldn9 (0.24-fold, p < 0.01) and Cldn10 (0.05-fold, p < 0.05).
Affiliation: Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, 4301 W. Markham Str., Slot 820-11, Little Rock, AR 72205-7199 USA. Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA. Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR USA. Department of Biochemistry, University of Arkansas for Medical Sciences, Little Rock, AR USA. Department of Health and Kinesiology, Center for Translational Research on Aging and Longevity, Texas A&M University, College Station, TX USA. .
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4: Title: Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape.
Authors: Colpitts, Che C, et.al. .
Journal: Gut, 2017 .
Snippet: However, genotype-dependent escape via CLDN6 and CLDN9 has been described in some cell lines as a possible limitation facing CLDN1-targeted therapies.
Affiliation: Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France. University of Strasbourg, Strasbourg, France. Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. .
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5: Title: NDRG1 is important to maintain the integrity of airway epithelial barrier through claudin-9 expression.
Authors: Gon, Yasuhiro, et.al. .
Journal: Cell biology international (Cell Biol Int), Vol. 41 (7): 716-725, 2017 .
Snippet: Microarray analyses were conducted using the Affimetrix human whole genome gene chip, and we identified the N-myc downstream-regulated gene 1 (NDRG1) gene, which was induced during the development of the epithelial cell barrier.
Affiliation: Division of Respiratory Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-Kamicho, Itabashiku, Tokyo 173-8610, Japan. Division of Otolaryngology, Nihon University School of Medicine, 30-1 Ohyaguchi-Kamicho, Itabashiku, Tokyo 173-8610, Japan. Division of Microbiology, Nihon University School of Medicine, 30-1 Ohyaguchi-Kamicho, Itabashiku, Tokyo 173-8610, Japan. .
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6: Title: Tongxinluo Reverses the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells.
Authors: Liu, Kun, et.al. .
Journal: Chinese medical journal (Chinese Med J-peking), Vol. 129 (4): 442-7, 2016 .
Snippet: BACKGROUND: Claudin-5, claudin-9, and claudin-11 are expressed in endothelial cells to constitute tight junctions, and their deficiency may lead to hyperpermeability, which is the initiating process and pathological basis of cardiovascular disease.
Affiliation: Department of Biochemistry, Hebei Key Laboratory of Medical Biotechnology, Hebei Medical University, Shijiazhuang, Hebei 050017, China. .
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7: Title: A spontaneous metastasis model reveals the significance of claudin-9 overexpression in lung cancer metastasis.
Authors: Sharma, Rajesh K, et.al. .
Journal: Clinical & experimental metastasis (Clin Exp Metastasis), Vol. 33 (3): 263-75, 2016 .
Snippet: Microarray analysis of 3LL and p-3LL cells as well as the primary tumors derived from these cells revealed altered expression of several genes including significant upregulation of a tight junction protein, claudin-9.
Affiliation: James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA. rkshar01@louisville.edu. Department of Medicine, University of Louisville, Louisville, KY, 40202, USA. rkshar01@louisville.edu. Department of Microbiology and Immunology, University of Louisville, Louisville, KY, 40202, USA. rkshar01@louisville.edu. Department of Microbiology and Immunology, University of Louisville, Louisville, KY, 40202, USA. James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA. The Hiram C. Polk Jr, MD, Department of Surgery, University of Louisville, Louisville, KY, 40202, USA. James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA. h0bodd01@louisville.edu. Department of Microbiology and Immunology, University of Louisville, Louisville, KY, 40202, USA. h0bodd01@louisville.edu. .
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8: Title: Identification of Variants of Hepatitis C Virus (HCV) Entry Factors in Patients Highly Exposed to HCV but Remaining Uninfected: An ANRS Case-Control Study.
Authors: Fouquet, Baptiste, et.al. .
Journal: PloS one, Vol. 10 (11): e0142698, 2015 .
Snippet: Here we performed direct genomic sequencing of the Claudin-6, Claudin-9, Occludin and Scavenger receptor-B1 (SCARB1) gene coding regions.
Affiliation: Univ Paris Sud, Faculté de Médecine, Hôpitaux Universitaires Paris Sud, Hopital Bicetre, 94275, Le Kremlin-Bicêtre, France. APHP, Unité Fonctionnelle de Thérapeutique en Immuno-Infectiologie, Hôpitaux Universitaire Paris Centre, Hôpital Hôtel Dieu, Paris, France. Université Paris Descartes, EA 7327, Faculté de Médecine site Necker, Sorbonne Paris Cité, Paris, France. APHP, Service de Médecine Interne, Hôpitaux Universitaires Paris Sud, Hôpital Bicêtre, 94275, Le Kremlin-Bicêtre, France. APHP, Service de Médecine Interne, Hôpitaux Universitaires Paris Centre, Hôpital Cochin, Paris, France. APHP, Service des Maladies Infectieuses et Tropicales, Hôpitaux Universitaires Paris Nord val de Seine, Hospitalier Bichat-Claude Bernard, Paris, France. Centre Médical de l'Institut Pasteur, 75015, Paris, France. .
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9: Title: Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues.
Authors: Zhu, Jianyou, et.al. .
Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol), Vol. 8 (8): 9479-86, 2015 .
Snippet: Thus in our study, the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.
Affiliation: Department of Pathology, People's Hospital of Linzi District, Affiliated to Binzhou Medical College Zibo, Shandong Province, China. Department of Clinical Laboratory, People's Hospital of Linzi District, Affiliated to Binzhou Medical College Zibo, Shandong Province, China. .
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10: Title: Selection of a hepatitis C virus with altered entry factor requirements reveals a genetic interaction between the E1 glycoprotein and claudins.
Authors: Hopcraft, Sharon E, et.al. .
Journal: Hepatology (Baltimore, Md.) (Hepatology), Vol. 62 (4): 1059-69, 2015 .
Snippet: Indeed, CLDN1/CLDN6 double-KO Huh-7.5 cells supported infection by the mutant virus only when CLDN1, CLDN6, or CLDN9 was expressed.
Affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY. .
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11: Title: Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.
Authors: Hong, Lichuan, et.al. .
Journal: Human pathology (Hum Pathol), Vol. 45 (12): 2423-9, 2014 .
Snippet: The most significantly altered gene, claudin-9 (CLDN9), was further confirmed by quantitative real-time polymerase chain reaction, Western blot, and immunohistochemical staining in 10 invasive pituitary oncocytoma samples and 10 noninvasive pituitary oncocytoma samples.
Affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, People's Republic of China; School of Medicine, Tsinghua University, Beijing 100084, People's Republic of China. Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, People's Republic of China; Department of Neurosurgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, People's Republic of China. Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, People's Republic of China. Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, People's Republic of China. Electronic address: zyz_2004520@yeah.net. .
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12: Title: Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
Authors: Fofana, Isabel, et.al. .
Journal: Journal of virology (J Virol), Vol. 87 (18): 10405-10, 2013 .
Snippet: We produced claudin-6- or claudin-9-specific monoclonal antibodies that inhibit HCV entry into nonhepatic cells expressing exogenous claudin-6 or claudin-9.
Affiliation: Inserm, U1110, Strasbourg, France. .
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13: Title: Isolate-dependent use of claudins for cell entry by hepatitis C virus.
Authors: Haid, Sibylle, et.al. .
Journal: Hepatology (Baltimore, Md.) (Hepatology), Vol. 59 (1): 24-34, 2014 .
Snippet: In addition, CLDN6 and CLDN9 have been shown to substitute for CLDN1 as HCV entry factors in human nonliver cells.
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14: Title: Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk.
Authors: Park, Sue K, et.al. .
Journal: PloS one, Vol. 7 (9): e45274, 2012 .
Snippet: Six significant SNPs in four innate immunity (DEFA6, DEFB1, JAK3, and ACAA1) and 11 SNPs in nine NHL-related genes (INSL3, CHMP7, BCL2L11, TNFRSF8, RAD50, CASP7, CHUK, CD79B, and CLDN9) with a permutated p-value <0.01 were re-genotyped in the Replication phase among 386 cases and 348 controls.
Affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. .
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15: Title: The mRNA of claudins is expressed in the endolymphatic sac epithelia.
Authors: Matsubara, Ai, et.al. .
Journal: Auris, nasus, larynx (Auris Nasus Larynx), Vol. 39 (4): 361-4, 2012 .
Snippet: RESULTS: RT-PCR indicated the expression of cldn2, cldn4, cldn6, cldn7, cldn9, cldn11, cldn12, and cldn14.
Affiliation: Department of Otolaryngology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. aimatsu@med.kagawa-u.ac.jp .
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16: Title: Characterization and evaluation of the antitumour activity of a dual-targeting monoclonal antibody against claudin-3 and claudin-4.
Authors: Kato-Nakano, Mariko, et.al. .
Journal: Anticancer research (Anticancer Res), Vol. 30 (11): 4555-62, 2010 .
Snippet: RESULTS: A monoclonal antibody, KM3907 (IgG2a), which recognised CLDN3 and CLDN4, but not CLDN5, CLDN6 and CLDN9, was successfully isolated.
Affiliation: Antibody Research Laboratories, Kyowa Hakko Kirin Co Ltd, Tokyo, Japan. .
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17: Title: Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate.
Journal: Cancer investigation (Cancer Invest), Vol. 29 (1): 1-11, 2011 .
Snippet: We analyzed if the overexpression of claudin-6, claudin-7, or claudin-9 in AGS cells altered cell motility, invasiveness, or proliferation rate.
Affiliation: Depto. Bioquímica, Facultad de Medicina, UNAM, México. .
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18: Title: Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas.
Authors: Rendón-Huerta, Erika, et.al. .
Journal: Journal of gastrointestinal cancer (J Gastrointest Cancer), Vol. 41 (1): 52-9, 2010 .
Snippet: METHODS: Fifty paraffin-embedded tissue blocks of diffuse- and intestinal-type gastric adenocarcinomas and fresh gastric biopsies obtained endoscopically from 20 patients with a presumptive diagnosis of gastric cancer were analyzed.
Affiliation: Depto Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, México. .
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19: Title: A claudin-9-based ion permeability barrier is essential for hearing.
Authors: Nakano, Yoko, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 5 (8): e1000610, 2009 .
Snippet: In an epithelial cell line, heterologous expression of wild-type claudin-9 reduced the paracellular permeability to Na+ and K+, and the nmf329 mutation eliminated this ion barrier function without affecting the plasma membrane localization of claudin-9.
Affiliation: Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA. .
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20: Title: Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.
Authors: Sas, David, et.al. .
Journal: American journal of physiology. Regulatory, integrative and comparative physiology (Am J Physiol-reg I), Vol. 295 (5): R1713-9, 2008 .
Snippet: The neonatal proximal tubule has a lower permeability to chloride, higher resistance, and higher relative sodium-to-chloride permeability (P(Na)/P(Cl)) than the adult tubule, which may be due to maturational changes in the tight junction.
Affiliation: Dept. of Pediatrics, U.T. Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235, USA. .
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