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15 documents found
1: Title: Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
Authors: Sun, Jian, et.al. .
Journal: Oncotarget, Vol. 8 (7): 11489-11506, 2017 .
Snippet: Moreover, CHRDL2 promoted CRC cell proliferation in vitro and in vivo, perhaps through up-regulation of Cyclin D1 and down-regulation of P21.
Affiliation: Interventional Cancer Institute of Integrative Medicine & Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China. Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Cancer Institute of Traditional Chinese Medicine & Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
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2: Title: Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damage.
Authors: Seiler, Kristen M, et.al. .
Journal: Cell and tissue research (Cell Tissue Res), Vol. 361 (2): 427-38, 2015 .
Snippet: Of these, the epidermal growth factor (EGF) family member amphiregulin and the BMP antagonist chordin-like 2 were chosen for further study.
Affiliation: Department of Medicine and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 4341 Medical Biomolecular Research Building (MBRB), CB# 7032, Chapel Hill, NC, 27599-7032, USA. .
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3: Title: Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.
Authors: Chou, C-H, et.al. .
Journal: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society (Osteoarthritis Cartilage), Vol. 23 (4): 571-80, 2015 .
Snippet: Up-regulated expression of IL11, POSTN, TNFAIP6, and down-regulated expression of CHRDL2, MATN4, SPOCK3, VIT, PDE3B were significantly associated with OA progression and validated in both medial and lateral compartment dominant OA samples.
Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; National Center for Genome Medicine, Academia Sinica, Taipei, Taiwan; Department of Pathology, Duke University School of Medicine, Durham, NC, USA. Electronic address: cc380@duke.edu. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; National Center for Genome Medicine, Academia Sinica, Taipei, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan; Laboratory for International Alliance, RIKEN Center for Genomic Medicine, Yokohama, Japan. Electronic address: mikelee@src.riken.jp. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; National Center for Genome Medicine, Academia Sinica, Taipei, Taiwan; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. Electronic address: iwsong16@yahoo.com.tw. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; National Center for Genome Medicine, Academia Sinica, Taipei, Taiwan. Electronic address: liangsuei@gmail.com. Department of Orthopaedic Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: doc20231@gmail.com. Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Orthopedics, Taipei Medical University Hospital, Taiwan. Electronic address: chianherlee@yahoo.com.tw. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; National Center for Genome Medicine, Academia Sinica, Taipei, Taiwan; Translational Resource Center for Genomic Medicine, Academia Sinica, Taipei, Taiwan. Electronic address: jywu@ibms.sinica.edu.tw. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. Electronic address: chen0010@ibms.sinica.edu.tw. Duke Molecular Physiology Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Department of Pathology, Duke University School of Medicine, Durham, NC, USA. Electronic address: vbk@duke.edu. Department of Orthopaedic Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: doc20281@gmail.com. .
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4: Title: Transcriptome analysis of the dihydrotestosterone-exposed fetal rat gubernaculum identifies common androgen and insulin-like 3 targets.
Authors: Barthold, Julia S, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 89 (6): 143, 2013 .
Snippet: The qRT-PCR results confirmed that DHT increased expression of the INSL3-responsive genes Crlf1 and Chrdl2 but reduced expression of Wnt4.
Affiliation: Nemours Biomedical Research/Alfred I. duPont Hospital for Children, Wilmington, Delaware. .
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5: Title: Molecular characterization of central neurocytomas: potential markers for tumor typing and progression.
Authors: Vasiljevic, Alexandre, et.al. .
Journal: Neuropathology : official journal of the Japanese Society of Neuropathology (Neuropathology), Vol. 33 (2): 149-61, 2013 .
Snippet: The overexpression of eight candidate genes in CNs (CHRDL2, IGF2, KiSS-1, CAL2, NTS, NHLH1, RGS16 and SCGN) was confirmed by real-time RT-PCR.
Affiliation: Department of Pathology and Neuropathology, Groupement Hospitalier Est, Bron, France. .
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6: Title: Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair.
Authors: Macsai, Carmen E, et.al. .
Journal: Bone, Vol. 50 (5): 1081-91, 2012 .
Snippet: Four major functional groupings of differentially expressed genes with known roles in skeletal development were identified across the time-course of bone bridge formation, including Wnt signalling (SFRP1, SFRP4, β-catenin, Csnk2a1, Tcf7, Lef1, Fzd1, Fzd2, Wisp1 and Cpz), BMP signalling (BMP-2, BMP-6, BMP-7, Chrd, Chrdl2 and Id1), osteoblast differentiation (BMP-2, BMP-6, Chrd, Hgn, Spp1, Axin2, β-catenin, Bglap2) and skeletal development (Chrd, Mmp9, BMP-1, BMP-6, Spp1, Fgfr1 and Traf6).
Affiliation: Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia. .
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7: Title: Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways.
Authors: Johnson, Kamin J, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 83 (5): 774-82, 2010 .
Snippet: Using quantitative RT-PCR, the microarray data were confirmed, and the induction of Bmp3, Chrdl2, Crlf1, Nptx2, Pnoc, Wnt4, and Wnt5a mRNA levels were examined over a range of INSL3 concentrations (0.1-100 nM) in male and female gubernaculum.
Affiliation: Nemours Biomedical Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19803, USA. johnson@medsci.udel.edu .
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8: Title: Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis.
Authors: Branam, Amanda M, et.al. .
Journal: Developmental biology (Dev Biol), Vol. 341 (2): 444-58, 2010 .
Snippet: Chl, like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1; loss-of-function experiments show Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.
Affiliation: Molecular and Cellular Pharmacology Program, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA. .
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9: Title: The binding of von Willebrand factor type C domains of Chordin family proteins to BMP-2 and Tsg is mediated by their SD1 subdomain.
Authors: Fujisawa, Takuo, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 385 (2): 215-9, 2009 .
Snippet: Mutational analysis revealed similar binding epitopes of the various SD1 proteins for BMP-2 and Tsg.
Affiliation: Department of Physiological Chemistry II, University of Wuerzburg, Am Hubland, Wuerzburg, Germany. .
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10: Title: Candidate genes responsible for common and different pathology of infected muscle tissues between Trichinella spiralis and T. pseudospiralis infection.
Authors: Wu, Zhiliang, et.al. .
Journal: Parasitology international (Parasitol Int), Vol. 57 (3): 368-78, 2008 .
Snippet: Many of these differentially expressed genes were associated with satellite cell activation and proliferation (paired box gene 7, Pax7; Pax3; desmin; M-cadherin), myogenesis and muscle development (eyes absent 2 homolog, Eya2; myocyte enhancer factor 2C, MEF2C; pre B-cell leukemia transcription factor 1, Pbx1; chordin-like 2, Chrdl2), cell differentiation (galectin 1; insulin like growth factors, IGFs; c-ski; msh-like 1, Msx1; Numb), cell proliferation and cycle regulation (retinoblastoma 1, Rb1; granulin; p21, CDK4, cyclin A2), and apoptosis (tumor necrosis factor receptor 1, TNF-R1; programmed cell death protein 11, Pdcd11; Pdcd1; nuclear protein 1, Nuprl; clusterin, CLU).
Affiliation: Department of Parasitology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, Japan. wu@gifu-u.ac.jp .
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11: Title: Laser capture-microarray analysis of Lim1 mutant kidney development.
Authors: Potter, S Steven, et.al. .
Journal: Genesis (New York, N.Y. : 2000) (Genesis), Vol. 45 (7): 432-9, 2007 .
Snippet: Among the genes found differently expressed were Chrdl2, an inhibitor of BMP signaling, the proapoptotic factor Bmf, as well as myob5, an atypical myosin that modulates chemokine signaling, and pdgfrl, which is important in epithelial folding.
Affiliation: Division of Developmental Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. steve.potter@cchmc.org .
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12: Title: von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms.
Authors: Zhang, Jin-Li, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 282 (27): 20002-14, 2007 .
Snippet: A stable ternary complex consisting of BMP-2, CHL2, and Tsg can be formed, thus making CHL2 a more efficient BMP-2 inhibitor.
Affiliation: Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. zhang@biozentrum.uni-wuerzburg.de .
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13: Title: hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.
Authors: Oren, Anat, et.al. .
Journal: Gene, Vol. 331, 2004 .
Snippet: Differential expression of CHL2 variants was observed during myoblast and osteoblast differentiation, implying a role for this gene in these physiological processes.
Affiliation: Compugen Ltd., 72 Pinchas Rosen St., Tel Aviv 69512, Israel. .
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14: Title: A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.
Authors: Nakayama, Naoki, et.al. .
Journal: Development (Cambridge, England) (Development), Vol. 131 (1): 229-40, 2004 .
Snippet: CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs
Affiliation: Department of Metabolic Disorders, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, USA. naoki.nakayama@petermac.org .
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15: Title: BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues.
Authors: Wu, Inmin, et.al. .
Journal: Gene, Vol. 311, 2003 .
Snippet: The mature protein of this gene contains cysteine-rich repeats that are a specific feature of several extracellular matrix proteins including thrombospondin-1, thrombospondin-2, pro-collagen type 1, and von Willebrand Factor 1. PCR analysis of BNF-1 expression in a variety of human adult normal tissues revealed that BNF-1 is expressed predominantly in liver, heart, prostate, testis, and ovary.
Affiliation: Laboratory for Surgical Research, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. .
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