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10 documents found
1: Title: The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.
Authors: Fusella, Federica, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8 (1): 1636, 2017 .
Snippet: Here we show that NF-κB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana, a previously unknown component of the IKK complex and essential for IκBα substrate recognition.
Affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, 10126, Italy. federica.fusella@unito.it. Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, 10126, Italy. Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, 10123, Italy. Human Genetics Foundation (HuGeF), Via Nizza 52, Torino, 10126, Italy. Department of Medical Sciences, University of Torino, Torino, 10126, Italy. Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia, Biella, 13900, Italy. Centre for Biological Sciences, Central University of Bihar, Patna Campus, Bihar, 800014, India. Department of Clinical and Biological Sciences, University of Torino, Orbassano, 10043, Italy. Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, 20132, Italy. Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, 10126, Italy. mara.brancaccio@unito.it. .
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2: Title: Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.
Authors: Ong, Jennie, et.al. .
Journal: PloS one, Vol. 12 (9): e0183815, 2017 .
Snippet: The miR-455-3p target genes HN1, NGF, STRADB, DLD and ANO3 and the miR-21-3p target genes HHEX, CHORDC1 and ZBTB49 were consistently more enriched after TGF-β1 stimulation.
Affiliation: University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands. University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands. Boston University, School of Medicine, Department of Medicine, Section of Computational Biomedicine, Boston, Massachusetts, United States of America. University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands. .
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3: Title: C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.
Authors: Marneth, A E, et.al. .
Journal: Leukemia, 2017 .
Snippet: C-terminal BRE might be an important contributor to this program because in a case with relapsed AML, we observed an ins(11;2) fusing CHORDC1 to BRE at the region where intragenic transcription starts in KMT2A-rearranged and KAT6A-CREBBP AML.Leukemia accepted article preview online, 05 September 2017.
Affiliation: Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center. Department of Molecular Biology, Faculty of Science, RIMLS, Radboud University, Nijmegen, the Netherlands. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands. Max Planck Institute for Molecular Genetics, Berlin, Germany. Department of Clinical Genetics, Erasmus University Medical Center. Pediatric Oncology/Hematology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands. Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. MLL Munich Leukemia Laboratory, Munich, Germany. .
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4: Title: The double face of Morgana in tumorigenesis.
Authors: Brancaccio, Mara, et.al. .
Journal: Oncotarget, Vol. 6 (40): 42603-12, 2015 .
Snippet: Our most recent findings demonstrated that if on the one hand low Morgana expression levels, by inducing ROCK II hyperactivation, cause centrosome overduplication and genomic instability, on the other hand, Morgana overexpression induces tumor cell survival and chemoresistance through the ROCK I-PTEN-AKT axis.
Affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. .
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5: Title: Quantitative Proteomics of Human Fibroblasts with I1061T Mutation in Niemann-Pick C1 (NPC1) Protein Provides Insights into the Disease Pathogenesis.
Authors: Rauniyar, Navin, et.al. .
Journal: Molecular & cellular proteomics : MCP (Mol Cell Proteomics), Vol. 14 (7): 1734-49, 2015 .
Snippet: The relative expression level of a subset of differentially expressed proteins (TOR4A, DHCR24, CLGN, SOD2, CHORDC1, HSPB7, and GAA) was independently and successfully substantiated by Western blotting.
Affiliation: From the ‡Department of Chemical Physiology. §Department of Cell and Molecular Biology, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California-92037. §Department of Cell and Molecular Biology, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California-92037. webalch@scripps.edu jyates@scripps.edu. From the ‡Department of Chemical Physiology, webalch@scripps.edu jyates@scripps.edu. .
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6: Title: MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein.
Authors: Zhao, Fanpeng, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (50): 35029-41, 2014 .
Snippet: These results suggest that suppression of miR-26b expression up-regulates its target gene CHORDC1, which increases HBV enhancer/promoter activities and promotes viral transcription, gene expression, and replication.
Affiliation: From the State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China. From the State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China yingzhu@whu.edu.cn. .
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7: Title: Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis.
Authors: Zhang, Chengcheng, et.al. .
Journal: Journal of biosciences (J Biosci), Vol. 39 (1): 63-74, 2014 .
Snippet: Alignment with the NCBI database revealed 16 interactive proteins: DDX5, PSMC3, NAV1, PHF5A, GNB2L1, CSDE1, HSPA8, BRMS1, PPP2R3C, AIP, TMED10, POLR1C, TMEM70, METAP2, CHORDC1 and COPS6.
Affiliation: College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi, China. .
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8: Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
Authors: Hong, Tae-Joon, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (1): 215-22, 2013 .
Snippet: Here, we report that ADP and ATP can bind to Hsp90 cochaperones Chp-1 and PP5, inducing their conformational changes.
Affiliation: School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea. .
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9: Title: A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.
Authors: Gano, Jacob J, et.al. .
Journal: Molecular & cellular proteomics : MCP (Mol Cell Proteomics), Vol. 9 (2): 255-70, 2010 .
Snippet: We further characterized a novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1.
Affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. .
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10: Title: The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development.
Authors: Gerstner, Jason R, et.al. .
Journal: Neurochemical research (Neurochem Res), Vol. 32 (2): 241-50, 2007 .
Snippet: Analysis of adult hippocampus, prefrontal cortex and cerebellum confirmed these observations and a comparison between adult and P6 animals using in situ hybridization indicated that Chordc1 underwent coordinated but altered diurnal changes in mRNA abundance during development.
Affiliation: Neuroscience Training Program and Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA. .
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