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6 documents found
1: Title: Comparative expression of hCG β-genes in human trophoblast from early and late first-trimester placentas.
Authors: Cocquebert, M, et.al. .
Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol Endocrinol Metab), Vol. 303 (8): E950-8, 2012 .
Snippet: Two specific β-hCG proteins that differ from three amino acids have been described: type 1 (CGB7) and type 2 (CGB3, -5, and -8).
Affiliation: Institut National de la Santé et de la Recherche Médicale, UMR-S 767, Paris, France. .
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2: Title: The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene.
Authors: Sohr, Sindy, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), Vol. 10 (21): 3758-67, 2011 .
Snippet: Furthermore, we describe CGB7 as a direct transcriptional target gene of p53 by identifying a p53-responsive element in the CGB7 promoter using reporter assays, electrophoretic mobility shift assays and chromatin immunoprecipitations.
Affiliation: Molecular Oncology, Medical School, University of Leipzig, Leipzig, Germany. .
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3: Title: Expression and production of human chorionic gonadotropin (hCG) in the normal secretory endometrium: evidence of CGB7 and/or CGB6 beta hCG subunit gene expression.
Authors: Zimmermann, Gerolf, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 86 (3): 87, 2012 .
Snippet: Using full-length CGB mRNA sequence analysis, we found that epithelial CGB is (co)expressed as the product of gene locus CGB7 and CGB6 (48%), as single CGB7 (42%), or to a lower percentage as single CGB6 (10%).
Affiliation: Department of Obstetrics and Gynecology, Division of Human Reproduction and Endocrinology, University of Leipzig, Leipzig, Germany. .
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4: Title: Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.
Authors: Rull, K, et.al. .
Journal: Molecular human reproduction (Mol Hum Reprod), Vol. 14 (1): 23-31, 2008 .
Snippet: HCG beta subunit is encoded by CGB, CGB5, CGB7 and CGB8 genes located at 19q13.3 in a common genome cluster with beta subunit non-coding CGB1 and CGB2.
Affiliation: Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia. .
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5: Title: Expression of beta-subunit of HCG genes during normal and failed pregnancy.
Authors: Rull, Kristiina, et.al. .
Journal: Human reproduction (Oxford, England) (Hum Reprod), Vol. 20 (12): 3360-8, 2005 .
Snippet: The receptor-binding beta-subunit of HCG (HCGbeta) is encoded by highly homologous CGB, CGB5, CGB7 and CGB8 genes.
Affiliation: Department of Obstetrics and Gynecology, University of Tartu, Estonia. Kristiina.Rull@kliinikum.ee .
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6: Title: Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays.
Authors: Giovangrandi, Y, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 168 (1): 93-100, 2001 .
Snippet: We found that the emergence of the 'trophoblastic' CGB genes in breast tumors is (i) accompanied by an increase in the total CGB mRNA steady-state level, (ii) mainly due to overexpression of genes CGB8, B5 and B3 (expression of other genes in the CGB/LHB gene cluster (CGB7, B2, B1 and LHB) changes little if at all), and (iii) not accompanied by overexpression of the CGA gene which is necessary to produce ectopic hCG heterodimeric hormone in breast tumor cells, these latter which yet expressed the LH/CG receptor.
Affiliation: Laboratoire de Génétique Moléculaire - UPRES JE 2195, Faculté des Sciences Pharmaceutiques et Biologiques de Paris, Paris, France. .
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