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28 documents found
1: Title: PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.
Authors: Malaney, Prerna, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), 2017 .
Snippet: Abbreviations AKT V-Akt Murine Thymoma Viral Oncogene CA Cancer adjacent CDK1 Cyclin dependent kinase 1 CENPC-C Centromere Protein C ChIP Chromatin Immunoprecipitation co-IP Co-immunoprecipitation COSMIC Catalog of Somatic Mutations In Cancer CREB cAMP Responsive Element Binding Protein C-tail Carboxy terminal tail E2F1 E2F Transcription Factor 1 ECIS Electric Cell-substrate Impedance Sensing EGFR Epidermal Growth Factor Receptor GSI Gamma Secretase Inhibitor HDAC1 Histone Deacetylase 1 HP1 Heterochromatin protein 1 KAP1/TRIM28 KRAB-Associated Protein 1/Tripartite Motif Containing 28 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog MCM2 Minichromosome Maintenance Complex Component 2 miRNA micro RNA MTF1 Metal-Regulatory Transcription Factor 1 PARP Poly(ADP-Ribose) Polymerase PD-1 Programmed Cell Death 1 PD-L1 Programmed Cell Death 1 Ligand 1 PI3K Phosphatidylinositol-4,5-Bisphosphate 3-Kinase PLK Polo-like Kinase pPTEN Phosphorylated PTEN PTEN Phosphatase and Tensin Homolog deleted on chromosome ten PTM Post Translational Modification Rad51 RAD51 Recombinase Rad52 RAD52 Recombinase RPA1 Replication protein A SILAC Stable Isotope Labeling with Amino Acids in Cell Culture SRF Serum Response Factor TKI Tyrosine Kinase inhbitors TMA Tissue Microarray TOP2A DNA Topoisomerase 2A.
Affiliation: a Department of Pathology and Cell Biology , Morsani College of Medicine. b College of Pharmacy, University of South Florida , Tampa , FL 33612 , United States. c Lung Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute , Tampa , Florida 33612 , United States . .
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2: Title: Defining the Epichromatin Epitope.
Authors: Gould, Travis J, et.al. .
Journal: Nucleus (Austin, Tex.) (Nucleus), 2017 .
Snippet: The peptide sequence of the Hv3 region (heavy chain variable region 3) of the PL2-6 antibody binding site strongly resembles other nucleosome acidic patch binding proteins (especially, LANA and CENPC), supporting that the nucleosome acidic patch is included within the epichromatin epitope.
Affiliation: a Department of Physics & Astronomy , Bates College , 44 Campus Avenue, Lewiston , ME 04240 , USA. b Division of Biophysics of Macromolecules, German Cancer Research Center (DKFZ) , Im Neuenheimer Feld 580, Heidelberg 69120 , Germany . c Department of Pharmaceutical Sciences , College of Pharmacy, University of New England , 716 Stevens Avenue, Portland , ME 04103 , USA. .
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3: Title: Targeting of Arabidopsis KNL2 to Centromeres Depends on the Conserved CENPC-k Motif in Its C Terminus.
Authors: Sandmann, Michael, et.al. .
Journal: The Plant cell (Plant Cell), Vol. 29 (1): 144-155, 2017 .
Snippet: Chromatin immunoprecipitation with anti-KNL2 antibodies indicated that in vivo KNL2 is preferentially associated with the centromeric repeat pAL1 Complete deletion of the CENPC-k motif did not influence its ability to interact with DNA in vitro.
Affiliation: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, D-06466 Stadt Seeland, Germany. Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109. Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, D-06466 Stadt Seeland, Germany lermonto@ipk-gatersleben.de. .
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4: Title: Aberrant Meiotic Modulation Partially Contributes to the Lower Germination Rate of Pollen Grains in Maize (Zea mays L.) Under Low Nitrogen Supply.
Authors: Zheng, Hongyan, et.al. .
Journal: Plant & cell physiology (Plant Cell Physiol), Vol. 58 (2): 342-353, 2017 .
Snippet: The appearance of 10 bivalents in the control and low N cells at diakinesis suggested that chromosome pairing and recombination in meiosis I was not affected by low N. Further gene expression analysis revealed dramatic down-regulation of Nuclear Division Cycle 80 (Ndc80) and Regulator of Chromosome Condensation 1 (Rcc1-1) expression and up-regulation of Cell Division Cycle 20 (Cdc20-1) expression, although no significant difference in the expression level of kinetochore foundation proteins Centromeric Histone H3 (Cenh3) and Centromere Protein C (Cenpc) and cohesion regulators Recombination 8 (Rec8) and Shugoshin (Sgo1) was observed.
Affiliation: Key Laboratory of Plant-Soil Interactions of the Ministry of Education, and Department of Plant Nutrition, China Agricultural University, Beijing 100193, China. These authors contributed equally to this work. The National Maize Center, and Department of Plant Genetics and Breeding, China Agricultural University, Beijing 100193, China. .
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5: Title: CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.
Authors: Thakur, Jitendra, et.al. .
Journal: Genome research (Genome Res), Vol. 26 (9): 1178-87, 2016 .
Snippet: In contrast to the currently accepted model in which CENPT associates with H3 nucleosomes, we find that CENPT is centered over the CENPB box between two well-positioned CENPA nucleosomes on the most abundant centromeric young α-satellite dimers and interacts with the CENPB/CENPC complex.
Affiliation: Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. .
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6: Title: ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells.
Authors: Chen, Jing-Hong, et.al. .
Journal: Autophagy, Vol. 11 (2): 239-52, 2015 .
Snippet: The results indicate that TPT or CDDP activates ATM (ATM serine/threonine kinase), which phosphorylates PTEN at serine 113 and further regulates PTEN nuclear translocation in A549 and HeLa cells.
Affiliation: a State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Cancer Center; Sun Yat-sen University ; Guangzhou , China. .
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7: Title: The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts.
Authors: Krizaic, Iva, et.al. .
Journal: Nucleus (Austin, Tex.) (Nucleus), Vol. 6 (2): 133-43, 2015 .
Snippet: The centromere is the chromosomal region in which the kinetochore is assembled to orchestrate chromosome segregation.
Affiliation: a Chromosome Dynamics Group ; Molecular Oncology Program ; Spanish National Cancer Research Center (CNIO) ; Madrid , Spain. .
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8: Title: An Arabidopsis tissue-specific RNAi method for studying genes essential to mitosis.
Journal: PloS one, Vol. 7 (12): e51388, 2012 .
Snippet: Cytological analyses of the affected flower buds confirmed that CENPC knockdown causes cell cycle arrest but provided no evidence that either MAD2 or BUBR1 are required for mitosis (although both genes are required for petal growth by this assay).
Affiliation: Department of Genetics, University of Georgia, Athens, Georgia, United States of America. .
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9: Title: Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases.
Authors: Hamdouch, Khaoula, et.al. .
Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta), Vol. 412 (23-24): 2267-71, 2011 .
Snippet: Major centromere autoantigens described so far include constitutive kinetochore proteins such as CENPA, CENPB, CENPC and CENPH and facultative proteins such as CENPE, CENPF and INCENP.
Affiliation: Departamento de Biomedicina, Biotecnología y Salud Pública, Facultad de Ciencias, 11510 Puerto Real, Cádiz, Spain. .
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10: Title: DNA binding of centromere protein C (CENPC) is stabilized by single-stranded RNA.
Authors: Du, Yaqing, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 6 (2): e1000835, 2010 .
Snippet: The data suggest that centromeric RNA helps to recruit CENPC to the inner kinetochore by altering its DNA binding characteristics.
Affiliation: Department of Plant Biology, University of Georgia, Athens, Georgia, United States of America. .
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11: Title: Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.
Authors: Heeger, Sebastian, et.al. .
Journal: Genes & development (Gene Dev), Vol. 19 (17): 2041-53, 2005 .
Snippet: Characterization of its centromere localization domain revealed the presence of a diverged CENPC motif.
Affiliation: Department of Genetics, BZMB, University of Bayreuth, 95440 Bayreuth, Germany. .
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12: Title: Novel interaction partners of the TPR/MET tyrosine kinase.
Authors: Schaaf, Christian P, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 19 (2): 267-9, 2005 .
Snippet: Participation in apoptosis-regulating mechanisms through interaction with DAPK-3 and cell cycle control via binding to nuclear proteins such as CENPC and SMC-1 are possible new aspects of intracellular MET signaling.
Affiliation: Institute of Human Genetics, University Clinics of Heidelberg, Heidelberg, Germany. .
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13: Title: Adaptive evolution of centromere proteins in plants and animals.
Authors: Talbert, Paul B, et.al. .
Journal: Journal of biology (J Biol), Vol. 3 (4): 18, 2004 .
Snippet: Most plant, animal and fungal centromeres also bind a large protein, centromere protein C (CENP-C), that is characterized by a single 24 amino-acid motif (CENPC motif).
Affiliation: Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. .
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14: Title: Effects of anti-leukemia drug Harringtonine on the levels of centromere proteins and gene expression of CenpB in L1210 cells.
Authors: Liang, Qian-Jin, et.al. .
Journal: Yi chuan xue bao = Acta genetica Sinica (Yi Chuan Xue Bao), Vol. 30 (6): 521-7, 2003 .
Snippet: The ACA antibodies that recognized the 17, 80 and 140 kD proteins in L1210 cells also cross-reacted with 3 proteins with similar molecular weights which are known to be CenpA, CenpB and CenpC, respectively.
Affiliation: College of Life Sciences, Beijing Normal University, Beijing 100875, China. .
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15: Title: Partially functional Cenpa-GFP fusion protein causes increased chromosome missegregation and apoptosis during mouse embryogenesis.
Authors: Kalitsis, Paul, et.al. .
Journal: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology (Chromosome Res), Vol. 11 (4): 345-57, 2003 .
Snippet: Cenpag/g embryos assemble functional kinetochores that bind to a host of centromere-specific structural and mitotic spindle checkpoint proteins (Cenpc, BubR1, Mad2 and Zw10).
Affiliation: Murdoch Childrenś Research Institute, Royal Children's Hospital, Flemington Road, Parkville 3052, Melbourne, Victoria, Australia. .
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16: Title: Centromeric retroelements and satellites interact with maize kinetochore protein CENH3.
Authors: Zhong, Cathy Xiaoyan, et.al. .
Journal: The Plant cell (Plant Cell), Vol. 14 (11): 2825-36, 2002 .
Snippet: CENH3 is present throughout the cell cycle and colocalizes with the kinetochore protein CENPC in meiotic cells.
Affiliation: Department of Plant Biology, University of Georgia, Athens, Georgia 30602, USA. .
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17: Title: Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc.
Authors: Saxena, Alka, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 11 (19): 2319-29, 2002 .
Snippet: These results, together with our previous demonstration that PARP-1 displays an identical binding pattern with Cenpa, Cenpb and Bub3, but not Cenpc, and that all three proteins undergo significant poly(ADP-ribosyl)ation upon gamma-irradiation of cells, point to possible diverse roles of PARP-2 and PARP-1 in modulating the structure and checkpoint functions of the mammalian centromere, in particular during radiation-induced DNA damage.
Affiliation: The Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville 3052, Australia. .
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18: Title: Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.
Authors: Saxena, Alka, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 277 (30): 26921-6, 2002 .
Snippet: Immunoprecipitation and Western blot analyses demonstrate that Cenpa, Cenpb, and Bub3, but not Cenpc, interacted with PARP-1, and are poly(ADP-ribosyl)ated following induction of DNA damage.
Affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Rd., Parkville 3052, Australia. .
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19: Title: Evolutionary conservation of kinetochore protein sequences in plants.
Authors: ten Hoopen, R, et.al. .
Journal: Chromosoma, Vol. 109 (7): 482-9, 2000 .
Snippet: The cross-reactivities of antibodies against human CENPC, CENPE and CENPF, and against maize CENPCa with the centromeric regions of mitotic chromosomes of Vicia faba and/or Hordeum vulgare are shown.
Affiliation: Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, Germany. hoopen@ipk-gatersleben.de .
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20: Title: Characterization of centromere alterations in liposarcomas.
Authors: Sirvent, N, et.al. .
Journal: Genes, chromosomes & cancer (Gene Chromosome Canc), Vol. 29 (2): 117-29, 2000 .
Snippet: Our results with alpha-satellite probes and anti-CENPB antibodies confirm the lack of detectable alpha-satellite sequences in the five ALP-WDLPS supernumerary chromosomes, whereas centromeric activity was proved by the detection of kinetochores by using anti-CENPC antibodies.
Affiliation: UF Recherche Clinique 0952, CHU de Nice, Université de Nice-Sophia Antipolis, France. .
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