refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
17 documents found
1: Title: CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target.
Authors: Kalra, Rajkumar S, et.al. .
Journal: Oncogenesis, Vol. 7 (5): 39, 2018 .
Snippet: CARF (Collaborator of ARF)/CDKN2AIP was discovered as a novel ARF-binding protein.
Affiliation: Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), DAICENTER, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, 305-8565, Japan. Department of Bioengineering, College of Engineering, Hanyang University, Seongdong-gu, Seoul, Korea. Department of Bioengineering, College of Engineering, Hanyang University, Seongdong-gu, Seoul, Korea. chaeok@hanyang.ac.kr. Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), DAICENTER, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, 305-8565, Japan. s-kaul@aist.go.jp. Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), DAICENTER, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, 305-8565, Japan. renu-wadhwa@aist.go.jp. .
Related Products: order online
2: Title: CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis.
Authors: Wadhwa, Renu, et.al. .
Journal: Mechanisms of ageing and development (Mech Ageing Dev), Vol. 166, 2017 .
Snippet: CARF (Collaborator of ARF) was first identified as an ARF (Alternative Reading Frame, p14ARF)-interacting protein in a yeast two-hybrid interactive screening.
Affiliation: DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science and Technology (AIST), Central 5-41, 1-1-1 Higashi, Tsukuba, Ibaraki, 305 8565 Japan. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science and Technology (AIST), Central 5-41, 1-1-1 Higashi, Tsukuba, Ibaraki, 305 8565 Japan. Electronic address: s-kaul@aist.go.jp. .
Related Products: order online
3: Title: CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma.
Authors: Fan, Xin, et.al. .
Journal: Oncotarget, Vol. 7 (49): 80404-80414, 2016 .
Snippet: Overactivation of Ras signaling is very common in the hepatocellular carcinoma (HCC) due to its constitutive active mutation, which makes it a big challenge to target Ras signaling.
Affiliation: Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, PR China. Department of Gynecology and Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, PR China. .
Related Products: order online
4: Title: Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF.
Authors: Yu, Yue, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: We also report that CARF (Collaborator of ARF) is a new target of miR-335 that regulates its growth suppressor function by complex crosstalk with other proteins including p16(INK4A), pRB, HDM2 and p21(WAF1).
Affiliation: Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science &Technology (AIST), Tsukuba-305 8565, Japan. Graduate School of Life &Environmental Sciences, University of Tsukuba, Japan. Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) &Comparative Medicine Center, Peking Union Medical College (PUMC), China. Department of Molecular Virology, Immunology &Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA. .
Related Products: order online
5: Title: Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm.
Authors: Sato, Shigeko, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 43 (21): 10397-410, 2015 .
Snippet: Collaborator of alternative reading frame protein (CARF) associates directly with ARF, p53, and/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulates cell proliferation by forming a negative feedback loop.
Affiliation: Department of Applied Biological Science, United-graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Sanbancho 5, Chiyoda-ku, Tokyo 102-0075, Japan. Department of Applied Biological Science, United-graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Sanbancho 5, Chiyoda-ku, Tokyo 102-0075, Japan The Genome Science human resource development program, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. Department of Applied Biological Science, United-graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. La Trobe Institute for Molecular Science (LIMS) LIMS Building 1, Room 412 La Trobe University, Bundoora Victoria 3086, Australia. Department of Applied Biological Science, United-graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Sanbancho 5, Chiyoda-ku, Tokyo 102-0075, Japan The Genome Science human resource development program, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan ntakahas@cc.tuat.ac.jp. .
Related Products: order online
6: Title: CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis.
Authors: Kalra, Rajkumar S, et.al. .
Journal: Molecular oncology (Mol Oncol), Vol. 9 (9): 1877-89, 2015 .
Snippet: Collaborator of ARF (CARF), initially identified as a binding partner of ARF (Alternate Reading Frame), has been shown to activate ARF-p53 pathway by multiple ways including stabilization of ARF and p53 tumor suppressor proteins, and transcriptional repression of a p53 antagonist, HDM2.
Affiliation: DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. Electronic address: s-kaul@aist.go.jp. DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. Electronic address: renu-wadhwa@aist.go.jp. .
Related Products: order online
7: Title: Discovery of prognostic biomarkers for predicting lung cancer metastasis using microarray and survival data.
Authors: Huang, Hui-Ling, et.al. .
Journal: BMC bioinformatics, Vol. 16, 2015 .
Snippet: 1) The use of disease-free survival curves can compensate for the shortcoming of insufficient samples and greatly increase the test accuracy by 11.10%; and 2) the support vector machine with a set of 17 transcripts, such as CCL16 and CDKN2AIP, can yield a leave-one-out cross-validation accuracy of 93.59%, a test accuracy of 76.92%, a large disease-free survival area of 74.81%, and a mean survival prediction error of 3.99 months.
Affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan. hlhuang@mail.nctu.edu.tw. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. hlhuang@mail.nctu.edu.tw. Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. wuyc@vghtpe.gov.tw. Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan. sulijen@ncu.edu.tw. Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, Taiwan. woodstock_ivy@hotmail.com. Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan. phaznexus@hotmail.com. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. wenurea@yahoo.com.tw. Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan. huachinlee@g2.nctu.edu.tw. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. huachinlee@g2.nctu.edu.tw. Department of Computer Science, Tunghai University, Taichung, Taiwan. cchu@thu.edu.tw. Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan. syho@mail.nctu.edu.tw. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. syho@mail.nctu.edu.tw. .
Related Products: order online
8: Title: Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming.
Authors: Yang, Chao-Shun, et.al. .
Journal: Cell reports (Cell Rep), Vol. 8 (2): 327-37, 2014 .
Snippet: Among these non-differentially expressed genes, Dmbx1, Hnf4g, Nobox, and Asb4 are important, whereas Nfe2, Cdkn2aip, Msx3, Dbx1, Lzts1, Gtf2i, and Ankrd22 are roadblocks to reprogramming.
Affiliation: Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0762, La Jolla, CA 92093, USA. Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0762, La Jolla, CA 92093, USA. Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0762, La Jolla, CA 92093, USA. Electronic address: trana@ucsd.edu. .
Related Products: order online
9: Title: Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Authors: Cheung, Caroline T, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (26): 18258-69, 2014 .
Snippet: Our previous studies have shown that (i) CARF is up-regulated during replicative and stress-induced senescence, and its exogenous overexpression caused senescence-like growth arrest of cells, and (ii) suppression of CARF induces aneuploidy, DNA damage, and mitotic catastrophe, resulting in apoptosis via the ATR/CHK1 pathway.
Affiliation: From the Cell Proliferation Research Group and. From the Cell Proliferation Research Group and Department of Biotechnology (DBT, India)-National Institute of Advanced Industrial Science & Technology (AIST, Japan) International Laboratory for Advanced Biomedicine, Tsukuba, Ibaraki 305-8562, Japan. From the Cell Proliferation Research Group and Department of Biotechnology (DBT, India)-National Institute of Advanced Industrial Science & Technology (AIST, Japan) International Laboratory for Advanced Biomedicine, Tsukuba, Ibaraki 305-8562, Japan s-kaul@aist.go.jp. From the Cell Proliferation Research Group and Department of Biotechnology (DBT, India)-National Institute of Advanced Industrial Science & Technology (AIST, Japan) International Laboratory for Advanced Biomedicine, Tsukuba, Ibaraki 305-8562, Japan renu-wadhwa@aist.go.jp. .
Related Products: order online
10: Title: Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein.
Authors: Singh, Rumani, et.al. .
Journal: Experimental cell research (Exp Cell Res), Vol. 322 (2): 324-34, 2014 .
Snippet: Induction of G1 growth arrest and senescence by a variety of drugs was associated with increase in CARF expression at the transcriptional and translational level and was seen to correlate with increase in DNA damage response and checkpoint proteins, ATM, ATR, CHK1, CHK2, γH2AX, p53 and p21.
Affiliation: Cell Proliferation Research Group and DBT-AIST International Laboratory for Advanced Biomedicine, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. Children׳s Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia; Department of Molecular Virology, Immunology and Medical Genetics, 960 Biomedical Research Tower, The Ohio State University, Columbus, OH 43210, USA. Children׳s Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia. Cell Proliferation Research Group and DBT-AIST International Laboratory for Advanced Biomedicine, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. Electronic address: s-kaul@aist.go.jp. Cell Proliferation Research Group and DBT-AIST International Laboratory for Advanced Biomedicine, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. Electronic address: renu-wadhwa@aist.go.jp. .
Related Products: order online
11: Title: PAXT-1 Promotes XRN2 Activity by Stabilizing It through a Conserved Domain.
Authors: Miki, Takashi S, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 53 (2): 351-60, 2014 .
Snippet: This domain occurs in additional metazoan proteins and mediates interaction of human CDKN2AIP/CARF and NKRF/NRF with XRN2.
Affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address: helge.grosshans@fmi.ch. .
Related Products: order online
12: Title: Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.
Authors: Fabbri, Giulia, et.al. .
Journal: The Journal of experimental medicine (J Exp Med), Vol. 210 (11): 2273-88, 2013 .
Snippet: Richter syndrome (RS) derives from the rare transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly of the diffuse large B cell lymphoma (DLBCL) type.
Affiliation: Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, 2 Department of Pathology and Cell Biology, 3 Departments of Genetics and Development and of Microbiology and Immunology and 4 Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032. .
Related Products: order online
13: Title: Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.
Authors: Kim, Ryong Nam, et.al. .
Journal: Journal of genetics (J Genet), Vol. 91 (1): e1-e11, 2012 .
No Abstract available.
Affiliation: Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. .
Related Products: order online
14: Title: Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.
Authors: Cheung, C T, et.al. .
Journal: Cell death and differentiation (Cell Death Differ), Vol. 18 (4): 589-601, 2011 .
Snippet: Thus, we examined various cell death and survival pathways including the mitochondrial stress, ataxia telangiectasia mutated (ATM)-ATR, Ras-MAP kinase and retinoblastoma cascades.
Affiliation: National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. .
Related Products: order online
15: Title: Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves.
Authors: Widodo, Nashi, et.al. .
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences (J Gerontol A Biol Sci Med Sci), Vol. 64 (10): 1031-8, 2009 .
Snippet: In the present study, we demonstrate that a major component of i-Extract and withanone (i-Factor) protected the normal human fibroblasts against the toxicity caused by withaferin A. It increased the in vitro division potential of normal human cells that appeared to be mediated by decreased accumulation of molecular damage, downregulation of the senescence-specific beta-galactosidase activity and the senescence marker protein, p21(WAF-1), protection against oxidative damage, and induction of proteasomal activity.
Affiliation: National Institute of Advanced Industrial Science & Technology, Tsukuba, Ibaraki, Japan. .
Related Products: order online
16: Title: Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.
Authors: Yi, Chun-Hui, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 284 (2): 149-56, 2009 .
Snippet: Subsequent real-time PCR assays confirmed 16 of these targets, and 9 of these genes (ARHGAP29, CDC25A, CDKN2AIP, CX3CL1, ELF4, GNAL, KDELR1, POU4F2, and THRA) have a known role in tumorigenesis.
Affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States. .
Related Products: order online
17: Title: CARF Is a vital dual regulator of cellular senescence and apoptosis.
Authors: Hasan, Kamrul, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 284 (3): 1664-72, 2009 .
Snippet: The tumor suppressor protein, p53, is central to the pathways that monitor the stress, DNA damage repair, cell cycle, aging, and cancer.
Affiliation: National Institute of Advanced Industrial Science & Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. .
Related Products: order online
Documents per page: 20 | 50 | 100