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5 documents found
1: Title: Investigation of fusion gene expression in HCT116 cells.
Authors: Zhang, Yanmei, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 14 (6): 6962-6968, 2017 .
Snippet: CDC42SE2-KIAAO146 is a genomic fusion transcript, which originates from DNA arrangement in HCT116 cells.
Affiliation: Molecular Medical Center, Zhejiang Academy of Medical Science, Hangzhou, Zhejiang 310012, P.R. China. .
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2: Title: Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese.
Authors: Jiang, Kewei, et.al. .
Journal: Oncotarget, Vol. 6 (37): 40327-36, 2015 .
Snippet: In the combined analyses, we discovered two novel loci associated with CRC: rs12522693 at 5q23.3 (CDC42SE2-CHSY3, OR = 1.31,
Affiliation: Department of General Surgery, Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing 100044, China. Health Science Research Institute, Capital Bio Corporation, Beijing 102206, China. National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China. The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing 211166, China. Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China. Department of Surgery, Ministry of Education Key Lab of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing 100142, China. Department of Colorectal Surgery, Shanxi Cancer Hospital and Institute, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030001, China. Shanxi Branch Center, National Engineering Research Center for Beijing Biochip Technology, Taiyuan, China. Department of General Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China. Department of Biomedical Engineering, Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China. Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030001, China. Department of Anal-Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan 750004, China. The Anorectal Department, Gansu Provincial People's Hospital, Lanzhou 730000, China. The State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China. Ningxia Branch Center, National Engineering Research Center for Beijing Biochip Technology, Yinchuan 750004, China. .
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3: Title: Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells.
Authors: Wu, Xiaomei, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 27 (5): 1488-96, 2012 .
Snippet: AG490 (JAK/STAT3 inhibitor) reduced MMP-2 and MMP-9 protein levels in cells treated with leptin, while IL-6 (JAK/STAT3 stimulator) and Compound C (AMPK inhibitor) elevated MMP-2 and MMP-9 protein levels in cells treated with Acrp30.
Affiliation: International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai 200030, PR China. .
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4: Title: RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5.
Authors: Zhu, Yuan Xiao, et.al. .
Journal: Blood, Vol. 117 (14): 3847-57, 2011 .
Snippet: When suppressed, the strongest bortezomib sensitizers were the proteasome subunits PSMA5, PSMB2, PSMB3, and PSMB7 providing internal validation, but others included BAZ1B, CDK5, CDC42SE2, MDM4, NME7, RAB8B, TFE3, TNFAIP3, TNK1, TOP1, VAMP2, and YY1.
Affiliation: Division of Hematology-Oncology, Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259, USA. .
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5: Title: Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia.
Authors: Chen, Xiangning, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 15 (22): 3329-42, 2006 .
Snippet: haplotypes underlying the SPEC2/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 region are associated with schizophrenia
Affiliation: Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA. xchen@vcu.edu .
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