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218 documents found
1: Title: HIV-1 Vif's capacity to manipulate the cell cycle is species-specific.
Authors: Evans, Edward L (3rd), et.al. .
Journal: Journal of virology (J Virol), 2018 .
Snippet: Cells derived from mice and other rodents exhibit profound blocks to HIV-1 virion production reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential host factors Cyclin T1 (CCNT1) and Exportin-1 (XPO1, also known as CRM1), respectively.
Affiliation: McArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin - Madison, 1525 Linden Drive, Madison, WI 53706. McArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin - Madison, 1525 Linden Drive, Madison, WI 53706 nsherer@wisc.edu. .
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2: Title: CDK9: A key player in Cancer and Other Diseases.
Authors: Franco, Lia Carolina, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), 2017 .
Snippet: It associates mainly with Cyclin T1 and forms the Positive Transcription Elongation Factor b (p-TEFb) complex responsible for regulation of transcription elongation and mRNA maturation.
Affiliation: Escuela de Medicina, Universidad de las Americas (UDLA), Quito, Ecuador. Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, Pennsylvania, US. Departamento de Química Orgánica, Universidad de Murcia, Murcia, Spain. .
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3: Title: Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-Arginine-Rich Protein ASF/SF2.
Authors: Zhou, Jieqiong, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), Vol. 118 (11): 4020-4032, 2017 .
Snippet: ASF/SF2 promotes the production of cyclin T1b versus cyclin T1a and regulates the expression of cyclin T1-depedent genes at the transcription level.
Affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China. School of Basic Medical Sciences, Wuhan University, Wuhan, China. .
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4: Title: Development of antibody-modified chitosan nanoparticles for the targeted delivery of siRNA across the blood-brain barrier as a strategy for inhibiting HIV replication in astrocytes.
Authors: Gu, Jijin, et.al. .
Journal: Drug delivery and translational research (Drug Deliv Transl Res), Vol. 7 (4): 497-506, 2017 .
Snippet: RNAPII RNA polymerase II, TAR transactivation response RNA element, LTR long terminal repeat, Ab antibody, CS chitosan, TPP tripolyphosphate.
Affiliation: Laboratory for Drug Delivery and Biomaterials, College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Ave, Winnipeg, MB, R3E 0T5, Canada. Laboratory for Drug Delivery and Biomaterials, College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Ave, Winnipeg, MB, R3E 0T5, Canada. emmanuel_ho@umanitoba.ca. .
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5: Title: Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Authors: Cheung, Ka Lung, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 65 (6): 1068-1080.e5, 2017 .
Snippet: In parallel, Brd4 temporally controls RNA polymerase II (Pol II) processivity during transcription elongation through cyclin T1 and Cdk9 recruitment and Pol II Ser2 phosphorylation.
Affiliation: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The First Hospital and Institute of Epigenetic Medicine, Jilin University, Changchun 130061, China. The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York, NY 10016, USA. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: ming-ming.zhou@mssm.edu. .
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6: Title: Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells.
Authors: Ma, Zheng, et.al. .
Journal: Journal of visualized experiments : JoVE (J Vis Exp), 2017 .
Snippet: However, this system does not enable the purification of protein subunits that contain post-translational modifications (e.g., phosphorylation and acetylation), and the identification of novel regulatory subunits that are only present/expressed in the eukaryotic system.
Affiliation: Department of Microbiology, The University of Texas Southwestern Medical Center. Department of Microbiology, The University of Texas Southwestern Medical Center; Ivan.Dorso@utsouthwestern.edu. .
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7: Title: HTLV-1 Tax activates HIV-1 transcription in latency models.
Journal: Virology, Vol. 504, 2017 .
Snippet: Tax promotes the activation of P-TEFb, releasing CDK9 and Cyclin T1 from inactive forms, promoting transcription elongation and reactivation of latent HIV-1.
Affiliation: Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil. Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil; Universidade Federal do Triângulo Mineiro, campus Iturama, Minas Gerais, 38280-000, Brazil. Instituto Nacional de Cancer, Programa de Oncovirologia, Rio de Janeiro, Brazil. Department of Microbiology, Immunology & Tropical Medicine, The George Washington University, Washington, DC, USA. Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil. Electronic address: santana@biologia.ufrj.br. .
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8: Title: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.
Authors: Schulze-Gahmen, Ursula, et.al. .
Journal: eLife, Vol. 5, 2016 .
Snippet: The structure and functional assays collectively support an integrative structure and a bipartite binding model, wherein the TAR central loop engages the CycT1 TRM and compact core of Tat, while the TAR major groove interacts with the extended Tat ARM.
Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States. California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, United States. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States. California Institute of Quantitative Biosciences, University of California San, Francisco, San Francisco, United States. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States. Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States. Department of Chemistry, University of California, Berkeley, Berkeley, United States. .
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9: Title: Structure of a low-population binding intermediate in protein-RNA recognition.
Authors: Borkar, Aditi N, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 113 (26): 7171-6, 2016 .
Snippet: The interaction of the HIV-1 protein transactivator of transcription (Tat) and its cognate transactivation response element (TAR) RNA transactivates viral transcription and represents a paradigm for the widespread occurrence of conformational rearrangements in protein-RNA recognition.
Affiliation: Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; Department of Chemistry, University of Washington, Seattle, WA 98197-1700. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; mv245@cam.ac.uk. .
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10: Title: Quantification of the HIV transcriptional activator complex in live cells by image-based protein-protein interaction analysis.
Authors: Asamitsu, Kaori, et.al. .
Journal: Genes to cells : devoted to molecular & cellular mechanisms (Genes Cells), Vol. 21 (7): 706-16, 2016 .
Snippet: The interaction of Tat with the cellular transcription elongation factor P-TEFb (positive transcriptional elongation factor b) containing cyclin T1 (CycT1) and cyclin-dependent kinase 9 (CDK9) is critical for its activity.
Affiliation: Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan. Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan. .
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11: Title: Short Communication: The Broad-Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4(+) T Cells In Part Through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb.
Authors: Jamaluddin, Md Saha, et.al. .
Journal: AIDS research and human retroviruses (Aids Res Hum Retroviruses), Vol. 32 (2): 169-73, 2016 .
Snippet: HIV provirus transcription depends critically on the positive transcription elongation factor b (P-TEFb), whose core components are cyclin-dependent kinase 9 (CDK9) and cyclin T1.
Affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas. .
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12: Title: FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency.
Authors: Huang, Huachao, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 290 (45): 27297-310, 2015 .
Snippet: Third, the presence of SUPT16H interferes with the association of Cyclin T1 (CCNT1), a subunit of P-TEFb, with the Tat-LTR axis.
Affiliation: From the Departments of Microbiology and Immunology. the School of Arts and Sciences, University of Rochester, Rochester, New York 14627. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14642. the Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263. the Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. the Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, Massachusetts 02115, and the Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115. From the Departments of Microbiology and Immunology, Biochemistry and Biophysics, and Jian_Zhu@urmc.rochester.edu. .
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13: Title: Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.
Authors: Housden, Benjamin E, et.al. .
Journal: Science signaling (Sci Signal), Vol. 8 (393): rs9, 2015 .
Snippet: Individual knockdown of three candidate genes (mRNA-cap, Pitslre, and CycT; orthologs of RNGTT, CDK11, and CCNT1 in humans) reduced the population growth rate of Drosophila cells lacking either TSC1 or TSC2 but not that of wild-type cells.
Affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. bhousden@genetics.med.harvard.edu perrimon@receptor.med.harvard.edu. Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. bhousden@genetics.med.harvard.edu perrimon@receptor.med.harvard.edu. .
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14: Title: Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Authors: Gupta, Enna Dogra, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 37 (1): 1159-71, 2016 .
Snippet: On analyzing the messenger RNA (mRNA) expression profile of the cell cycle and apoptosis-related genes, it was observed that RNAi against PA biosynthetic genes downregulated the expression of CDK8, CCNE2, CCNH, CCNT1, CCNT2, CCNF, PCNA, CCND1, and CDK2, and upregulated the expression of E2F4, BAX, FAS, TP53, CDKN1A, BAK1, CDKN1B, ATM, GRANB, and ATR genes when compared with control-transfected cells.
Affiliation: Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India. Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India. Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India. rajam.mv@gmail.com. .
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15: Title: The miRNA miR-34a enhances HIV-1 replication by targeting PNUTS/PPP1R10, which negatively regulates HIV-1 transcriptional complex formation.
Authors: Kapoor, Richa, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 470 (3): 293-302, 2015 .
Snippet: We report for the first time that PNUTS negatively regulates HIV-1 transcription by inhibiting the assembly of core components of the transcription elongation factor P-TEFb, i.e. cyclin T1 and CDK9.
Affiliation: Laboratory of Virology, National Institute of Immunology (NII), New Delhi, India. Laboratory of Cell Death & Cell Survival, Centre for DNA Fingerprinting and Diagnostics (CDFD), Nampally, Hyderabad, India. Laboratory of Virology, National Institute of Immunology (NII), New Delhi, India akhil@nii.res.in akhil_banerjea@yahoo.com. .
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16: Title: Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study.
Authors: Jin, Hai-Xiao, et.al. .
Journal: PloS one, Vol. 10 (4): e0124673, 2015 .
Snippet: The simulations unveiled that binding of HIV-1 Tat to CDK9 not only stabilized hydrogen bonds (H-bonds) between ATP and hinge residues Asp104 and Cys106, as well as between ATP and invariant Lys48, but also facilitated the salt bridge network pertaining to the phosphorylated Thr186 at the activation loop.
Affiliation: Key Laboratory of Applied Marine Biotechnology Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, China. Department of Pharmacy, National University of Singapore, Singapore, Singapore. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, China. .
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17: Title: Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.
Authors: Kumari, Namita, et.al. .
Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother), Vol. 58 (11): 6558-71, 2014 .
Snippet: Iron chelators reduced HIV-1 Gag and Env mRNA synthesis but had no effect on HIV-1 reverse transcription.
Affiliation: Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC, USA. National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, USA. ChemBio Center, National Taras Shevchenko University, Kiev, Ukraine. Viral Immunology Section, Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC, USA snekhai@howard.edu. .
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18: Title: In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.
Authors: Chen, Runqiang, et.al. .
Journal: Immunity, Vol. 41 (2): 325-38, 2014 .
Snippet: Both screens revealed roles for the positive transcription elongation factor (P-TEFb) component Cyclin T1 (Ccnt1).
Affiliation: Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. Electronic address: shane@lji.org. Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: mpipkin@scripps.edu. .
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19: Title: A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.
Authors: Kuzmina, Alona, et.al. .
Journal: Retrovirology, Vol. 11, 2014 .
Snippet: The viral Tat protein recruits the Positive Transcription Elongation Factor b (P-TEFb) and the Super Elongation Complex (SEC) to the HIV promoter and enhances transcription by host RNA polymerase II.
Affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev, P,O, Box 653, Beer-Sheva 84105, ISRAEL. rantaube@bgu.ac.il. .
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20: Title: A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat.
Authors: Verstraete, Nina, et.al. .
Journal: Retrovirology, Vol. 11, 2014 .
Snippet: CONCLUSIONS: Single Cyclin T1 amino-acid mutations that impair Hexim1 binding are located on a groove between the two cyclin folds and define a surface overlapping the HIV-1 Tat protein binding surface.
Affiliation: Institut de Biologie de l'Ecole Normale Supérieure, Paris F-75005, France. bensaude@biologie.ens.fr. .
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