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18 documents found
1: Title: Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease.
Authors: Gäbel, Gabor, et.al. .
Journal: Journal of the American Heart Association (J Am Heart Assoc), Vol. 6 (12), 2017 .
Snippet: Two gene sets were identified, 1 set containing 5 genes linked to terminal progression, that is, positively associated with progression of larger AAA, and with rupture (HILPDA, ANGPTL4, LOX, SRPX2, FCGBP), and a second set containing 5 genes exclusively upregulated in rAAA (ADAMTS9, STC1, GFPT2, GAL3ST4, CCL4L1).
Affiliation: Department of Vascular and Endovascular Surgery, Ludwig-Maximilians-University Munich, Munich, Germany gabor.gaebel@med.uni-muenchen.de. Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Technische Universität Dresden, Dresden, Germany. Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany. Department of Vascular and Endovascular Surgery, Ludwig-Maximilians-University Munich, Munich, Germany. Department of General, Visceral, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany. Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands. Vascular and Endovascular Surgery, HELIOS Clinic Erfurt, Erfurt, Germany. .
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2: Title: Population genetics of immune-related multilocus copy number variation in Native Americans.
Authors: Zuccherato, Luciana W, et.al. .
Journal: Journal of the Royal Society, Interface (J R Soc Interface), Vol. 14 (128), 2017 .
Snippet: We studied the population genetics of five immune-related mCNV loci associated with complex diseases (beta-defensins, CCL3L1/CCL4L1, FCGR3A, FCGR3B and FCGR2C) in 12 traditional Native American populations and found that the population structure parameters inferred for these mCNVs are comparable to but lower than those for single nucleotide polymorphisms studied in the same populations.
Affiliation: Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Departamento de Estatística, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Department of Genetics, University of Leicester, Leicester, UK. Department of Molecular Microbiology, Washington University in Saint Louis School of Medicine, St Louis, MO, USA. Department of Medicine, University of California San Diego, CA, USA. School of Health, University of Northampton, Northampton, UK. Johns Hopkins School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Asociación Benéfica PRISMA, Lima, Peru. Universidade Peruana Cayetano Heredia, Lima, Peru. Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil maira.r.rodrigues@gmail.com. .
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3: Title: Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
Authors: Suviolahti, Elina, et.al. .
Journal: Transplant immunology (Transpl Immunol), Vol. 32 (1): 9-17, 2015 .
Snippet: Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies obtained from HLA-sensitized (HS), non-HS patients and control individuals.
Affiliation: Transplant Immunology Laboratory, Comprehensive Transplant Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. Electronic address: elina.suviolahti@gmail.com. Transplant Immunology Laboratory, Comprehensive Transplant Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. Department of Pathology, Cedars-Sinai Medical Center/UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. Biostatistics Core, Research Institute & General Clinical Research Center & Cardiothoracic Surgery, Cedars-Sinai Medical Center, 8797 Beverly Blvd., Suite 215, Los Angeles, CA 90048, USA. Comprehensive Transplant Center, Cedars-Sinai Medical Center/UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. Transplant Immunology Laboratory, Comprehensive Transplant Center, Cedars-Sinai Medical Center/UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. .
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4: Title: Genomic analysis and differential expression of HMG and S100A family in human arthritis: upregulated expression of chemokines, IL-8 and nitric oxide by HMGB1.
Authors: Amin, Ashok R, et.al. .
Journal: DNA and cell biology (Dna Cell Biol), Vol. 33 (8): 550-65, 2014 .
Snippet: HMGB1 stimulated mRNA of 2 NFκB gene enhancers (NFκB1 and NFκB2), 16 CC and CXC chemokines (IL-8, CCL2, CCL20, CCL3, CCL3L1, CCL3L3, CCL4, CCL4L1, CCL4L2, CCL5, CCL8, CXCL1, CXCL10, CXCL2, CXCL3, and CXCL6) by ≥10-fold.
Affiliation: 1 Department of Bio-Medical Engineering, Virginia Tech and Virginia College of Osteopathic Medicine , RheuMatrix, Inc., Blacksburg, Virginia. .
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5: Title: Lack of clinical manifestations in asymptomatic dengue infection is attributed to broad down-regulation and selective up-regulation of host defence response genes.
Authors: Yeo, Adeline S L, et.al. .
Journal: PloS one, Vol. 9 (4): e92240, 2014 .
Snippet: Selected up-regulated genes include: RANTES (CCL5), MIP-1α (CCL3L1/CCL3L3), MIP-1β (CCL4L1), TGFβ (TGFB), and TIMP1.
Affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia; Perdana University Graduate School of Medicine & Centre for Bioinformatics, MARDI Complex, Jalan MAEPS Perdana, Serdang, Selangor Darul Ehsan, Malaysia. Perdana University Graduate School of Medicine & Centre for Bioinformatics, MARDI Complex, Jalan MAEPS Perdana, Serdang, Selangor Darul Ehsan, Malaysia. Institute for Basic Biomedical Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Perdana University Graduate School of Medicine & Centre for Bioinformatics, MARDI Complex, Jalan MAEPS Perdana, Serdang, Selangor Darul Ehsan, Malaysia; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, United States of America. Institute for Medical Molecular Biotechnology, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Sungai Buloh, Selangor, Malaysia. Department of Parasitology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. Department of Trauma and Emergency Medicine, University of Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, Malaysia. .
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6: Title: Comparison of a quantitative Real-Time PCR assay and droplet digital PCR for copy number analysis of the CCL4L genes.
Authors: Bharuthram, Avani, et.al. .
Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (Infect Genet Evol), Vol. 25, 2014 .
Snippet: The CCL4 encoding genes are CCL4, occurring in two copies per diploid genome (pdg), and the non-allelic CCL4L genes, comprised of CCL4L1 and CCL4L2, which are both found in multiple copies pdg.
Affiliation: Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: paxim@nicd.ac.za. .
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7: Title: Accuracy and differential bias in copy number measurement of CCL3L1 in association studies with three auto-immune disorders.
Authors: Carpenter, Danielle, et.al. .
Journal: BMC genomics, Vol. 12, 2011 .
Snippet: As the products of CCL3L1 and CCL4L1 potentially play a role in autoimmunity we performed case control association studies with Crohn's disease, rheumatoid arthritis and psoriasis clinical cohorts.
Affiliation: Centre for Genetics and Genomics and School of Biology, University of Nottingham, UK. .
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8: Title: Variability in patients with psoriasis: insights into the genotype-phenotype relationship.
Authors: Shelling, Michael L, et.al. .
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 131 (9): 1784, 2011 .
No Abstract available.
Affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. .
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9: Title: CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.
Authors: Pedrosa, Edurne, et.al. .
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 131 (9): 1830-7, 2011 .
Snippet: Our results showed that a high CNV (≥3 copies) is associated with psoriasis severity, whereas moderate disease correlated with a lower CNV (≤2 copies); specifically, the CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease.
Affiliation: Laboratory of Immunobiology for Research and Application to Diagnosis, Tissue and Blood Bank (BST), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain. .
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10: Title: Copy number variation in chemokine superfamily: the complex scene of CCL3L-CCL4L genes in health and disease.
Authors: Colobran, R, et.al. .
Journal: Clinical and experimental immunology (Clin Exp Immunol), Vol. 162 (1): 41-52, 2010 .
Snippet: Furthermore, the individual genes embedded in this CNVR account for an additional level of genetic and mRNA complexity: CCL4L1 and CCL4L2 have identical exonic sequences but produce a different pattern of mRNAs.
Affiliation: Laboratory of Immunobiology for Research and Application to Diagnosis (LIRAD), Tissue and Blood Bank (BST), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) Servei d'Immunologia, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain. .
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11: Title: Reply to: "Experimental aspects of copy number variant assays at CCL3L1".
Authors: He, Weijing, et.al. .
Journal: Nature medicine (Nat Med), Vol. 15 (10): 1117-20, 2009 .
No Abstract available.
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12: Title: Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation.
Authors: Colobran, R, et.al. .
Journal: Genes and immunity (Genes Immun), Vol. 10 (3): 254-9, 2009 .
Snippet: A combined analysis of CCL4L CNV and the rs4796195 CCL4L single nucleotide polymorphism demonstrated that the effect of CCL4L copy number in acute rejection is mainly because of the number of copies of the CCL4L1 allelic variant.
Affiliation: Laboratori d'Immunobiologia per a la Recerca i Aplicacions Diagnòstiques, Banc de Sang i Teixits, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain. .
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13: Title: Multiplex Paralogue Ratio Tests for accurate measurement of multiallelic CNVs.
Authors: Walker, Susan, et.al. .
Journal: Genomics, Vol. 93 (1): 98-103, 2009 .
Snippet: Here we build on our previous experience with Paralogue Ratio Tests (PRT) to develop PRT copy number determination at the CCL3L1/CCL4L1 copy number variant.
Affiliation: Institute of Genetics and School of Biology, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK. .
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14: Title: A genome-wide association study identifies protein quantitative trait loci (pQTLs).
Authors: Melzer, David, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 4 (5): e1000072, 2008 .
Snippet: Mechanisms implicated include altered rates of cleavage of bound to unbound soluble receptor (IL6R), altered secretion rates of different sized proteins (LPA), variation in gene copy number (CCL4L1) and altered transcription (GGT1).
Affiliation: Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom. .
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15: Title: CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.
Authors: Shao, W, et.al. .
Journal: Genes and immunity (Genes Immun), Vol. 8 (3): 224-31, 2007 .
Snippet: As members of the chemokine family, macrophage inflammatory protein 1 alpha (MIP-1alpha) and MIP-1beta are unique in that they both consist of non-allelic isoforms encoded by different genes, namely chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL3-like 1 (CCL3L1) and CCL4L1.
Affiliation: Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. .
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16: Title: Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.
Authors: Colobran, Roger, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 174 (9): 5655-64, 2005 .
Snippet: Human CCL4/macrophage inflammatory protein (MIP)-1beta and CCL3/MIP-1alpha are two highly related molecules that belong to a cluster of inflammatory CC chemokines located in chromosome 17.
Affiliation: Laboratory of Immunobiology for Research and Application to Diagnosis, Centre for Transfusion and Tissue Bank, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain. .
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17: Title: Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.
Authors: Howard, O M Zack, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 320 (3): 927-31, 2004 .
Snippet: CCL4 and CCL4L1 are two CC chemokine genes located at chromosome 17q21 whose mature proteins differ at only a single amino acid.
Affiliation: Laboratory of Molecular Immunoregulation, NCI-Frederick, Frederick, MD 21702, USA. .
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18: Title: CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12.
Journal: Genomics, Vol. 83 (4): 735-8, 2004 .
Snippet: These observations support the idea that the multiple copies of CCL3L1 and CCL4L1 present in a single diploid genome are the result of segmental duplication.
Affiliation: Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. modi@ncifcrf.gov .
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