1: Title: Kallikrein-related peptidases are activators of the CC chemokine CCL14.
Snippet: Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state.
Affiliation: Anhalt University of Applied Sciences, Molecular Biotechnology, Köthen, Germany. Martin Luther University Halle, Medical Faculty, Institute for Medical Immunology, Halle, Germany. Martin Luther University Halle, Medical Faculty, Institute for Anatomy and Cell Biology, Halle, Germany. Fraunhofer Institute for Cell Therapy and Immunology IZI, Department of Molecular Drug Biochemistry and Therapy Development, Halle, Germany. Department of Obstetrics and Gynecology, Technical University Munich, Munich, Germany. Hannover Medical School, Clinic of Internal Medicine, Hannover, Germany. .
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