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7 documents found
1: Title: DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.
Authors: Wu, Hui-Chen, et.al. .
Journal: Reproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol), 2019 .
Snippet: We observed DDT DMRs in three genes, CCDC85A, CYP1A1 and ZFPM2, each of which has been previously implicated in pubertal development and breast cancer susceptibility.
Affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States. Electronic address: hw2057@cumc.columbia.edu. Child Health and Development Studies, Public Health Institute, Berkeley, CA, United States. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States; Imprints Center, Columbia University Medical Center, New York, NY, United States; Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, United States. .
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2: Title: Cdc42 regulates junctional actin but not cell polarization in the Caenorhabditis elegans epidermis.
Authors: Zilberman, Yuliya, et.al. .
Journal: The Journal of cell biology (J Cell Biol), 2017 .
Snippet: We show that the RhoGAP PAC-1/ARHGAP21 inhibits CDC-42 activity at AJs, and loss of PAC-1 or the interacting linker protein PICC-1/CCDC85A-C blocks elongation in embryos with compromised AJ function.
Affiliation: Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY. Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY jeremy.nance@med.nyu.edu. Department of Cell Biology, New York University School of Medicine, New York, NY. .
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3: Title: Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Authors: Imamura, Minako, et.al. .
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2.
Affiliation: Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Laboratory for Omics Informatics, Omics Research Center, National Cerebral And Cardiovascular Center, Suita 565-8565, Japan. Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. Department of Diabetes Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo 160-0023, Japan. Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA. Saw Swee Hock School of Public Health, National University of Singapore, Singapore 138672, Singapore. Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P.14000, Mexico. Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA. Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea. Center for Non-Communicable Diseases, Karachi, Pakistan. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. First Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan. Health Administration Center, University of Toyama, Toyama 930-0194, Japan. Department of Public Health and Primary Care, University of Cambridge CB1 8RN, UK. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1RQ, UK. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK. Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup DK-2600, Denmark. Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen 2200, Denmark. Faculty of Medicine, University of Aalborg, Aalborg 9220, Denmark. Steno Diabetes Center, Gentofte 2820, Denmark. Department of Public Health, Aarhus University, Aarhus 8000, Denmark. Danish Diabetes Academy, Odense 5000, Denmark. Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle 7100, Denmark. Institute of Regional Health Research, University of Southern Denmark, Odense 5230, Denmark. Medical Department, Lillebaelt Hospital, Vejle 7100, Denmark. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA. Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona 08034, Spain. Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, Massachusetts 02114, USA. Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. Universidad Autónomas Metropolitana, Mexico City 09340, Mexico. Central University of Punjab, Bathinda, Punjab 151001, India. Health Center, Keio University, Tokyo 160-8582, Japan. Department of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan. Grand Tower Medical Court Life Care Clinic, Hiroshima 730-0012, Japan. Department of Internal Medicine, Kawasaki Medical School, Kurashiki 701-0192, Japan. Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan. Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-0034, Japan. Division of Metabolism and Endocrinology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki 216-8511, Japan. RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Department of Biomedical Science, Hallym University, Chunchon, Gangwon-do 24252, Republic of Korea. Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA. Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, n. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea. Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA. Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. Duke-National University of Singapore Graduate School, Singapore 169857, Singapore. Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan. Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara 903-0215, Japan. .
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4: Title: An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.
Authors: Klompstra, Diana, et.al. .
Journal: Nature cell biology (Nat Cell Biol), Vol. 17 (6): 726-35, 2015 .
Snippet: Here we show that the E-cadherin HMR-1, which is dispensable for adhesion, functions together with the α-catenin HMP-1, the p120 catenin JAC-1, and the previously uncharacterized linker PICC-1 (human CCDC85A-C) to bind PAC-1 and recruit it to contacts.
Affiliation: Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, New York 10016, USA. 1] Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, New York 10016, USA [2] Department of Cell Biology, NYU School of Medicine, New York, New York 10016, USA. .
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5: Title: DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.
Authors: Markham, Nicholas O, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 25 (17): 2592-603, 2014 .
Snippet: Moreover, all DIPA family members (Ccdc85a, Ccdc85b/DIPA, and Ccdc85c) interact reciprocally with p120 family members (p120, δ-catenin, p0071, and ARVCF), suggesting significant functional overlap.
Affiliation: Vanderbilt-Ingram Cancer Center, Cancer Biology Department, Vanderbilt University Medical Center, Nashville, TN 37232. Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235. Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030. Epithelial Biology Center, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232. Vanderbilt-Ingram Cancer Center, Cancer Biology Department, Vanderbilt University Medical Center, Nashville, TN 37232 al.reynolds@vanderbilt.edu. .
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6: Title: Genome wide association study of age at menarche in the Japanese population.
Authors: Tanikawa, Chizu, et.al. .
Journal: PloS one, Vol. 8 (5): e63821, 2013 .
Snippet: In addition, six loci in or near CCDC85A, LOC100421670, CA10, ZNF483, ARNTL, and RXRG exhibited suggestive association with AAM (P<0.05).
Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. .
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7: Title: Real-time PCR analysis of candidate imprinted genes on mouse chromosome 11 shows balanced expression from the maternal and paternal chromosomes and strain-specific variation in expression levels.
Authors: Tuskan, Robert G, et.al. .
Journal: Epigenetics : official journal of the DNA Methylation Society (Epigenetics), Vol. 3 (1): 43-50, 2008 Jan-Feb .
Snippet: We have tested 30 candidate genes (Havcr2, Camk2b, Ccdc85a, Cntnap1, Ikzf1, 5730522E02Rik, Gria1, Zfp39, Sgcd, Jup, Nxph3, Spnb2, Asb3, Rasd1, Map2k3, Map2k4, Trp53, Serpinf1, Crk, Rasl10b, Itga3, Hoxb5, Cbx1, Pparbp, Igfbp4, Smarce1, Stat3, Atp6v0a1, Nbr1 and Meox1), two known imprinted genes (Grb10 and Impact) and Nf1, which has not been previously identified as an imprinted gene.
Affiliation: Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. .
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