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2 documents found
1: Title: The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
Authors: Gao, Yanzhe, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 8 (1): 15304, 2018 .
Snippet: HORMAD1-mediated HR is a neomorphic activity that is independent of its meiotic partners (including HORMAD2 and CCDC36.
Affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA. Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA. Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA. cyrus_vaziri@med.unc.edu. Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA. cyrus_vaziri@med.unc.edu. .
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2: Title: Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.
Authors: Stanzione, Marcello, et.al. .
Journal: Nature cell biology (Nat Cell Biol), Vol. 18 (11): 1208-1220, 2016 .
Snippet: We identify CCDC36 as a direct interactor of HORMAD1 (IHO1) that is essential for DSB formation.
Affiliation: Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1-1-1, Tokyo 113-0032, Japan. Institute of Human Genetics, UPR 1142, CNRS, University of Montpellier, 141, rue de la Cardonille, 34396 Montpellier, France. Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. .
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