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28 documents found
1: Title: Identification of Caveolin-1 Domain Signatures via Graphlet Analysis of Single Molecule Super-Resolution Data.
Authors: Khater, Ismail M, et.al. .
Journal: Bioinformatics (Oxford, England) (Bioinformatics), 2019 .
Snippet: As a supervised learning approach, we applied a wide-field CAVIN1/PTRF mask to CAVIN1/PTRF-transfected PC3 prostate cancer cells (PC3-PTRF cells) and used the random forest classifier to classify blobs based on graphlet frequency distribution (GFD).
Affiliation: Medical Image Analysis Lab, School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. .
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2: Title: The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae.
Authors: Rausch, Valentina, et.al. .
Journal: Current biology : CB (Curr Biol), Vol. 29 (2): 242-255.e6, 2019 .
Snippet: CAVEOLIN1 and CAVIN1, the two essential caveolar genes, are direct target genes of YAP/TAZ, regulated via TEA domain (TEAD) transcription factors.
Affiliation: University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh bioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA. MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK. University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh bioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address: carsten.g.hansen@ed.ac.uk. .
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3: Title: BioID identifies proteins involved in the cell biology of caveolae.
Authors: Mendoza-Topaz, C, et.al. .
Journal: PloS one, Vol. 13 (12): e0209856, 2018 .
Snippet: We conclude that BioID will be useful in identification of new proteins involved in the cell biology of caveolae, and that interaction between CD2AP and cavin1 may have an important role in regulating the sub-cellular distribution of caveolae.
Affiliation: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. .
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4: Title: Postmortem Findings in a Young Man With Congenital Generalized Lipodystrophy, Type 4 Due to CAVIN1 Mutations.
Authors: Patni, Nivedita, et.al. .
Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab), Vol. 104 (3): 957-960, 2019 .
Snippet: Context: Congenital generalized lipodystrophy, type 4 (CGL4) is a rare autosomal recessive disorder caused by mutations in caveolae-associated protein 1. Patients with CGL4 also have myopathy and cardiomyopathy with a predisposition for sudden death due to ventricular arrhythmias.
Affiliation: Division of Pediatric Endocrinology, Department of Pediatrics and Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas. Department of Pathology, UT Southwestern Medical Center, Dallas, Texas. Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and the Center for Human Nutrition; UT Southwestern Medical Center, Dallas, Texas. .
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5: Title: Integrated profiling identifies caveolae-associated protein 1 as a prognostic biomarker of malignancy in glioblastoma patients.
Authors: Guo, Qing, et.al. .
Journal: CNS neuroscience & therapeutics (Cns Neurosci Ther), 2018 .
Snippet: To this end, in this study, we evaluated CAVIN1 expression in glioma tissue as well as the correlation between CAVIN1 expression and prognosis in glioma patients using the data collected from clinical samples or from the Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), Rembrandt, and Gene Expression Omnibus (GEO) data sets.
Affiliation: Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, China. .
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6: Title: The caveolae-associated coiled-coil protein, NECC2, regulates insulin signalling in Adipocytes.
Authors: Trávez, Andrés, et.al. .
Journal: Journal of cellular and molecular medicine (J Cell Mol Med), Vol. 22 (11): 5648-5661, 2018 .
Snippet: Furthermore, NECC2 co-immunoprecipitated with caveolin-1 (CAV1) and exhibited a distribution pattern similar to that of the components of adipocyte caveolae, CAV1, Cavin1, the insulin receptor and cortical actin.
Affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. Reina Sofía University Hospital, Córdoba, Spain. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. Metabolic Research Laboratory, Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain. Unidad de Gestion Clínica de Endocrinología y Nutrición, Laboratorio del Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain. Institut des Neurosciences Cellulaires et Intégratives (INCI), Centre National de la Recherche Scientifique (CNRS UPR 3212), Université de Strasbourg, Strasbourg, France. .
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7: Title: A variable undecad repeat domain in cavin1 regulates caveola formation and stability.
Authors: Tillu, Vikas A, et.al. .
Journal: EMBO reports (Embo Rep), Vol. 19 (9), 2018 .
Snippet: Of the four cavin family members, only cavin1 is strictly required for caveola formation.
Affiliation: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Qld, Australia. Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Qld, Australia b.collins@imb.uq.edu.au r.parton@imb.uq.edu.au. Centre for Microscopy and Microanalysis, The University of Queensland, St. Lucia, Qld, Australia. .
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8: Title: Super Resolution Network Analysis Defines the Molecular Architecture of Caveolae and Caveolin-1 Scaffolds.
Authors: Khater, Ismail M, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 8 (1): 9009, 2018 .
Snippet: We developed a computational pipeline and applied it to analyzing 3D point clouds of SMLM localizations (event lists) of the caveolar coat protein, caveolin-1 (Cav1), in prostate cancer cells differentially expressing CAVIN1 (also known as PTRF), that is also required for caveolae formation.
Affiliation: Medical Image Analysis Lab, School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. irnabi@mail.ubc.ca. Medical Image Analysis Lab, School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. hamarneh@sfu.ca. .
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9: Title: The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes.
Authors: Huang, Kai, et.al. .
Journal: Theranostics, Vol. 8 (6): 1540-1557, 2018 .
Snippet: Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in various malignancies.
Affiliation: Tianjin Neurological Institute, Key Laboratory of Post-neurotrauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin 300052, China. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China. Department of Neurosurgery, Hebei University Affiliated Hospital, Baoding 071000, China. Beijing Neurosurgical Institute, Capital Medical University,Beijing,100050,China. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University , Tianjin 300072, China. College of Fundamental Medicine, Hebei University, Baoding 071000, China. Department of Medicine, Department of Surgery, the University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .
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10: Title: Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA splicing factors during adipogenesis.
Authors: Mugabo, Yves, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), 2018 .
Snippet: Ptrf/Cavin1) within the 14-3-3ζ interactome, confirming the utility of this approach to detect adipogenic factors.
Affiliation: CRCHUM/University of Montreal, Canada. University of British Columbia, Canada. CRCHUM/University of Montreal, Canada; gareth.lim@umontreal.ca. .
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11: Title: Ptrf transgenic mice exhibit obesity and fatty liver.
Authors: Li, Qian, et.al. .
Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol), 2018 .
Snippet: Polymerase I and transcript release factor (Ptrf, also known as Cavin1) is an essential component in the biogenesis and function of caveolae.
Affiliation: Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China. Key Laboratory of Human Disease, Comparative Medicine of the Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing, China. Center of Metabolic Disease Research, Nanjing Medical University, Hanzhong Road 140, Nanjing, 210029, China. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. .
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12: Title: An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse.
Authors: Osmani, Naël, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), 2017 .
Snippet: Based on FRAP and endocytosis assays, integrin recycling between both sites requires the small GTPase Arf6, but neither Caveolin1 (Cav1) nor Cavin1.
Affiliation: IGBMC, Development and Stem Cells Program, CNRS (UMR 7104)/INSERM (U964), 67400 Illkirch, France. Inserm U1109, MN3T, 3 avenue Molière 67200 Strasbourg, France. Université de Strasbourg, Strasbourg 67000, France. LabEx Medalis, Université de Strasbourg, 67000, Strasbourg. Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67000 Strasbourg, France. These authors contributed equally to this work. Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), D-85764 Neuherberg. Laboratory of Cell Physics, ISIS/IGBMC, CNRS UMR 7006, 67000 Strasbourg, France. Biomimetic Systems for Cell Engineering, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain. IGBMC, Development and Stem Cells Program, CNRS (UMR 7104)/INSERM (U964), 67400 Illkirch, France michel.labouesse@upmc.fr riveline@unistra.fr. UMR7622-CNRS, IBPS, Université Pierre et Marie Curie, Sorbonne Universités, 7-9, quai Saint Bernard 75005 Paris, France. .
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13: Title: Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination.
Authors: Seemann, Eric, et.al. .
Journal: eLife, Vol. 6, 2017 .
Snippet: This allowed for dissecting bona fide caveolar functions from those supported by mere caveolin presence and also demonstrated that neither caveolin3 nor caveolin3 and cavin1 are sufficient to form caveolae.
Affiliation: Institute for Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany. Electron Microscopy Center, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany. Institute for Human Genetics, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany. Institute of Pathology, Division of Neuropathology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany. .
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14: Title: Caveolin-1 restricts group A Streptococcus invasion of non-phagocytic host cells.
Authors: Lim, Jin Yan, et.al. .
Journal: Cellular microbiology (Cell Microbiol), 2017 .
Snippet: Caveolae are composed of two major proteins, caveolin-1 (CAV1) and cavin-1/polymerase transcript factor I (CAVIN1).
Affiliation: Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia. Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia. Centre for Microscopy and Microanalysis, The University of Queensland, St Lucia, QLD. .
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15: Title: Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane.
Authors: Hirama, Takashi, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (34): 14292-14307, 2017 .
Snippet: Using live-cell, single-particle tracking of GFP-labeled Cav1 and ultrastructural analyses, we compared the effect of PtdSer disruption or phosphoinositide depletion with caveola disassembly caused by cavin1 loss.
Affiliation: From the Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada. the Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G1X8, Canada. the Department of Respiratory Medicine, Saitama Medical University, Moroyama, Saitama 3500495, Japan. the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204. the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. the Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia. The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada. the Department of Oral Biology, School of Dental Medicine, the State University of New York at Buffalo, Buffalo, New York 14214, and. From the Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada, fairng@smh.ca. the Institute for Biomedical Engineering and Science Technology (iBEST), Ryerson University and St. Michael's Hospital, Toronto, Ontario M5B 2K3, Canada. .
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16: Title: Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle.
Authors: Zhu, Baoyi, et.al. .
Journal: PloS one, Vol. 12 (5): e0176759, 2017 .
Snippet: Recent work has demonstrated that myocardin family coactivators (MYOCD, MKL1), which are important for contractile differentiation and cell motility, increase caveolin (CAV1, CAV2, CAV3) and cavin (CAVIN1, CAVIN2, CAVIN3) transcription, but several aspects of this control mechanism remain to be investigated.
Affiliation: Department of Experimental Medical Science, Lund University, Lund, Sweden. Department of Urology, the Sixth Affiliated Hospital of Guangzhou Medical University, Guangdong, China. Department of Urology, Clinical Sciences, Lund University, Lund, Sweden. .
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17: Title: Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.
Authors: Stoeber, Miriam, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 113 (50): E8069-E8078, 2016 .
Snippet: Here, purified Cavin1 60S complexes were analyzed structurally in solution and after liposome reconstitution by electron cryotomography.
Affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom. Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland. Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland ari.helenius@bc.biol.ethz.ch kay@strubi.ox.ac.uk. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom; ari.helenius@bc.biol.ethz.ch kay@strubi.ox.ac.uk. .
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18: Title: P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Authors: Tome, Margaret E, et.al. .
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab), Vol. 36 (11): 1913-1928, 2016 .
Snippet: Peripheral inflammatory pain also increased endothelial cell luminal staining of polymerase 1 and transcript release factor/cavin1 and serum deprivation response protein/cavin2, two caveolar scaffold proteins, without changing caveolin1 or protein kinase C delta binding protein/cavin3 location.
Affiliation: Department of Pharmacology, University of Arizona, Tucson, USA mtome@email.arizona.edu. Department of Pharmacology, University of Arizona, Tucson, USA. .
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19: Title: A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation.
Authors: Tillu, Vikas A, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 26 (20): 3561-9, 2015 .
Snippet: This mutually exclusive PI-binding/ubiquitylation mechanism may help maintain low levels of cytosolic cavin1 in resting cells, a prerequisite for cavins acting as signaling modules following release from caveolae.
Affiliation: Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland 4072, Australia. Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland 4072, Australia Centre for Microscopy and Microanalysis, University of Queensland, St. Lucia, Queensland 4072, Australia r.parton@imb.uq.edu.au. .
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20: Title: Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels.
Authors: Tome, Margaret E, et.al. .
Journal: Journal of neurochemistry (J Neurochem), Vol. 134 (2): 200-10, 2015 .
Snippet: Caveolar constituents, caveolin1, cavin1, and cavin2, co-localized with PgP in these fractions indicating the two pools contained caveolae.
Affiliation: Department of Medical Pharmacology, University of Arizona, Tucson, Arizona, USA. .
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