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4 documents found
1: Title: Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs.
Authors: Zinovieva, Olga L, et.al. .
Journal: Biochimie, 2018 .
Snippet: Using RNA-Seq, RT-qPCR, bioinformatics, and studies utilizing the murine tumor xenograft model, we have found significant and consistent changes in the abundance of five lincRNAs (LINC00973, LINC00941, CASC19, CCAT1, and BCAR4) upon treatment of both HT-29 and HCT-116 cells with 5-fluorouracil, oxaliplatin, and irinotecan at different doses and durations; both in vitro and in vivo.
Affiliation: Engelhardt Institute of Molecular Biology, the Russian Academy of Sciences, 119991, Moscow, Russia. Engelhardt Institute of Molecular Biology, the Russian Academy of Sciences, 119991, Moscow, Russia; Institute of Biomedical Chemistry, the Russian Academy of Sciences, 119121, Moscow, Russia. Engelhardt Institute of Molecular Biology, the Russian Academy of Sciences, 119991, Moscow, Russia. Electronic address: niklisitsyn@gmail.com. .
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2: Title: Expression and Function of Long Non-coding RNA CASC19 in Colorectal Cancer.
Authors: Wang, Jian Jun, et.al. .
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao), Vol. 39 (6): 756-761, 2017 .
Snippet: 目的 探讨长链非编码RNA CASC19在结直肠癌中的表达、功能及临床意义。方法应用实时荧光定量PCR检测40对结直肠癌及相应癌旁正常组织中CASC19的表达,分析其表达与临床病理参数的关系;检测CASC19在5株结直肠癌细胞中的表达,应用小干扰RNA下调结直肠癌细胞中CASC19的表达,应用Transwell实验研究CASC19对结直肠癌细胞体外迁移的影响。结果 CASC19在结直肠癌组织中的表达明显高于相对应的癌旁组织,差异具有统计学意义(t=5.527,P<0.000
Affiliation: Department of Histology and Embryology,Yijishan Hospital of Wannan Medical College,Wannan Medical College,Wuhu,Anhui 241002,China. Department of Pathology,Yijishan Hospital of Wannan Medical College,Wannan Medical College,Wuhu,Anhui 241002,China. .
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3: Title: CCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 'gene desert', serve as important prognostic biomarkers in colorectal cancer.
Authors: Ozawa, T, et.al. .
Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol), Vol. 28 (8): 1882-1888, 2017 .
Snippet: Results: The expression of CCAT1, CCAT1-L, CCAT2, PVT1, and CASC19 were elevated in cancer tissues (P = 0.039, <0.001, 0.018, <0.001, 0.002, respectively).
Affiliation: Center for Gastrointestinal Research; Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute, Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, USA. Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie Japan. Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo Japan. Department of Specialized Surgery, Tokyo Medical and Dental University, Tokyo, Japan. Division of Cancer Medicine, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA. .
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4: Title: Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.
Authors: Teerlink, Craig C, et.al. .
Journal: Human genetics (Hum Genet), Vol. 135 (8): 923-38, 2016 .
Snippet: The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of 8q24.21 that contained the minor alleles of three rare SNPs (dosage minor allele frequencies <1.7 %), rs183373024 (PRNCR1), previously associated SNP rs188140481, and rs138042437 (CASC19).
Affiliation: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA. craig.teerlink@utah.edu. Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK. Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA. Department of Urology, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA. Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA. Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA. Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. Department of Urology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA. Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 27599, USA. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, 3010, Australia. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia. Department of Pathology, University of Melbourne, Melbourne, 3010, Australia. Department of Urology, University Hospital Ulm, 53179, Ulm, Germany. Institute for Human Genetics, University of Ulm, 89081, Ulm, Germany. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA, 98109, USA. Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA. Department of Medical Biochemistry and Genetics, University of Turku, 20520, Turku, Finland. Department of Urology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland. Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, 20520, Turku, Finland. Brady Urological Institute, Johns Hopkins University, Baltimore, MD, 21287, USA. Program for Personalized Cancer Care, NorthShore University Health System, Evanston, IL, 60201, USA. CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020, Paris, France. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA. Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA. Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, 84148, USA. .
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