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17 documents found
1: Title: CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis.
Authors: Li, Weilin, et.al. .
Journal: Oncogene, Vol. 37 (50): 6383-6398, 2018 .
Snippet: LKB1-AMPK activation in GC cell lines was tumor suppressive, as metformin (an AMPK activator) inhibited GC cell growth in the CAB39L-silenced cells.
Affiliation: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China. Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing, China. State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. endersng@surgery.cuhk.edu.hk. Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. junyu@cuhk.edu.hk. .
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2: Title: Leukemia-associated gene MLAA-34 reduces arsenic trioxide-induced apoptosis in HeLa cells via activation of the Wnt/β-catenin signaling pathway.
Authors: Zhang, Pengyu, et.al. .
Journal: PloS one, Vol. 12 (10): e0186868, 2017 .
Snippet: Our laboratory previously used the SEREX method in U937 cells and identified a novel leukemia-associated gene MLAA-34, a novel splice variant of CAB39L associated with acute monocytic leukemia, that exhibited anti-apoptotic activities in U937 cells.
Affiliation: Department of Hematology, Second Affiliated Hospital, Xi' an Jiaotong University, Xi'an, Shaanxi, China. Department of Histology&Embryology, Xi'an Medical College, Xi'an, Shaanxi, China. Shaanxi Blood Center, Xi'an, Shaanxi, China. .
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3: Title: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.
Authors: Pulito, Claudio, et.al. .
Journal: Cell discovery (Cell Discov), Vol. 3, 2017 .
Snippet: Mechanistically, this reduction in miR-21-5p enhanced the expression of critical upstream activators of the AMP-activated protein kinase, calcium-binding protein 39-like and Sestrin-1, leading to AMP-activated protein kinase activation and inhibition of mammalian target of rapamycin signaling.
Affiliation: Molecular Chemoprevention Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy. Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy. Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy. Unit of Endocrinological Gynecology, Ospedale Sant'Anna di Torino, Turin, Italy. SAFU, 'Regina Elena' National Cancer Institute, Rome, Italy. Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Epigénétique et Épigénomique des Carcinomes Hépathocellulaires Viro-Induits du Centre de Recherche en Cancérologie de Lyon, Lyon, France. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Division of Medical Oncology A, Italian National Cancer Institute 'Regina Elena', Rome, Italy. Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada. .
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4: Title: Prokaryotic expression of MLAA-34 and generation of a novel human ScFv against MLAA-34 by phage display technology.
Authors: Zhang, Yang, et.al. .
Journal: Oncotarget, Vol. 8 (24): 39077-39086, 2017 .
Snippet: Then, MLAA-34 was used as antigen for biopanning anti-MLAA-34 single chain antibody fragment (ScFv) from a fully human ScFv library, and a high affinity ScFv named MA1 was selected by phage-ELISA.
Affiliation: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China. .
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5: Title: [Antiapoptotic Effect of the Leukemia Associated Gene MLAA-34 in HeLa Cells].
Authors: Zhang, Peng-Yu, et.al. .
Journal: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (Zhongguo Shi Yan Xue Ye Xue Za Zhi), Vol. 24 (2): 363-8, 2016 .
Snippet: METHODS: The MLAA-34 recombinant lentiviral expression vector was constructed, and the stably transfected HeLa cell line with high expression of MLAA-34 was set up; As(2)O(3) was used to induce apoptosis; the MTT assay, colony formation test and flow cytometry were used to detect the ability of cell proliferation, colong formation, apoptosis and cell cycle changes respectively.
Affiliation: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. E-mail: zhangpengyu2004@126.com. Department of Histology & Embryology, Xi'an Medical College, Xi'an 710021, Shaanxi Province, China. Shaanxi Blood Center, Xi'an 710061, Shaanxi Province, China. Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. .
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6: Title: Genome-wide association studies for feed intake and efficiency in two laying periods of chickens.
Authors: Yuan, Jingwei, et.al. .
Journal: Genetics, selection, evolution : GSE (Genet Sel Evol), Vol. 47, 2015 .
Snippet: The CAB39L gene can be considered as a promising candidate for FI1.
Affiliation: National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China. amstrongyuan@gmail.com. Jiangsu Institute of Poultry Science, Yangzhou, 225125, People's Republic of China. sqbreeding@126.com. National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China. yiguoqiang20@hotmail.com. Jiangsu Institute of Poultry Science, Yangzhou, 225125, People's Republic of China. meng-2005@163.com. Jiangsu Institute of Poultry Science, Yangzhou, 225125, People's Republic of China. yzdtc@126.com. National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China. cjsun@cau.edu.cn. National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China. quluj@cau.edu.cn. Jiangsu Institute of Poultry Science, Yangzhou, 225125, People's Republic of China. shenman2005@163.com. Jiangsu Institute of Poultry Science, Yangzhou, 225125, People's Republic of China. quliang19820603@163.com. National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China. nyang@cau.edu.cn. .
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7: Title: Frameshift Mutations of CAB39L, an Activator of LKB1 Tumor Suppressor, in Gastric and Colorectal Cancers.
Authors: Choi, Mi Ryoung, et.al. .
Journal: Pathology oncology research : POR (Pathol Oncol Res), Vol. 22 (1): 225-6, 2016 .
No Abstract available.
Affiliation: Departments of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, South Korea. General Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Departments of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, South Korea. suhulee@catholic.ac.kr. .
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8: Title: Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
Authors: Rahmioglu, Nilufer, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 24 (4): 1185-99, 2015 .
Snippet: In addition to 7p15.2, we identify four more variants with statistically significant evidence of involvement in both endometriosis and WHRadjBMI (in/near KIFAP3, CAB39L, WNT4, GRB14); two of these, KIFAP3 and CAB39L, are novel associations for both traits.
Affiliation: Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Statistical Genetics. Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA, Unit of Nutritional Epidemiology, Institute for Environmental Medicine, Karolinska Institutet, PO Box 210, SE-171 77 Stockholm, Sweden. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK. Neurogenetics. Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Department of Biostatistics, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK. Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142 MA, USA and. Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Nuffield Department of Obstetrics and Gynaecology & Endometriosis CaRe Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK krinaz@well.ox.ac.uk. .
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9: Title: The expression and functional characterization associated with cell apoptosis and proteomic analysis of the novel gene MLAA-34 in U937 cells.
Authors: Zhang, Wen-Juan, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 29 (2): 491-506, 2013 .
Snippet: Moreover, the effect of MLAA-34 apoptosis may be through interaction with the Ras, Wnt, calcium and chemokine signaling pathways and thirteen of the annotated proteins may interact with MLAA-34 and participate in carcinogenesis directly.
Affiliation: Department of Clinical Hematology, Affiliated No. 2 Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, PR China. .
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10: Title: miR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: from quantitative proteomics to post-transcriptional study.
Authors: Lo, Wan-Yu, et.al. .
Journal: Journal of proteomics (J Proteomics), Vol. 77, 2012 .
Snippet: The TPT1, ITGA6 and CAB39L genes were displayed the higher transcriptions level in the tumor tissues and the TPT1, ITGA6 and CAB39L proteins were also shown overexpression in the tumor tissues from the same patients.
Affiliation: Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. .
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11: Title: Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken.
Authors: Zhang, H, et.al. .
Journal: Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie (J Anim Breed Genet), Vol. 128 (5): 366-75, 2011 .
Snippet: This region contained five RefSeq genes (RB1, P2RY5, FNDC3A, MLNR and CAB39L) on the University of California Santa Cruz website.
Affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, China.   .
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12: Title: Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
Authors: Amin, N, et.al. .
Journal: Molecular psychiatry (Mol Psychiatry), Vol. 17 (11): 1116-29, 2012 .
Snippet: Our results from GWASs and expression analysis also strongly implicate CAB39L in coffee drinking.
Affiliation: Unit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. .
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13: Title: Leukemia-associated antigens are immunogenic and have prognostic value in acute myeloid leukemia.
Authors: Zhang, Lu, et.al. .
Journal: Immunotherapy, Vol. 3 (6): 697-9, 2011 .
No Abstract available.
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14: Title: Quantitative assessment of MLAA-34 expression in diagnosis and prognosis of acute monocytic leukemia.
Authors: Zhao, Jianqiang, et.al. .
Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother), Vol. 60 (4): 587-97, 2011 .
Snippet: In 126 patients with de novo acute myeloid leukemia, the level of MLAA-34 expression and protein expression ratio were determined by using quantitative reverse transcriptase-PCR and western blot, respectively.
Affiliation: Department of Clinical Hematology, 2nd Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 157, 5th West Road, 710004, Xi'an, Shaanxi, People's Republic of China. .
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15: Title: microRNA-451: A conditional switch controlling glioma cell proliferation and migration.
Authors: Godlewski, Jakub, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), Vol. 9 (14): 2742-8, 2010 .
Snippet: MiR-451 levels are regulated by glucose; under conditions of abundant energy miR-451 expression is high, and the suppression of AMPK signaling allows cells to maintain elevated proliferation rates via unrestrained mTOR activation.
Affiliation: Dardinger Laboratory for Neuro-oncology and Neurosciences, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA. .
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16: Title: Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34.
Authors: Zhang, Peng-Yu, et.al. .
Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother), Vol. 58 (2): 281-90, 2009 .
Snippet: Because the functions of MLAA-34 and CAB39L are both very unclear, then we investigated the role of MLAA-34 in U937 cell line using RNA interference technology.
Affiliation: Department of Clinical Hematology, Affiliated No. 2 Hospital, Xi'an Jiaotong University School of Medicine, The west five road, 157#, 710004, Xi'an, Shaanxi, China. .
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17: Title: Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome.
Authors: Garrido, N, et.al. .
Journal: Fertility and sterility (Fertil Steril), Vol. 91 (4 Suppl): 1307-10, 2009 .
Snippet: Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology.
Affiliation: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain. nicolas.garrido@ivi.es .
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