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14 documents found
1: Title: RWCFusion: identifying phenotype-specific cancer driver gene fusions based on fusion pair random walk scoring method.
Authors: Zhao, Jianmei, et.al. .
Journal: Oncotarget, Vol. 7 (38): 61054-61068, 2016 .
Snippet: Finally, we applied RWCFusion to breast cancer and found that top 13 gene fusions, such as BCAS3-BCAS4, NOTCH-NUP214, MED13-BCAS3 and CARM-SMARCA4, have been previously proved to be drivers for breast cancer.
Affiliation: School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing, 163319, China. The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, 515041, China. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. Department of Mathematics, Heilongjiang Institute of Technology, Harbin, 150050, China. School of Nursing and Pharmacology, Daqing Campus, Harbin Medical University, Daqing, 163319, China. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. .
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2: Title: Developmental validation studies of epigenetic DNA methylation markers for the detection of blood, semen and saliva samples.
Authors: Silva, Deborah S B S, et.al. .
Journal: Forensic science international. Genetics (Forensic Sci Int Genet), Vol. 23, 2016 .
Snippet: A set of epigenetic markers, ZC3H12D, BCAS4 and cg06379435, have been developed to produce unique and specific patterns of DNA methylation that can be used to identify semen, saliva, and blood, respectively.
Affiliation: Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA; Faculty of Biosciences, Laboratory of Human and Molecular Genetics, PUCRS, Porto Alegre, Brazil. Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA. School of Criminal Justice, University of Southern Mississippi, Hattiesburg, MS, USA. DNA Laboratory, Broward County Sheriff's Office, Fort Lauderdale, FL, USA. Faculty of Biosciences, Laboratory of Human and Molecular Genetics, PUCRS, Porto Alegre, Brazil. Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA. Electronic address: mccordb@fiu.edu. .
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3: Title: Characterization of cellular and extracellular DNA in saliva.
Authors: Taki, Takashi, et.al. .
Journal: Legal medicine (Tokyo, Japan) (Leg Med (tokyo)), Vol. 17 (6): 471-4, 2015 .
Snippet: The methylation patterns of the BCAS4 gene were different among donors, but no significant difference was observed between cellular and extracellular DNA.
Affiliation: Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: taki@research.twmu.ac.jp. Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. .
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4: Title: Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.
Authors: Natrajan, Rachael, et.al. .
Journal: The Journal of pathology (J Pathol), Vol. 232 (5): 553-65, 2014 .
Snippet: Forced expression of in-frame fusion genes (SLC2A1-FAF1 and BCAS4-AURKA) resulted in increased viability of breast cancer cells.
Affiliation: The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. .
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5: Title: Detecting and visualizing gene fusions.
Authors: Supper, Jochen, et.al. .
Journal: Methods (San Diego, Calif.) (Methods), Vol. 59 (1): S24-8, 2013 .
Snippet: We discuss several gene fusion events, like BCAS3-BCAS4 that was only detected in the breast cancer cell line MCF7.
Affiliation: Genomatix Software GmbH, Bayerstr. 85a, 80335 München, Germany. supper@genomatix.de .
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6: Title: The determination of tissue-specific DNA methylation patterns in forensic biofluids using bisulfite modification and pyrosequencing.
Authors: Madi, Tania, et.al. .
Journal: Electrophoresis, Vol. 33 (12): 1736-45, 2012 .
Snippet: The C20orf117 locus differentiated blood from sperm, saliva, and epithelial cells and saliva was differentiated from blood, sperm, and epithelial cells at a fourth locus, BCAS4.
Affiliation: Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA. .
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7: Title: Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.
Authors: Chen, Lu, et.al. .
Journal: Disease markers (Dis Markers), Vol. 32 (3): 195-202, 2012 .
Snippet: Eighty two hypermethylated genes were acquired by array analysis and 5 genes (BCAS4, CHRM2, FAM5C, PRAC and MYLK) were selected as the candidate genes.
Affiliation: Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
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8: Title: Fusion gene microarray reveals cancer type-specificity among fusion genes.
Authors: Løvf, Marthe, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 50 (5): 348-57, 2011 .
Snippet: Two additional fusion genes, BCAS4-BCAS3 in the MCF-7 breast cancer cell line and CCDC6-RET in the TPC-1 thyroid cancer cell line were validated as true positive fusion transcripts.
Affiliation: Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. .
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9: Title: Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer.
Authors: Arcaroli, John J, et.al. .
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res), Vol. 16 (16): 4165-77, 2010 .
Snippet: A K-TSP classifier (TOX>GLIS2, TSPAN7>BCAS4, and PARD6G>NXN) was predictive for sensitivity to saracatinib.
Affiliation: Division of Medical Oncology, University of Colorado, Denver, Colorado, USA. .
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10: Title: DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification.
Authors: Nowee, M E, et.al. .
Journal: The Journal of pathology (J Pathol), Vol. 213 (1): 46-55, 2007 .
Snippet: Other previously unappreciated gained/amplified genes included PSMB4 on 1q, MTSS1 on 8q, TEAD4 and TSPAN9 on 12p, and BCAS4 on 20q.
Affiliation: Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands. .
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11: Title: Multigene deletions on chromosome 20q13.13-q13.2 including SALL4 result in an expanded phenotype of Okihiro syndrome plus developmental delay.
Authors: Borozdin, Wiktor, et.al. .
Journal: Human mutation (Hum Mutat), Vol. 28 (8): 830, 2007 .
Snippet: In this patient, four genes (MOCS3, DPM1, ADNP, BCAS4) are deleted, which were not affected in the other three cases, suggesting that the deletion of one or more of these genes contributes to the mental retardation.
Affiliation: Praxis für Humangenetik, Freiburg, Germany. .
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12: Title: Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs).
Authors: Ruan, Yijun, et.al. .
Journal: Genome research (Genome Res), Vol. 17 (6): 828-38, 2007 .
Snippet: One was validated as the product of a fusion gene between BCAS4 and BCAS3 resulting from an amplification followed by a translocation event between the two loci, chr20q13 and chr17q23.
Affiliation: Genome Technology and Biology Group, Genome Institute of Singapore, Singapore 138672, Singapore. ruanyj@gis.a-star.edu.sg .
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13: Title: Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.
Authors: Hahn, Yoonsoo, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (P Natl Acad Sci Usa), Vol. 101 (36): 13257-61, 2004 .
Snippet: The fusion gene encodes the full-length RGS17 protein, a regulator of G protein-coupled signaling, under the control of the IRA1 gene promoter.
Affiliation: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. .
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14: Title: Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.
Authors: Bärlund, Maarit, et.al. .
Journal: Genes, chromosomes & cancer (Gene Chromosome Canc), Vol. 35 (4): 311-7, 2002 .
Snippet: The BCAS4-BCAS3 fusion transcript was detected only in MCF7 cells, but the BCAS4 gene was also overexpressed in nine of 13 breast cancer cell lines.
Affiliation: Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland. .
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