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14 documents found
1: Title: Comparative analysis of gene expression profiles in children with type 1 diabetes mellitus.
Authors: Qian, Liwei, et.al. .
Journal: Molecular medicine reports (Mol Med Report), 2019 .
Snippet: Electronic validation and diagnostic value analysis of the identified DEGs [cytokine inducible SH2 containing protein (CISH), SR‑related CTD associated factor 11 (SCAF11), estrogen receptor 1 (ESR1), Rho GTPase activating protein 25 (ARHGAP25), major histocompatibility complex, class II, DR β4 (HLA‑DRB4) and interleukin 23 subunit α (IL23A)] was performed in the GEO dataset.
Affiliation: Department of Pediatrics, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252000, P.R. China. Department of Pediatrics, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China. .
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2: Title: Genome-Wide Association Study of Meiotic Recombination Phenotypes.
Authors: Begum, Ferdouse, et.al. .
Journal: G3 (Bethesda, Md.) (G3 (bethesda)), Vol. 6 (12): 3995-4007, 2016 .
Snippet: These include regions near the genes SPINK6, EVC2, ARHGAP25, and DLGAP2 This study expands our understanding of human meiotic recombination by characterizing additional features that vary across individuals, and identifying regulatory variants influencing the numbers and locations of recombination events.
Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205 fbegum1@jhu.edu. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. Department of Neurology, University of California, Los Angeles, California 90095. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109. Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322. Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261. Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261. .
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3: Title: Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice.
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 197 (7): 2807-15, 2016 .
Snippet: In search for potential mechanisms of ARHGAP25-regulated migration of neutrophils, we detected an increase in the amount of active, GTP-bound Rac and Rac-dependent cytoskeletal changes in the absence of ARHGAP25, suggesting a critical role of ARHGAP25 in counterbalancing the Rac-activating effect of nucleotide exchange factors.
Affiliation: Department of Physiology, Semmelweis University, 1094 Budapest, Hungary; and Walter-Brendel-Zentrum für Experimentelle Medizin, Ludwig-Maximilians Universität, 80539 Munich, Germany. Department of Physiology, Semmelweis University, 1094 Budapest, Hungary; and. Walter-Brendel-Zentrum für Experimentelle Medizin, Ludwig-Maximilians Universität, 80539 Munich, Germany. Department of Physiology, Semmelweis University, 1094 Budapest, Hungary; and ligeti.erzsebet@med.semmelweis-univ.hu. .
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4: Title: The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity.
Authors: Thuault, Sylvie, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 27 (17): 2653-61, 2016 .
Snippet: Conversely, ARHGAP25, a GTPase-activating protein for Rac, was up-regulated in ARMS biopsies.
Affiliation: Université de Montpellier, CRBM, CNRS, UMR 5237, 34293 Montpellier, France sylvie.thuault@inserm.fr cecile.gauthier@crbm.cnrs.fr. Université de Montpellier, CRBM, CNRS, UMR 5237, 34293 Montpellier, France. Ligue Nationale Contre le Cancer, Cartes d'Identité des Tumeurs, 75013 Paris, France. .
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5: Title: Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization.
Authors: Wang, Leo D, et.al. .
Journal: Blood, Vol. 128 (11): 1465-74, 2016 .
Snippet: Using this platform, we identify ARHGAP25 as a novel regulator of HSPC mobilization and demonstrate that ARHGAP25 phosphorylation at serine 363 is an important modulator of its function.
Affiliation: Joslin Diabetes Center, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA; Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA; Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA; Department of Physiology, Semmelweis University, Budapest, Hungary; and. Joslin Diabetes Center, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA; Joslin Diabetes Center, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA. .
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6: Title: Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
Authors: Schlam, Daniel, et.al. .
Journal: Nature communications (Nat Commun), Vol. 6, 2015 .
Snippet: Through a screen of 62 RhoGAP-family members, we demonstrate that ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation.
Affiliation: Division of Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G1X8. Institute of Medical Science, University of Toronto, Faculty of Medicine, 1 King's College Circle, Toronto, Ontario, Canada M5S1A8. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G1X5. Keenan Research Centre for Biomedical Science, St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario, Canada M5B1T8. .
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7: Title: Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.
Authors: Jiang, Yi-Zhou, et.al. .
Journal: BMC genomics, Vol. 16, 2015 .
Snippet: Methylation-specific PCR (MSP) confirmed differential CpG methylation of HOXA genes, the ER stress gene ATF4, inflammatory regulator microRNA-10a and ARHGAP25 that encodes a negative regulator of Rho GTPases involved in cytoskeleton remodeling.
Affiliation: Department of Pathology & Laboratory Medicine and Institute for Medicine & Engineering, Perelman School of Medicine, University of Pennsylvania, 1010 Vagelos Building, 3340 Smith Walk, Philadelphia, PA, 19104, USA. jyizhou@mail.med.upenn.edu. Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. manduchi@upenn.edu. Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. stoeckrt@upenn.edu. Department of Pathology & Laboratory Medicine and Institute for Medicine & Engineering, Perelman School of Medicine, University of Pennsylvania, 1010 Vagelos Building, 3340 Smith Walk, Philadelphia, PA, 19104, USA. pfd@mail.med.upenn.edu. .
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8: Title: Role of Rac GTPase activating proteins in regulation of NADPH oxidase in human neutrophils.
Authors: Lőrincz, Ákos M, et.al. .
Journal: Free radical biology & medicine (Free Radic Biol Med), Vol. 68, 2014 .
Snippet: Depletion of membrane-associated RacGAPs had a selective effect: a decrease in ARHGAP1 or ARHGAP25 level increased O2(-) production but a depletion of ARHGAP35 had no effect.
Affiliation: Department of Physiology, Semmelweis University, Tűzoltó u. 37-47, 1094 Budapest, Hungary. Department of Biology and Physics, Kennesaw State University, 1000 Chastain Road, Building 12, Room 308, Kennesaw, GA 30144, USA. Department of Physiology, Semmelweis University, Tűzoltó u. 37-47, 1094 Budapest, Hungary. Electronic address: ligeti.erzsebet@med.semmelweis-univ.hu. .
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9: Title: Rho/RacGAPs: embarras de richesse?
Journal: Small GTPases, Vol. 3 (3): 178-82, 2012 Jul-Sep .
Snippet: In our recent study we investigated the first time ARHGAP25 at the protein level, determined its activity as RacGAP and showed its involvement in phagocytosis.
Affiliation: Department of Physiology, Semmelweis University, Budapest, Hungary. .
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10: Title: ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes.
Journal: Blood, Vol. 119 (2): 573-82, 2012 .
Snippet: By silencing and overexpressing the protein in neutrophil model cell lines (PLB-985 and CosPhoxFcγR, respectively) and in primary macrophages, we demonstrate that ARHGAP25 is a negative regulator of phagocytosis acting probably via modulation of the actin cytoskeleton.
Affiliation: Department of Physiology, Semmelweis University, Budapest, Hungary. .
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11: Title: Candidate epigenetic biomarkers for non-invasive prenatal diagnosis of Down syndrome.
Authors: Old, Robert W, et.al. .
Journal: Reproductive biomedicine online (Reprod Biomed Online), Vol. 15 (2): 227-35, 2007 .
Snippet: Differentially methylated sequences located at 21q22.3 (AIRE, SIM2 and ERG genes), 1q32.1 (CD48 gene and FAIM3 gene), 2p14 (ARHGAP25 gene) and 12q24 (SELPLG gene) were identified.
Affiliation: Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. r.w.old@warwick.ac.uk .
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12: Title: Identification and characterization of ARHGAP27 gene in silico.
Authors: Katoh, Yuriko, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 14 (5): 943-7, 2004 .
Snippet: ARHGAP1, ARHGAP2, ARHGAP3, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP7 (DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK3R2, and FNBP2 genes encode Rho/Rac/Cdc42-like GTPase activating (RhoGAP) proteins.
Affiliation: M&M Medical BioInformatics, Hongo 113-0033, Japan. .
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13: Title: Characterization of human ARHGAP10 gene in silico.
Authors: Katoh, Masuko, et.al. .
Journal: International journal of oncology (Int J Oncol), Vol. 25 (4): 1201-6, 2004 .
Snippet: ARHGAP gene family was found consisting of at least 32 members, including ARHGAP1, ARHGAP2 (CHN1), ARHGAP3, (CHN2), ARHGAP4, ARHGAP5, ARHGAP6 (STARD8), ARHGAP7 (STARD12 or DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STRAD13 (DLC2), HA-1, GMIP, PARG1, PIK3R1, PIK3R2, RACGAP1, and FNBP2.
Affiliation: M&M Medical BioInformatics, Narashino 275-0022, Japan. .
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14: Title: Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.
Authors: Katoh, Masuko, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 14 (2): 333-8, 2004 .
Snippet: and BM927439 type were derived from human ARHGAP25 gene due to alternative splicing (alternative promoter).
Affiliation: M&M Medical BioInformatics, Narashino 275-0022, Japan. .
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