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41 documents found
1: Title: Inhibition of macrophage migration inhibitory factor attenuates inflammation and fetal kidney injury in a rat model of acute pancreatitis in pregnancy.
Authors: Li, Man, et.al. .
Journal: International immunopharmacology (Int Immunopharmacol), Vol. 68, 2019 .
Snippet: The APIP rat model was induced by retrograde infusion of sodium taurocholate saline solution into biliopancreatic duct.
Affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: liman192@whu.edu.cn. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: yogaqq116@whu.edu.cn. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: zlnet@whu.edu.cn. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: zhouyu0723@whu.edu.cn. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: hongyupu@whu.edu.cn. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: sate.llite@163.com. .
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2: Title: Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis.
Authors: Wang, Chen-Yang, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 505 (3): 657-663, 2018 .
Snippet: The activities of serum amylase, lipase and levels of MDA, TNF-α and IL-1β were markedly increased in acute pancreatitis rats, the levels of serum FT3 and FT4 were obviously decreased in APIP groups, and the expressions of MIF, ICAM-1 and CD68 were significantly increased in the thyroid of the APIP group.
Affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, 430060, Hubei, China. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Electronic address: sate.llite@163.com. .
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3: Title: SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy.
Authors: Zhou, Yu, et.al. .
Journal: Inflammopharmacology, 2018 .
Snippet: Acute pancreatitis in pregnancy (APIP) can lead to multiple maternal and fetal organ injury and mitogen-activated protein kinase (MAPK) signaling pathway may be involved in it; however, whether APIP can result in acute lung injury and P38MAPK signaling pathway is involved in the pathogenesis has not been elucidated.
Affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, No.99 Zhang Zhidong Road, Wuhan, 430060, Hubei, China. Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Hubei Key Laboratory of Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Medical Examination Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Department of General Surgery, Renmin Hospital of Wuhan University, No.99 Zhang Zhidong Road, Wuhan, 430060, Hubei, China. sate.llite@163.com. .
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4: Title: Neutrophil-lymphocyte ratio, gamma-glutamyl transpeptidase, lipase, high-density lipoprotein as a panel of factors to predict acute pancreatitis in pregnancy.
Authors: Zhang, Lichun, et.al. .
Journal: Medicine (Medicine (baltimore)), Vol. 97 (26): e11189, 2018 .
Snippet: Multivariate logistic regression analysis was performed to investigate the relationship between various factors and APIP using Statistical Applied Software (SAS student version).Compared with normal pregnant women, APIP patients have elevated values in alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen, creatinine, C-reactive protein, direct bilirubin, fibrin degradation products, gamma-glutamyl transpeptidase (GGT), glucose, lipase, pH and decreased values in albumin, fibrinogen, high-density lipoprotein (HDL), hemoglobin, low-density lipoprotein cholesterol (LDL-D), and total proteins from their blood tests.
Affiliation: Department of Emergency, Shengjing Affiliated Hospital of China Medical University, Shenyang, Liaoning Province. CellWay Bio, ChangSha, Hunan, China. .
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5: Title: [Influence of acute pancreatitis in pregnancy on pregnancy outcomes and neonates].
Authors: Fan, Shu-Juan, et.al. .
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi), Vol. 20 (4): 274-278, 2018 .
Snippet: The incidence rates of neonatal respiratory distress syndrome, intracranial hemorrhage, and infectious disease were the lowest in the mild APIP group (P<0.05).
Affiliation: Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. liuli918@163.com. .
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6: Title: Macrophage migration inhibitory factor antagonist (S,R)3‑(4‑hydroxyphenyl)‑4,5‑dihydro‑5‑isoxazole acetic acid methyl ester attenuates inflammation and lung injury in rats with acute pancreatitis in pregnancy.
Authors: Zhou, Yu, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 17 (5): 6576-6584, 2018 .
Snippet: The present study was undertaken to clarify the effect and potential mechanism of MIF antagonist (S,R)3‑(4‑hydroxyphenyl)‑4,5‑dihydro‑5‑isoxazole acetic acid methyl ester (ISO‑1) in the development of acute lung injury in rats with APIP.
Affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China. .
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7: Title: What may cause fetus loss from acute pancreatitis in pregnancy: Analysis of 54 cases.
Authors: Tang, Min, et.al. .
Journal: Medicine (Medicine (baltimore)), Vol. 97 (7): e9755, 2018 .
Snippet: patients had fetal monitoring including non-stress test (NST); 1 case of SAP (14.3%) and 15 cases of MSAP (62.5%) were not transferred to intensive care unit for intensive monitoring.The incidence of fetal distress and fetal loss increased with worsening of APIP severity.
Affiliation: Department of Gastroenterology, the First Hospital of Anhui Medical University. Department of Gastroenterology, the Second Hospital of Anhui Medical University, Hefei, China. .
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8: Title: Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy.
Authors: Guo, Zheng-Da, et.al. .
Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res), 2017 .
Snippet: ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP.
Affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China. Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, China. Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. .
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9: Title: Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases.
Authors: Luo, Lingyu, et.al. .
Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet), 2017 .
Snippet: This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP).
Affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, No.17 Yongwai Zheng Street, Nanchang, 330006, China. Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, No.17 Yongwai Zheng Street, Nanchang, 330006, China. lunonghua@163.com. .
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10: Title: A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy.
Authors: Zhao, Liang, et.al. .
Journal: Pathology, research and practice (Pathol Res Pract), Vol. 213 (11): 1370-1377, 2017 .
Snippet: Our research suggests that fetal lung injury is involved in the rat model of APIP and that the dysregulated synthesis and secretion of pulmonary surfactant proteins play a critical role in fetal lung injury during APIP.
Affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, China; Key laboratory of Hubei Province for Digestive System Disease, 9 Zhangzhidong Road, Wuhan, Hubei Province 430060, China. Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, China. Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, China; Central Laboratory, Renmin Hospital of Wuhan University, 9 Zhangzhidong Road, Wuhan, Hubei Province 430060, China. Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, China. Electronic address: sate.llite@163.com. .
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11: Title: Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity.
Authors: Stolzenburg, Lindsay R, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 45 (15): 8773-8784, 2017 .
Snippet: One of these, at chromosome 11p13, is an intergenic region between Ets homologous factor (EHF) and Apaf-1 interacting protein (APIP).
Affiliation: Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, IL 60614, USA. Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44016, USA. .
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12: Title: Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.
Authors: Wang, Liuyang, et.al. .
Journal: Science advances (Sci Adv), Vol. 3 (3): e1602096, 2017 .
Snippet: Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients.
Affiliation: Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA. Duke Regional Hospital, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Duke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA. Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K.; Department of Paediatrics, University of Oxford, Oxford OX3 9DU, U.K. Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K. Proteomics and Metabolomics Core Facility, Duke University Medical Center, Durham, NC 27710, USA. Department of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA. Division of Laboratory Animal Resources, Duke University Medical Center, Durham, NC 27710, USA. Duke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.; Proteomics and Metabolomics Core Facility, Duke University Medical Center, Durham, NC 27710, USA. Kenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya. Kenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.; Department of Medicine, Imperial College, Norfolk Place, London W2 1PG, U.K. Kenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K. Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K.; Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, U.K. Duke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.; Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Medical Service, Durham Veterans Affairs Health Care System, Durham, NC 27705, USA. Duke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA. Duke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.; Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Emergency Medicine Service, Durham Veterans Affairs Health Care System, Durham, NC 27705, USA. Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. .
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13: Title: Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26.
Authors: Okuda, Takashi, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 13 (1): 215-221, 2017 .
Snippet: BRWD2, FGFR2 and ATE1 at chromosome 10q26, and 24 genes, including APIP, CD44, RAG1 and RAG2, at chromosome 11p13.
Affiliation: Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602-8566, Japan; Department of Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602-8566, Japan. Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602-8566, Japan. Department of Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602-8566, Japan. Department of Digestive Surgery, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602-8566, Japan. .
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14: Title: APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.
Authors: Hong, Se-Hoon, et.al. .
Journal: Oncotarget, Vol. 7 (16): 21601-17, 2016 .
Snippet: In response to HRG-β1, APIP binds to the ERBB3 receptor, leading to an enhanced binding of ERBB3 and ERBB2 that results in sustained activations of ERK1/2 and AKT protein kinases.
Affiliation: School of Biological Science, Seoul National University, Gwanak-gu, Seoul 151-747, Korea. Graduate School of East-West Medical Science, Kyung Hee University, Gyeoggi-Do 446-701, Korea. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea. Department of Surgery, Chonbuk National University Medical School, Jeonju 561-180, Korea. Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea. Department of Chemistry, College of Natural Sciences, Soongsil University, Seoul 156-743, Korea. .
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15: Title: Mitogen-Activated Protein Kinases Are Activated in Placental Injury in Rat Model of Acute Pancreatitis in Pregnancy.
Authors: Zuo, Teng, et.al. .
Journal: Pancreas, Vol. 45 (6): 850-7, 2016 .
Snippet: Serum levels of amylase and lipase significantly increased but Ca decreased; tumor necrosis factor-α, IL-1β, IL-6, and IL-10 were all increased in the APIP group; c-Jun N-terminal kinase, p38, and ERK1/2 were activated but with different distributing patterns in the placenta.
Affiliation: From the Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. .
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16: Title: Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.
Authors: Corvol, Harriet, et.al. .
Journal: Nature communications (Nat Commun), Vol. 6, 2015 .
Snippet: The fifth locus, on chr11p12-p13 (EHF/APIP; P=1.9 × 10(-10)), was previously shown to be associated with lung disease.
Affiliation: Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Trousseau, Pediatric Pulmonary Department; Institut National de la Santé et la Recherche Médicale (INSERM) U938, Paris 75012, France. Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Paris 75005, France. Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. AP-HP, Hôpital St Antoine, Biostatistics Department; Inserm U1136, Paris 75012, France. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Marsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Center, Aurora, Colorado 80045, USA. Children's Hospital Colorado, Anschutz Medical Center, Aurora, Colorado 80045, USA. Department of Pediatrics, School of Medicine, Anschutz Medical Center, Aurora, Colorado 80045, USA. Division of Pediatric Pulmonology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 0A4. Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 0A4. Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3G3. Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada M5T 3M7. Bioinformatics Research Center and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, USA. Division of Pulmonary Medicine, Department of Pediatrics, Stanley Manne Research Institute, Northwestern University Feinberg School of Medicine, Ann and Robert Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA. Department of Pediatrics, University of Toronto, Toronto, Ontario M5G 1X8, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8. Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. Bioinformatics Research Center and Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, USA. Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, USA. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. .
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17: Title: A 23-year, single-center, retrospective analysis of 36 cases of acute pancreatitis in pregnancy.
Authors: Xu, Qiuxiang, et.al. .
Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet), Vol. 130 (2): 123-6, 2015 .
Snippet: METHODS: A retrospective review was conducted of the medical records of pregnant women who were diagnosed with APIP at any point during pregnancy, labor, or the puerperium and attended Beijing Chaoyang Hospital, China, between January 1, 1991, and March 31, 2014.
Affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: zhenyuzhang2014@126.com. .
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18: Title: CD44-SLC1A2 fusion transcripts in primary colorectal cancer.
Authors: Shinmura, Kazuya, et.al. .
Journal: Pathology oncology research : POR (Pathol Oncol Res), Vol. 21 (3): 759-64, 2015 .
Snippet: A CD44-SLC1A2 fusion has recently been discovered in a subset of primary gastric cancers, and an APIP-SLC1A2 fusion has been described in a colon cancer cell line (SNU-C1); however, whether such SLC1A2 fusions occur in primary colorectal cancer (CRC) and whether such fusions are specific for gastrointestinal cancers remain uncertain.
Affiliation: Department of Tumor Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka, 431-3192, Japan, kzshinmu@hama-med.ac.jp. .
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19: Title: Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity--a short report.
Authors: Oh, Hye Rim, et.al. .
Journal: Cellular oncology (Dordrecht) (Cell Oncol (dordr)), Vol. 37 (6): 455-61, 2014 .
Snippet: RESULTS: Using SSCP in conjunction with DNA sequencing we detected frameshift mutations in AGXT (17 cases), ALDH2 (3 cases), APIP (4 cases), MTR (5 cases), DNMT1 (1 case), ASH1L (1 case), ASPA (2 cases), CAD (2 cases), DDC (1 case), GCDH (3 cases), DLD (1 case), LAP3 (1 case), MCEE (5 cases) and MUT (1 case).
Affiliation: Departments of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, South Korea. .
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20: Title: Network analysis in the identification of special mechanisms between small cell lung cancer and non-small cell lung cancer.
Authors: Zhang, Weisan, et.al. .
Journal: Thoracic cancer (Thorac Cancer), Vol. 5 (6): 556-64, 2014 .
Snippet: Moreover, a potential biomarker of SCLC is the interaction between APIP and apoptotic protease activating factor (APAF)1, which share a common module.
Affiliation: Department of Geriatrics, Tianjin Geriatric Institute, Tianjin Medical University General Hospital Tianjin, China. Department of Radiology, Tianjin Medical University General Hospital Tianjin, China. .
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