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16 documents found
1: Title: PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.
Authors: Varagnolo, Linda, .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Human CB-derived CD34+ cells were cultured in serum-free medium together with SCF, TPO, FGF, with or without Igfbp2 and Angptl5 (STF/STFIA cocktails).
Affiliation: Institute of Medical Radiology and Cell Research (MSZ) in the Center for Experimental Molecular Medicine (ZEMM), University of Würzburg, Würzburg, Germany. Department of Cell Biology, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom. Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany. Department of Gynecology and Obstetrics, Medical University of Würzburg, Germany. 1] Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany [2] Department of Medicine, Div. Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany. .
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2: Title: Identification of stage-specific biomarkers in lung adenocarcinoma based on RNA-seq data.
Authors: Liang, Jun, .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 36 (8): 6391-9, 2015 .
Snippet: ANGPTL5, C7orf16, EDN3, LOC150622, HOXA11AS, IL1F5, and USH1G significantly distinguished stage III from stages I and II.
Affiliation: Department of Oncology, The Affilicated Hospital of Qingdao University, No.16 Jiangsu Road, Shinan District, Qingdao, 266000, Shandong Province, China, .
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3: Title: Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer.
Authors: Wang, Linlin, .
Journal: Molecular medicine reports (Mol Med Report), Vol. 11 (4): 2789-96, 2015 .
Snippet: By contrast, in the ILT4‑negative cases, no statistically significant differences were identified in the overall survival rates between samples with high and low expression of ANGPTL2 or ANGPTL5.
Affiliation: Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China. Department of Oncology, Weifang Medical University, Weifang, Shandong 261053, P.R. China. Department of Pathophysiology, Medicine School of Shandong University, Jinan, Shandong 250012, P.R. China. Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China. .
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4: Title: Detecting rare variant effects using extreme phenotype sampling in sequencing association studies.
Authors: Barnett, Ian J, .
Journal: Genetic epidemiology (Genet Epidemiol), Vol. 37 (2): 142-51, 2013 .
Snippet: We confirm both analytically and numerically that sampling individuals with extreme phenotypes can enrich the presence of causal rare variants and can therefore lead to an increase in power compared to random sampling.
Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. .
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5: Title: Adaptive ridge regression for rare variant detection.
Authors: Zhan, Haimao, .
Journal: PloS one, Vol. 7 (8): e44173, 2012 .
Snippet: Advances in high-throughput DNA sequencing technologies allow us to genotype rare causal variants and investigate the effects of such rare variants on complex traits.
Affiliation: Department of Botany and Plant Sciences, University of California Riverside, Riverside, California, USA. .
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6: Title: A novel genome-information content-based statistic for genome-wide association analysis designed for next-generation sequencing data.
Authors: Luo, Li, .
Journal: Journal of computational biology : a journal of computational molecular cell biology (J Comput Biol), Vol. 19 (6): 731-44, 2012 .
Snippet: Finally, we apply the seven statistics to published resequencing dataset from ANGPTL3, ANGPTL4, ANGPTL5, and ANGPTL6 genes in the Dallas Heart Study.
Affiliation: Human Genetics Center, School of Public Health, University of Texas, Houston, TX, USA. .
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7: Title: Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells.
Authors: Blank, Ulrika, .
Journal: European journal of haematology (Eur J Haematol), Vol. 89 (3): 198-205, 2012 .
Snippet: CONCLUSION: Our findings indicate that Angptl4 and Angptl5 can lead to increased engraftment capacity of SRCs, but more frequently, these factors are associated with maintenance of SRC activity during ex vivo culture.
Affiliation: Division of Molecular Medicine and Gene Therapy, Laboratory Medicine, Lund Stem Cell Center, Lund University Hospital, Lund, Sweden. .
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8: Title: Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice.
Authors: Drake, Adam C, .
Journal: PloS one, Vol. 6 (4): e18382, 2011 .
Snippet: Here, we expanded cord blood CD34(+) CD133(+) cells in a defined medium containing angiopoietin like 5 and insulin-like growth factor binding protein 2 and evaluated the cells for stem cell activity in NOD-SCID Il2rg(-/-) (NSG) mice by multi-lineage engraftment, long term reconstitution, limiting dilution and serial reconstitution.
Affiliation: Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. .
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9: Title: Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential.
Authors: Khoury, Maroun, .
Journal: Stem cells and development (Stem Cells Dev), Vol. 20 (8): 1371-81, 2011 .
Snippet: Here, we report a robust HSC coculture system wherein cord blood CD34(+) CD133(+) cells were cocultured with mesenchymal stem cells engineered to express angiopoietin-like-5 in a defined medium.
Affiliation: Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. .
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10: Title: A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions.
Authors: Liu, Dajiang J, .
Journal: PLoS genetics (Plos Genet), Vol. 6 (10): e1001156, 2010 .
Snippet: To evaluate the power of KBAC: 1) variant data was simulated using rigorous population genetic models for both Europeans and Africans, with parameters estimated from sequence data, and 2) phenotypes were generated using models motivated by complex diseases including breast cancer and Hirschsprung's disease.
Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA. .
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11: Title: Ontogeny of angiopoietin-like protein 1, 2, 3, 4, 5, and 7 genes during chick embryonic development.
Authors: Niki, Daisuke, .
Journal: Development, growth & differentiation (Dev Growth Differ), Vol. 51 (9): 821-32, 2009 .
Snippet: Angptl5 was not detected in these developmental stages.
Affiliation: Division of Organogenesis, Department of Pattern Formation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto, Japan. .
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12: Title: Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events.
Authors: Miida, Takashi, .
Journal: Current opinion in lipidology (Curr Opin Lipidol), Vol. 21 (1): 70-5, 2010 .
Snippet: SUMMARY: Angptl3, Angptl4, and possibly Angptl5 are regulators of lipoprotein metabolism in humans.
Affiliation: Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. .
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13: Title: Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.
Authors: Romeo, Stefano, .
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 119 (1): 70-9, 2009 .
Snippet: Thus, ANGPTL3, ANGPTL4, and ANGPTL5, but not ANGPTL6, play nonredundant roles in TG metabolism, and multiple alleles at these loci cumulatively contribute to variability in plasma TG levels in humans.
Affiliation: Donald W. Reynolds Cardiovascular Clinical Research Center and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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14: Title: Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation.
Authors: Zhang, Cheng Cheng, .
Journal: Blood, Vol. 111 (7): 3415-23, 2008 .
Snippet: A serum-free medium containing SCF, TPO, and FGF-1 or Flt3-L cannot significantly support expansion of the SRCs present in human cord blood CD133+ cells.
Affiliation: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. .
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15: Title: Comparative integromics on Angiopoietin family members.
Authors: Katoh, Yuriko, .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 17 (6): 1145-9, 2006 .
Snippet: Angiopoietin family consists of ANGPT1, ANGPT2, ANGPT4, ANGPTL1 (ANGPT3), ANGPTL2, ANGPTL3 (ANGPT5), ANGPTL4, ANGPTL5, ANGPTL6 and ANGPTL7.
Affiliation: M&M Medical BioInformatics, Hongo, Japan. .
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16: Title: Identification of a novel human angiopoietin-like gene expressed mainly in heart.
Authors: Zeng, Li, .
Journal: Journal of human genetics (J Hum Genet), Vol. 48 (3): 159-62, 2003 .
Snippet: During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 ( ANGPTL5).
Affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China. .
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