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5 documents found
1: Title: Cross-protective Salmonella vaccine reduces cecal and splenic colonization of multidrug-resistant Salmonella enterica serovar Heidelberg.
Authors: Bearson, Shawn M D, et.al. .
Journal: Vaccine, Vol. 37 (10): 1255-1259, 2019 .
Snippet: Transcriptional analysis of whole blood from BBS 866-vaccinated turkeys revealed down-regulation of metabolic and immune genes (KCNAB1, ACOD1, GPR17, ADOR2AB, and IL-17RD), suggesting limited leukocyte activation without an overt peripheral inflammatory response to vaccination.
Affiliation: USDA, ARS, National Animal Disease Center, Ames, IA, United States. Electronic address: shawn.bearson@ars.usda.gov. USDA, ARS, National Laboratory for Agriculture and the Environment, Ames, IA, United States. USDA, ARS, National Animal Disease Center, Ames, IA, United States. USDA, ARS, Food and Feed Safety Research, College Station, TX, United States. .
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2: Title: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Authors: Mills, Evanna L, et.al. .
Journal: Nature, 2018 .
Snippet: We show that type I interferons boost the expression of Irg1 (also known as Acod1) and itaconate production.
Affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK. MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK. Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK. MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK. Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK. GlaxoSmithKline, Park Road, Ware, Hertfordshire, UK. Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany. WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. .
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3: Title: GOTcha: lncRNA-ACOD1 targets metabolism during viral infection.
Authors: Runtsch, Marah C, et.al. .
Journal: Cell research (Cell Res), 2017 .
Snippet: A recent report in Science demonstrates a mechanistic role for a novel lncRNA in directly binding an essential metabolic enzyme, glutamic-oxaloacetic transaminase (GOT2); this interaction benefits viral replication via alteration of host metabolism.
Affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. .
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4: Title: An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism.
Authors: Wang, Pin, et.al. .
Journal: Science (New York, N.Y.) (Science), Vol. 358 (6366): 1051-1055, 2017 .
Snippet: In vivo deficiency of lncRNA-ACOD1 (a lncRNA identified by its nearest coding gene Acod1, aconitate decarboxylase 1) significantly attenuates viral infection through IFN-I-IRF3 (interferon regulatory factor 3)-independent pathways.
Affiliation: National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China. National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China. caoxt@immunol.org. Department of Immunology and Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China. .
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5: Title: Expression pattern of XIRG, a marker for non-neural ectoderm.
Authors: Schmidt, G, et.al. .
Journal: Development genes and evolution (Dev Genes Evol), Vol. 210 (11): 575-8, 2000 .
Snippet: Mouse IRG1 mRNA is expressed in cultured macrophages as a response to bacterial lipopolysaccharide treatment.
Affiliation: Institute of Genetics and General Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria. georg.schmidt@sbg.ac.at .
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