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WD repeat domain 3

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin-Like Growth Factor I, p53, ACID, CAN, POLYMERASE
Papers on WDR3
Possible role of the WDR3 gene on genome stability in thyroid cancer patients.
Marcos et al., Barcelona, Spain. In Plos One, 2011
The role of the WDR3 gene on genomic instability has been evaluated in a group of 115 differentiated thyroid cancer (DTC) patients.
WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.
Velázquez et al., Barcelona, Spain. In Thyroid, 2010
results indicate for the first time that WDR3 is a risk factor to thyroid cancer, suggesting its implication in the etiology of thyroid cancer
Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.
O'Connor et al., Cork, Ireland. In J Biol Chem, 2010
WDR3 has an essential function in 40 S ribosomal subunit synthesis and in ribosomal stress signaling to p53-mediated regulation of cell cycle progression in cancer cells
Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13.
Hawley et al., Toronto, Canada. In Genomics, 1999
We report here the isolation of a new member of the WD repeat gene family, WDR3, which encodes a putative 943-amino-acid nuclear protein consisting of 10 WD repeat modules.
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