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WD repeat and FYVE domain containing 1

WDFY1, Phosphoinositide binding protein, FENS-1
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains a single FYVE domain and multiple WD40 repeats. This protein is localized to endosomes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, neuropilin-2, TLR3, TRAM, SET
Papers on WDFY1
Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology.
Datta et al., Dresden, Germany. In Cancer Res, Feb 2016
Mechanistic investigations revealed that WD-repeat- and FYVE-domain-containing protein 1 (WDFY1) functioned downstream of NRP2 to promote endosome maturation, thereby influencing the endosomal trafficking of EGFR and the formation of autolysosomes responsible for the degradation of internalized cargo.
WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
Liu et al., Wuhan, China. In Embo Rep, Apr 2015
Here, we identify the WD repeat and FYVE-domain-containing protein WDFY1 as a crucial adaptor protein in the TLR3/4 signaling pathway.
Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway.
Paludan et al., Århus, Denmark. In Embo Rep, Apr 2015
In this issue of EMBO Reports, Hu and colleagues report that WD-repeat and FYVE-domain-containing protein 1 (WDFY1) recruits the signaling adaptor TRIF to TLR3 and TLR4, thereby potentiating signaling from these PRRs (Fig 1); [2].
Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells.
Gasiewicz et al., Rochester, United States. In Plos One, 2014
We verified differential expression of PDGF-D, Smo, Wdfy1, Zbtb37 and Zfp382.
Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.
Auburger et al., In Neurogenetics, 2014
Novel and surprisingly strong expression alterations were detected for fat storage and membrane trafficking factors, with prominent +3-fold upregulations of Plin4, Wdfy1, Tbc1d24, and Pnpla2 vs. a −2.4-fold downregulation of Cntn4 transcript, encoding an axonal membrane adhesion factor with established haploinsufficiency.In comparison, subtle effects on the RNA processing machinery included up to 1.2-fold upregulations of Dcp1b and Tial1.
Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.
Neuschwander-Tetri et al., Saint Louis, United States. In Am J Pathol, 2013
Genes with differentially regulated expression between the two substrains that might be candidates in CP progression included Mmp7, Pcolce2, Itih4, Wdfy1, and Vtn.
Angiogenic growth factor axis in autophagy regulation.
Datta et al., Omaha, United States. In Autophagy, 2013
While examining the molecular mechanisms involved in this survival, we performed a microarray study in which we identified two genes, WDFY1 and LAMP2, which have been suggested to function in autophagy.
Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: mining of microarray data by logic classification and feature selection.
Cattaneo et al., Roma, Italy. In J Alzheimers Dis, 2010
We selected three differential "signature" genes specific for the early stage (Nudt19, Arl16, Aph1b), five common to both groups (Slc15a2, Agpat5, Sox2ot, 2210015, D19Rik, Wdfy1), and seven specific for late stage (D14Ertd449, Tia1, Txnl4, 1810014B01Rik, Snhg3, Actl6a, Rnf25).
Membrane insertion of the FYVE domain is modulated by pH.
Kutateladze et al., Aurora, United States. In Proteins, 2009
Lowering the pH enhances the interaction of the Hrs, RUFY1, Vps27p and WDFY1 FYVE domains with PtdIns(3)P-containing membranes in vitro and in vivo, indicating that pH-dependency is a general function of the FYVE finger family.
Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.
Robertson et al., Adelaide, Australia. In Biol Reprod, 2009
Microarray and quantitative RT-PCR analyses on Embryonic Day (E) 13 placentae revealed that the Csf2 null mutation caused altered expression of 17 genes not previously known to be associated with placental development, including Mid1, Cd24a, Tnfrsf11b, and Wdfy1.
Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains.
Bergeson et al., Austin, United States. In Genes Brain Behav, 2008
H2afz, Psen1, Wdfy1 and Clu were also identified as candidate genes that may be involved in influencing alcohol consumption.
Alternative splicing and bioinformatic analysis of human U12-type introns.
Tarn et al., Taiwan. In Nucleic Acids Res, 2006
In addition, we examined the effects of single nucleotide polymorphisms in the human WDFY1 U12-type intron on pre-mRNA splicing.
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.
Hawkins et al., Cambridge, United Kingdom. In J Cell Sci, 2001
FENS-1 and DFCP1 are recently discovered proteins containing one or two FYVE-domains respectively.
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