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WAS protein family, member 1

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, Wasp, Arp2, CAN, Akt
Papers using WAVE antibodies
Contact-dependent promotion of cell migration by the OL-protocadherin–Nap1 interaction
Takeichi Masatoshi et al., In The Journal of Cell Biology, 2006
... The WAVE1 expression vector cloned into pEGFP (Clontech Laboratories, Inc.) was provided ...
Papers on WAVE
Decreased expression of cortactin in the schizophrenia brain.
Meador-Woodruff et al., New York City, United States. In Neuroreport, Jan 2016
To determine whether the Arp2/3 complex is abnormally expressed in schizophrenia, we measured the protein expression of Arp2 and Arp3, as well as Arp2/3 complex binding partners and associated proteins including cortactin, neuronal-Wiskott-Aldrich syndrome protein (WASP), WASP-family verprolin homologous protein 1 (WAVE1), and Abelson interactor 1 (Abi1) in the superior temporal gyrus of paired schizophrenia and comparison participants.
WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development.
Bogdan et al., Münster, Germany. In J Cell Sci, Jan 2016
In Drosophila, three different family members, SCAR/WAVE, WASP and WASH, have been analyzed so far.
Clinical significance and expression of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer.
Azizmohammadi et al., Tehrān, Iran. In Tumour Biol, Jan 2016
UNASSIGNED: In this study, we evaluate the clinical significance of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) in patients with epithelial ovarian cancer (EOC) by immunohistochemistry.In current study, all adjacent non-cancerous tissues showed absent or low expression of PRSS3.
SCARN a Novel Class of SCAR Protein That Is Required for Root-Hair Infection during Legume Nodulation.
Xie et al., Shanghai, China. In Plos Genet, Oct 2015
In the SCAR/WAVE (Suppressor of cAMP receptor defect/WASP family verpolin homologous protein) actin regulatory complex, the conserved N-terminal domains of SCAR proteins interact with other components of the SCAR/WAVE complex.
APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
Kim et al., New York City, United States. In Nat Med, Sep 2015
Here we report that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1 or WASF1) as part of a negative feedback mechanism to limit Aβ production.
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases.
Golemis et al., Philadelphia, United States. In Gene, Sep 2015
Downstream, NEDD9 regulation of partners including CRKL, WAVE, PI3K/AKT, ERK, E-cadherin, Aurora-A (AURKA), HDAC6, and others allow NEDD9 to influence functions as pleiotropic as migration, invasion, survival, ciliary resorption, and mitosis.
Signaling networks that regulate cell migration.
Horwitz et al., Charlottesville, United States. In Cold Spring Harb Perspect Biol, Aug 2015
Their effectors include actin regulators such as formins, members of the WASP/WAVE family and the Arp2/3 complex, and the myosin II motor protein.
MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion.
Bagni et al., Leuven, Belgium. In J Chem Theory Comput, Aug 2015
Cytoplasmic FMRP interacting protein 1 (CYFIP1), also known as specifically RAC1 activated protein 1 (Sra1), plays a dual role: together with fragile X mental retardation protein (FMRP) and eIF4E it forms a complex that inhibits mRNA translation, while together with WAVE1, NCKAP1, ABI2, and HSPC300 it forms the WAVE regulatory complex (WRC) that upon RAC1 activation initiates actin polymerization.
Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis.
Martin et al., Cardiff, United Kingdom. In Breast Cancer (london), 2014
The Wiskott-Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of molecules that form a key link between GTPases and the actin cytoskeleton.
Cyclosporine A protects podocytes by regulating WAVE1 phosphorylation.
Ding et al., Beijing, China. In Sci Rep, 2014
Previous studies showed that calcineurin can directly regulate WAVE1 within mouse striatal slices.
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.
Gautreau et al., Gif-sur-Yvette, France. In Nat Rev Mol Cell Biol, 2014
Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin-homologous protein) complex and Arpin, respectively) and of proteins that control actin branch stability (such as glial maturation factor (GMF)) or actin filament elongation (such as ENA/VASP proteins) in lamellipodium dynamics and cell migration.
Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
Ming et al., Baltimore, United States. In Cell Stem Cell, 2014
In developing mouse cortex, deficiency in CYFIP1 and WAVE signaling similarly affects radial glial cells, leading to their ectopic localization outside of the ventricular zone.
Structure and role of WASP and WAVE in Rho GTPase signalling in cancer.
Jiang et al., Cardiff, United Kingdom. In Cancer Genomics Proteomics, 2014
The present review explores the role and function of Rho GTPases, WASP and WAVE in cancer metastasis.
Local F-actin network links synapse formation and axon branching.
Shen et al., Stanford, United States. In Cell, 2014
We further find that assembly of the F-actin network requires a direct interaction between the synaptic cell adhesion molecule SYG-1 and a key regulator of actin cytoskeleton, the WVE-1/WAVE regulatory complex (WRC).
The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.
Rosen et al., Dallas, United States. In Cell, 2014
The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane sites.
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.
Kiernan et al., Montpellier, France. In Cell, 2012
Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR.
Inflammatory radiculoneuropathy in an ALS4 patient with a novel SETX mutation.
Kira et al., In J Neurol Neurosurg Psychiatry, 2012
novel missense mutation c.6406C>T (p.R2136C) in a patient with inflammatory radiculoneuropathy and amyotrophic lateral sclerosis
SETX gene mutation in a family diagnosed autosomal dominant proximal spinal muscular atrophy.
Zerres et al., Aachen, Germany. In Neuromuscul Disord, 2012
This sstudy descibed that SETX gene mutation in a family diagnosed autosomal dominant proximal spinal muscular atrophy.
Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins.
Parkhurst et al., Seattle, United States. In Dev Dyn, 2012
Wash, WASp, SCAR, and Whamy are dynamically expressed throughout oogenesis and embryogenesis.
mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.
Ahmed et al., Singapore, Singapore. In J Biol Chem, 2012
mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia.
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