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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Charged multivesicular body protein 5

Vps60, Mos10, PNAS-2, CHMP5, Vps60p
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Vps4, LIP5, ATPase, Snf7, V1a
Papers on Vps60
Cell layer-specific distribution of transiently expressed barley ESCRT-III component HvVPS60 in developing barley endosperm.
Ibl et al., Vienna, Austria. In Protoplasma, Jan 2016
We used fluorescently tagged core ESCRT-III members HvSNF7a/CHMP4 and HvVPS24/CHMP3 and the associated ESCRT-III component HvVPS60a/CHMP5 for transient localization studies in barley endosperm.
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts.
Shim et al., Seoul, South Korea. In J Exp Med, Aug 2015
Here, we demonstrate that modulation of NF-κB signaling in osteoclasts via a novel activity of charged multivesicular body protein 5 (CHMP5) is a key determinant of systemic rates of bone turnover.
A site-specific ecological risk assessment for corn-associated insecticides.
Lydy et al., Carbondale, United States. In Integr Environ Assess Manag, Jul 2015
In the risk characterization section of the ERA, stressor-response profiles for each species tested were compared with field distributions of the insecticides, and a margin of safety at the 10th percentile (MOS10) was calculated to estimate risk.
A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5.
Xu et al., Ann Arbor, United States. In J Biol Chem, Apr 2015
The N-terminal domain of LIP5 (LIP5NTD) is required for LIP5-mediated stimulation of VPS4, and the ESCRT-III protein CHMP5 strongly inhibits the stimulation.
A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche.
Riechmann et al., Mannheim, Germany. In J Cell Sci, 2014
We validated the significance of our screen by generating mutants for Vps60, a component of the endosomal sorting complexes required for transport (ESCRT) machinery.
¹H, ¹³C and ¹⁵N resonance assignments of the N-terminal domain of Vta1-Vps60 peptide complex.
Cao et al., Shanghai, China. In Biomol Nmr Assign, 2013
Vta1 and Vps60 are two ESCRT associated proteins, their direct interaction enhances Vps4 ATPase activity.
Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element.
Katzmann et al., Rochester, United States. In J Biol Chem, 2013
The VSE is also required for Vta1-mediated Vps4 stimulation by ESCRT-III subunits Vps60 and Did2.
Spatio-temporal distributions and the ecological and health risks of phthalate esters (PAEs) in the surface water of a large, shallow Chinese lake.
Xu et al., Beijing, China. In Sci Total Environ, 2013
The DnBP had much greater ecological risks than the other studied PAE congeners as indicated by its potential affected fractions (PAFs) and the margin of safety (MOS10).
The role of charged multivesicular body protein 5 in programmed cell death in leukemic cells.
Pan et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2013
The Homo sapiens charged multivesicular body protein 5 (CHMP5) is a member of the multivesicular body, which serves as an anti-apoptotic protein and is thought to participate in leukemogenesis.
Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.
Xu et al., Shanghai, China. In J Biol Chem, 2013
Vps4 activity is stimulated by the interaction between Vta1 and Vps60, but the structural basis for this interaction is unclear.
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport.
Sundquist et al., Salt Lake City, United States. In J Biol Chem, 2013
In contrast, the second LIP5 MIT module binds with unusually high affinity to a novel MIM element within the ESCRT-III protein CHMP5.
Anti-CHMP5 single chain variable fragment antibody retrovirus infection induces programmed cell death of AML leukemic cells in vitro.
Pan et al., Shanghai, China. In Acta Pharmacol Sin, 2012
AIM: Over-expressed CHMP5 was found to act as oncogene that probably participated in leukemogenesis.
Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B.
Xiao et al., Bethesda, United States. In Structure, 2012
Unexpectedly, CHMP5 was also found to bind Brox and specifically recruit endogenous Brox to detergent-resistant membrane fractions through its C-terminal 20 residues.
Interactome of the plant-specific ESCRT-III component AtVPS2.2 in Arabidopsis thaliana.
Hauser et al., Vienna, Austria. In J Proteome Res, 2012
Therefore we propose that at least in plants the large ESCRT-III membrane scaffolding complex consists of a mixture of SNF7, VPS2 and the associated VPS46 and VPS60 proteins.
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
Leis et al., Chicago, United States. In J Virol, 2011
ISG15 is conjugated to two different LIP5-ESCRT-III-binding charged multivesicular body proteins, CHMP2A and CHMP5.
[Expression spectra of apoptosis-related gene pnas-2].
Ouyan et al., Shanghai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2008
pnas-2 is specifically up-regulated in acute leukemia patients.
[Correlation between expression of apoptosis-related gene pnas-2 and leukemia].
Chen et al., Shanghai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007
The pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells.
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
Ghosh et al., New Haven, United States. In J Cell Biol, 2006
CHMP5 regulates late endosome function downstream of MVB formation, and the loss of CHMP5 enhances signal transduction by inhibiting lysosomal degradation of activated receptors.
PNAS-2: a novel gene probably participating in leukemogenesis.
Ouyang et al., Shanghai, China. In Oncology, 2005
PNAS-2 was shown to be anti-apoptotic and may participate in leukemogenesis
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