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Vacuolar protein sorting 4 homolog A

Vps4, Vps4p, SKD1, VPS4B
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, CAN, TSG101, V1a, Snf7
Papers using Vps4 antibodies
ALG-2 interacting protein AIP1: A novel link between D1 and D3 signalling
Trejo JoAnn et al., In The Journal of Cell Biology, 2007
... Polyclonal CHMP4A and CHMP4B antibodies as well as monoclonal anti-ALIX (3A9) and anti-Vps4 antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Cryosectioning and immunolabeling.
Cullen Bryan R., In PLoS Pathogens, 2006
... HRS and VPS4 cDNA were cloned into pEGFP-C vector (Clontech, France) ...
Papers on Vps4
Subviral hepatitis B virus filaments are released like infectious viral particles via multivesicular bodies.
Hildt et al., Langen, Germany. In J Virol, Jan 2016
Inhibition of MVB biogenesis by the small molecule inhibitior U18666A or inhibition of ESCRT-functionality by coexpression of transdominant negative mutants (Vps4A, Vps4B, CHMP3) abolishs the release of filaments while secretion of spheres is not affected.
The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.
Klein et al., Düsseldorf, Germany. In Plos Genet, Dec 2015
We could show that CC2D1A and its interaction partner CHMP4B are localised on endosomes in MEF cells, when the activity of the endosomal protein VPS4 is reduced.
ESCRT (Endosomal Sorting Complex Required for Transport) Machinery Is Essential for Acrosomal Exocytosis in Human Sperm.
Mayorga et al., Mendoza, Argentina. In Biol Reprod, Nov 2015
We report here that members of ESCRT I (TSG101), ESCRT III (CHMP4), and the AAA ATPase VPS4 are present in the acrosomal region of the human sperm.
Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants.
Nagy et al., Lexington, United States. In Virology, Oct 2015
We provide evidence that Rad6p is involved in promoting the subversion of Vps23p and Vps4p ESCRT proteins for viral replicase complex assembly.
A Critical Role of Lyst-Interacting Protein5, a Positive Regulator of Multivesicular Body Biogenesis, in Plant Responses to Heat and Salt Stresses.
Chen et al., Hangzhou, China. In Plant Physiol, Sep 2015
We have recently shown that Arabidopsis (Arabidopsis thaliana) Lyst-Interacting Protein5 (LIP5), a positive regulator of the Suppressor of K(+) Transport Growth Defect1 (SKD1) AAA ATPase in MVB biogenesis, is a critical target of the mitogen-activated protein kinases MPK3 and MPK6 and plays an important role in the plant immune system.
Marburg virus inclusions: A virus-induced microcompartment and interface to multivesicular bodies and the late endosomal compartment.
Becker et al., Marburg an der Lahn, Germany. In Eur J Cell Biol, Jul 2015
We detected additional proteins (Alix, Nedd4 and the AAA-type ATPase VPS4) of the endosomal sorting complex required for transport (ESCRT) that are recruited into inclusions.
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
Stenmark et al., Oslo, Norway. In Nature, Jul 2015
ESCRT-III and its regulatory AAA (ATPase associated with diverse cellular activities) ATPase VPS4 are specifically recruited by the ESCRT-III-like protein CHMP7 to sites where the reforming nuclear envelope engulfs spindle microtubules.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
Stenmark et al., Oslo, Norway. In Nat Cell Biol, 2014
Here we describe ANCHR (Abscission/NoCut Checkpoint Regulator; ZFYVE19) as a key regulator of the abscission checkpoint, functioning through the most downstream component of the ESCRT machinery, the ATPase VPS4.
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
Dustin et al., New York City, United States. In Nature, 2014
Tumour susceptibility gene 101 (TSG101) sorts TCRs for inclusion in microvesicles, whereas vacuolar protein sorting 4 (VPS4) mediates scission of microvesicles from the T-cell plasma membrane.
A pathogenic picornavirus acquires an envelope by hijacking cellular membranes.
Lemon et al., Chapel Hill, United States. In Nature, 2013
Their biogenesis is dependent on host proteins associated with endosomal-sorting complexes required for transport (ESCRT), namely VPS4B and ALIX.
Membrane fission reactions of the mammalian ESCRT pathway.
Sundquist et al., Salt Lake City, United States. In Annu Rev Biochem, 2012
The core ESCRT machinery comprises Bro1 family proteins and ESCRT-I, ESCRT-II, ESCRT-III, and VPS4 complexes.
[Cellular ESCRT complex and its roles in enveloped viruses budding].
Liu et al., China. In Sheng Wu Gong Cheng Xue Bao, 2012
Many retroviruses and RNA viruses encode "late-domain" motifs that are able to interact with the components of the ESCRT complex, and the interactions recruit ESCRT-III and VPS4 to the viral assembly and budding sites.
Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia.
Ann et al., Duarte, United States. In Mol Cell Biol, 2012
An inverse correlation between VPS4B expression and EGFR abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression.
Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component.
Lamb et al., München, Germany. In Nat Cell Biol, 2011
These results indicate that VPS4A has a direct role in membrane scission leading to HIV-1 release.
Divergent pathways lead to ESCRT-III-catalyzed membrane fission.
Weissenhorn et al., Bristol, United Kingdom. In Trends Biochem Sci, 2011
Although receptor sorting at the endosomal membrane producing MVBs employs the regulated assembly of ESCRT-0 followed by ESCRT-I, -II, -III and the vacuolar protein sorting (VPS)4 complex, other ESCRT-catalyzed processes require only a subset of complexes which commonly includes ESCRT-III and VPS4.
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.
Takeda et al., Sendai, Japan. In Plos One, 2010
VPS4, a master regulator of MVB sorting, may serve as a determinant of lysosomal targeting or extracellular secretion of alphaSYN and thereby contribute to the intercellular propagation of Lewy pathology in PD
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition.
Hanson et al., Saint Louis, United States. In J Biol Chem, 2010
Findings reveal new ways in which VPS4 activity is regulated and specifically directed to ESCRT-III polymers.
Seeds of Arabidopsis plants expressing dominant-negative AtSKD1 under control of the GL2 promoter show a transparent testa phenotype and a mucilage defect.
Schellmann et al., Köln, Germany. In Plant Signal Behav, 2010
Seeds of the dominant-negative AtSKD1 under control of GS2 promoter display a transparent testa phenotype caused by a lack of proanthocyanidin (PA) and do not possess seed coat mucilage.
Structure and function of ESCRT-III.
Weissenhorn et al., Grenoble, France. In Biochem Soc Trans, 2009
Progress towards the understanding of the structures and function of ESCRT-III, its activation, its regulation by accessory factors and its role in abscission of membrane enveloped structures in concert with VPS4 are discussed.
Maturation of autophagic vacuoles in Mammalian cells.
Eskelinen, Kiel, Germany. In Autophagy, 2005
The list of newly discovered molecules that regulate the maturation of autophagosomes to degradative autolysosomes includes the AAA ATPase SKD1, the small GTP binding protein Rab7, and possibly also the Alzheimer-linked presenilin 1.
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