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Vacuolar protein sorting 37 homolog C

VPS37C, hVps37C
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: TSG101, VPS28, HRs, ATPase, HCRP1
Papers on VPS37C
VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.
Maki et al., Nagoya, Japan. In Biosci Biotechnol Biochem, 2012
VPS37B and VPS37C appeared to interact with ALG-2 in a stronger manner than TSG101 does.
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Woodman et al., Manchester, United Kingdom. In Curr Biol, 2011
UBAP1 is part of a complex that contains a fraction of total cellular TSG101 and that also contains VPS37A but not VPS37C.
TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.
Tang et al., Beijing, China. In J Immunol, 2011
In this study, we demonstrated that TANK-binding kinase 1 (TBK1) directly interacted with VPS37C, a subunit of endosomal sorting complex required for transport-I (ESCRT-I) in the MVB pathway, without affecting the ultrastructure or general function of MVB.
Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations.
Bosch et al., Barcelona, Spain. In Mol Biol Evol, 2009
However, the signal of recent selection in this region may come from a different, neighboring gene (CD5) rather than from the candidate gene itself (VPS37C).
Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.
Bieniasz et al., New York City, United States. In J Biol Chem, 2005
VPS37C as a functional component of mammalian endosomal sorting complex required for transport-I
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation.
Stenmark et al., Oslo, Norway. In Mol Biol Cell, 2004
The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing proteins.
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