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Pre-B lymphocyte 1

VpreB, IGI, pre-B lymphocyte, VpreB1
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: lambda5, CAN, BCR, CD19, IgM
Papers on VpreB
LPS-Enhanced Glucose-Stimulated Insulin Secretion Is Normalized by Resveratrol.
Pedersen et al., Århus, Denmark. In Plos One, Dec 2015
LPS induced insulin resistance as the glucose-stimulated insulin secretion during an oral glucose tolerance test was increased despite similar plasma glucose level resulting in an increase in the insulinogenic index (IGI; delta0-15insulin / delta0-15glucose) from 13.73 to 22.40 pmol/mmol (P < 0.001).
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
Yaspo et al., Düsseldorf, Germany. In Nat Genet, Sep 2015
We identified recurrent intragenic deletions of PAX5 or VPREB1 in constellation with the fusion of TCF3 and HLF.
Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor, Improves Early-Phase Insulin Secretion in Drug-Naïve Patients with Type 2 Diabetes.
Hirano et al., Tokyo, Japan. In Drugs R D, Sep 2015
We investigated the changes in insulin secretion before and after treatment with the DPP-4 inhibitor teneligliptin in patients with T2D with a low insulinogenic index (IGI) determined by the oral glucose tolerance test (OGTT).
Semimechanistic model describing gastric emptying and glucose absorption in healthy subjects and patients with type 2 diabetes.
Kjellsson et al., Uppsala, Sweden. In J Clin Pharmacol, Aug 2015
UNASSIGNED: The integrated glucose-insulin (IGI) model is a previously published semimechanistic model that describes plasma glucose and insulin concentrations after glucose challenges.
Upgrading food wastes by means of bromelain and papain to enhance growth and immunity of grass carp (Ctenopharyngodon idella).
Wong et al., Hong Kong, Hong Kong. In Environ Sci Pollut Res Int, Jul 2015
The growth and immunity, reflected by total protein, total immunologlobulin (IgI), and nitroblue tetrazolium (NBT) activity of grass carp blood, were depressed when feeding with food waste feeds without enzymes.
Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.
Sasano et al., Sendai, Japan. In Endocr Pathol, May 2015
The pre-B lymphocyte protein 3 (VPREB3) is expressed during B cell differentiation and in subsets of mature B lymphocytes and is mainly found in bone marrow and lymphoid tissue germinative centers.
Transcriptional and metabolic pre-B cell receptor-mediated checkpoints: implications for autoimmune diseases.
Zouali, Paris, France. In Mol Immunol, 2014
At the pre-B cell stage of lymphocyte development, immunoglobulin light-chains are not yet produced, and heavy-chains are covalently linked to surrogate light-chains composed of VpreB and λ5 to form the pre-B cell receptor (pre-BCR) in a non-covalent association with signal-transducing modules.
Impaired B lymphopoiesis in old age: a role for inflammatory B cells?
Riley, Miami, United States. In Immunol Res, 2013
Both of these likely ensue from reduced expression of the surrogate light chain (λ5 + VpreB) and consequently reduced expression of the pre-B cell receptor (preBCR), critical to pre-B cell expansion and Vh selection.
Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?
Khan, El Paso, United States. In Front Neurosci, 2012
This approach can also be applied to those intracranial "gene-directed" injection (IGI) methods (e.g., site-specific recombinase methods, RNA expression or interference, optogenetics, and pharmacosynthetics) that involve viral injections to targeted neuronal populations.
The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.
Chung et al., Seoul, South Korea. In Mol Immunol, 2011
The proportion of the individuals with <2 copies of the VPREB1 gene was significantly higher in the patient group than that in the controls, while that of the individuals with >2 copies was lower in the patient group than that in the controls.
Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage.
Dillon et al., London, United Kingdom. In Cell Stem Cell, 2010
In ESCs, Sox2 contributes to the formation of a monovalent mark at an enhancer in the pro/pre-B cell-specific lambda5-VpreB1 locus.
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study.
Pieters et al., Rotterdam, Netherlands. In Lancet Oncol, 2009
36 (82%) of the patients with BCR-ABL1-like disease had deletions in genes involved in B-cell development, including IKZF1, TCF3, EBF1, PAX5, and VPREB1; only nine (36%) of 25 patients with B-other ALL had deletions in these genes (p=0.0002).
[(Biotin-Ala-Ser-Lys-Lys-Pro-Lys-Arg-Asn-Ile-Lys-Ala)4-dendrimer]-streptavidin-[biotin-gadolinium 1,4,7-tris(carboxymethyl)-10-(2’-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-loaded apoferritin]
Zhang, Bethesda, United States. In Unknown Journal, 2008
Evidence demonstrates that the homophilic interaction is mediated by a double reciprocal interaction between the IgI and IgII modules of two NCAM molecules (3).
Structural insight into pre-B cell receptor function.
Garcia et al., Stanford, United States. In Science, 2007
In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire.
Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.
Gauthier et al., Marseille, France. In J Immunol, 2006
Pre-B cell integrins and their stromal cell ligands together with the pre-B cell receptor and galectin-1 form a homogeneous lattice at the contact area between bone marrow pre-B and stromal cells.
The kappa-like pre-B receptor: surplus biology or a missing link?
Martinez-Valdez et al., Houston, United States. In Semin Immunol, 2006
The present review discusses the concept of the alternative usage of kappa-like pre-B cell receptors and classical pre-B cell receptors utilizing the lambda-like surrogate light chain composed of lambda5 and VpreB.
The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.
Sigvardsson et al., Lund, Sweden. In J Immunol, 2002
The 5' region of the VpreB gene contains a promoter which displays higher relative activity in preB cells compared with cells at other stages or from other lineages.
Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors.
Busslinger et al., Basel, Switzerland. In Nature, 1999
Moreover, the expression of genes encoding components of the rearrangement machinery (RAG1, RAG2, TdT) or pre-B-cell receptor (lambda5, VpreB, Igalpha, Igbeta) has been considered to indicate B-lineage commitment.
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